Clinical analysis of cognitive function and depressive states in patients with age-related macular degeneration

• Main Authors: Na Li, Yun-Xia Xu, Xin Yan
• Format: Article
• Language: English
• Published: Press of International Journal of Ophthalmology (IJO PRESS) 2017-10-01
• Series: Guoji Yanke Zazhi
• Subjects: age-related macular degeneration; Mini-Mental State Examination; cognitive disorders; Geriatric Depression Scale; depression
• Online Access: http://ies.ijo.cn/cn_publish/2017/10/201710026.pdf

AIM: To investigate the difference of cognitive impairment and depression between age-related macular degeneration(AMD)group and the control group patients. <p>METHODS: A prospective case-control study was performed from November 2014 to August 2016 in the hospital for AMD patients and sex-matched control group. The Mini-Mental State Examination(MMSE)and the Geriatric Depression Scale(GDS)score of each patient were collected for statistical analyzing. <p>RESULTS: There were total 84 cases(168 eyes)included in the study. The difference of visual acuity between the two group was statistically significant(<i>F</i>=8.953, <i>P</i>=0.004)by baseline data analyzing. There were no significant differences in MMSE scores between the two groups according to educational status(<i>P</i>>0.05), while the prevalence of cognitive impairment in each group was statistically significant(<i>χ²</i>=4.14,<i> P</i>=0.042). The difference of GDS scores, prevalence of total and mild depression between two groups were both statistically significant(<i>F</i>=5.852, <i>P</i>=0.018; <i> χ</i>²=6.372, <i>P</i>=0.012; <i>χ</i>²=5.674, <i>P</i>=0.017). However, there was no statistically significant difference in the prevalence of moderate to severe depression(<i>χ</i>²=0.672, <i>P</i>=0.412). <p>CONCLUSION: AMD patients have a higher prevalence of depression. Although MMSE score differences were not statistically significant in subgroup analysis by educational levels, AMD patients are more likely to have cognitive impairment overall.