Development of Modified Release Nicotine Tablet Formulation for Treatment of Ulcerative Colitis

Development of Modified Release Nicotine Tablet Formulation for Treatment of Ulcerative Colitis

One of the therapeutic effects of nicotine  is used as  a protective against developing ulcerative colitis . ulcerative colitis is an inflammatory disease of the bowel affecting the superficial lining mucosa in the rectum and large intestine. In this study nicotine tablets were formulated as modifi...

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Main Author: Marwan Y. Al-hurr
Format: Article
Language:English
Published: College of Pharmacy University of Baghdad 2017-03-01
Series:Iraqi Journal of Pharmaceutical Sciences
Online Access:https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/511
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spelling doaj-8d2086b965d14bb3a99530882380da082021-06-20T10:10:41ZengCollege of Pharmacy University of BaghdadIraqi Journal of Pharmaceutical Sciences2521-35121683-35972017-03-0119210.31351/vol19iss2pp75-81Development of Modified Release Nicotine Tablet Formulation for Treatment of Ulcerative ColitisMarwan Y. Al-hurr One of the therapeutic effects of nicotine  is used as  a protective against developing ulcerative colitis . ulcerative colitis is an inflammatory disease of the bowel affecting the superficial lining mucosa in the rectum and large intestine. In this study nicotine tablets were formulated as modified release tablets targeted to the colon. All formulas were studied for drug release , effect of diluent, retardant concentration, avicel grade,and compression force, the selected formula was then further studied for drug release in 3 different pH ( coated tablets) .The kinetic study revealed acceptable shelf life  . Finally the selected formula was given to 6 patients in a pre-liminary clinical study which showed that nicotine can stabilize mild to moderate ulcerative colitis attacks. Key words: Ulcerative colitis, Nicotine, Modified release , Colon delivery. https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/511
collection DOAJ
language English
format Article
sources DOAJ
author Marwan Y. Al-hurr
spellingShingle Marwan Y. Al-hurr
Development of Modified Release Nicotine Tablet Formulation for Treatment of Ulcerative Colitis
Iraqi Journal of Pharmaceutical Sciences
author_facet Marwan Y. Al-hurr
author_sort Marwan Y. Al-hurr
title Development of Modified Release Nicotine Tablet Formulation for Treatment of Ulcerative Colitis
title_short Development of Modified Release Nicotine Tablet Formulation for Treatment of Ulcerative Colitis
title_full Development of Modified Release Nicotine Tablet Formulation for Treatment of Ulcerative Colitis
title_fullStr Development of Modified Release Nicotine Tablet Formulation for Treatment of Ulcerative Colitis
title_full_unstemmed Development of Modified Release Nicotine Tablet Formulation for Treatment of Ulcerative Colitis
title_sort development of modified release nicotine tablet formulation for treatment of ulcerative colitis
publisher College of Pharmacy University of Baghdad
series Iraqi Journal of Pharmaceutical Sciences
issn 2521-3512
1683-3597
publishDate 2017-03-01
description One of the therapeutic effects of nicotine  is used as  a protective against developing ulcerative colitis . ulcerative colitis is an inflammatory disease of the bowel affecting the superficial lining mucosa in the rectum and large intestine. In this study nicotine tablets were formulated as modified release tablets targeted to the colon. All formulas were studied for drug release , effect of diluent, retardant concentration, avicel grade,and compression force, the selected formula was then further studied for drug release in 3 different pH ( coated tablets) .The kinetic study revealed acceptable shelf life  . Finally the selected formula was given to 6 patients in a pre-liminary clinical study which showed that nicotine can stabilize mild to moderate ulcerative colitis attacks. Key words: Ulcerative colitis, Nicotine, Modified release , Colon delivery.
url https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/511
work_keys_str_mv AT marwanyalhurr developmentofmodifiedreleasenicotinetabletformulationfortreatmentofulcerativecolitis
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