Antidiarrheal, cytotoxic and thrombolytic activities of methanolic extract of Hedychium coccineum leaves

• Main Authors: Fahmida Shifah, Abu Montakim Tareq, Mohammed Aktar Sayeed, Mohammad Nazmul Islam, Talha Bin Emran, Md. Ahsan Ullah, Muhammad Abdul Mukit, Ahmed Ullah
• Format: Article
• Language: English
• Published: Bangladesh Society for Microbiology, Immunology, and Advanced Biotechnology 2020-04-01
• Series: Journal of Advanced Biotechnology and Experimental Therapeutics
• Subjects: hedychium coccineum; zingiberaceae; antidiarrheal; thrombolytic
• Online Access: http://www.ejmanager.com/fulltextpdf.php?mno=77330

The study reports the in vivo antidiarrheal and in vitro cytotoxic and thrombolytic activities of methanolic extract of Hedychium coccineum leaves (MEHCL). The antidiarrheal activity was evaluated by castor oil-induced diarrhea, whereas the intestinal motility by charcoal marker. In addition, brine shrimp lethality bioassay and human blood clot lysis were used to evaluate the cytotoxic and thrombolytic activities, respectively. In antidiarrheal study, castor oil-induced diarrhea and gastrointestinal motility exhibited a significant dose dependent reduction in diarrhea and defecation and an extremely significant (P < 0.0001) inhibition in intestinal motility and peristalsis index by 200 and 400 mg/kg of MEHCL. The brine shrimp lethality bioassay revealed a considerable cytotoxic effect of MEHCL (LC50= 81.59 µg/mL; R² = 0.927) while in thrombolytic a significant percentage of clot lysis (17.36%, P < 0.01) demonstrated. The findings suggest that H. coccineum leaves could be potential sources for biological activity. [ J Adv Biotechnol Exp Ther 2020; 3(1.000): 77-83]