Recent Advances in Aptamer Discovery and Applications
Aptamers are short, single-stranded DNA, RNA, or synthetic XNA molecules that can be developed with high affinity and specificity to interact with any desired targets. They have been widely used in facilitating discoveries in basic research, ensuring food safety and monitoring the environment. Furth...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-03-01
|
Series: | Molecules |
Subjects: | |
Online Access: | http://www.mdpi.com/1420-3049/24/5/941 |
id |
doaj-8d29ffc8c8ac40348c841da085ea6603 |
---|---|
record_format |
Article |
spelling |
doaj-8d29ffc8c8ac40348c841da085ea66032020-11-25T01:20:23ZengMDPI AGMolecules1420-30492019-03-0124594110.3390/molecules24050941molecules24050941Recent Advances in Aptamer Discovery and ApplicationsYang Zhang0Bo Shiun Lai1Mario Juhas2College of Science, Harbin Institute of Technology, Shenzhen 518055, ChinaSchool of Medicine, Johns Hopkins University, Baltimore, MD 21205, USAInstitute of Medical Microbiology, University of Zurich, Gloriastrasse 28/30, CH-8006 Zurich, SwitzerlandAptamers are short, single-stranded DNA, RNA, or synthetic XNA molecules that can be developed with high affinity and specificity to interact with any desired targets. They have been widely used in facilitating discoveries in basic research, ensuring food safety and monitoring the environment. Furthermore, aptamers play promising roles as clinical diagnostics and therapeutic agents. This review provides update on the recent advances in this rapidly progressing field of research with particular emphasis on generation of aptamers and their applications in biosensing, biotechnology and medicine. The limitations and future directions of aptamers in target specific delivery and real-time detection are also discussed.http://www.mdpi.com/1420-3049/24/5/941aptamersystematic evolution of ligands by exponential enrichment (SELEX)diagnosticstherapeuticsbiosensornanorocket |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yang Zhang Bo Shiun Lai Mario Juhas |
spellingShingle |
Yang Zhang Bo Shiun Lai Mario Juhas Recent Advances in Aptamer Discovery and Applications Molecules aptamer systematic evolution of ligands by exponential enrichment (SELEX) diagnostics therapeutics biosensor nanorocket |
author_facet |
Yang Zhang Bo Shiun Lai Mario Juhas |
author_sort |
Yang Zhang |
title |
Recent Advances in Aptamer Discovery and Applications |
title_short |
Recent Advances in Aptamer Discovery and Applications |
title_full |
Recent Advances in Aptamer Discovery and Applications |
title_fullStr |
Recent Advances in Aptamer Discovery and Applications |
title_full_unstemmed |
Recent Advances in Aptamer Discovery and Applications |
title_sort |
recent advances in aptamer discovery and applications |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2019-03-01 |
description |
Aptamers are short, single-stranded DNA, RNA, or synthetic XNA molecules that can be developed with high affinity and specificity to interact with any desired targets. They have been widely used in facilitating discoveries in basic research, ensuring food safety and monitoring the environment. Furthermore, aptamers play promising roles as clinical diagnostics and therapeutic agents. This review provides update on the recent advances in this rapidly progressing field of research with particular emphasis on generation of aptamers and their applications in biosensing, biotechnology and medicine. The limitations and future directions of aptamers in target specific delivery and real-time detection are also discussed. |
topic |
aptamer systematic evolution of ligands by exponential enrichment (SELEX) diagnostics therapeutics biosensor nanorocket |
url |
http://www.mdpi.com/1420-3049/24/5/941 |
work_keys_str_mv |
AT yangzhang recentadvancesinaptamerdiscoveryandapplications AT boshiunlai recentadvancesinaptamerdiscoveryandapplications AT mariojuhas recentadvancesinaptamerdiscoveryandapplications |
_version_ |
1725134610635948032 |