Recent Advances in Aptamer Discovery and Applications

Aptamers are short, single-stranded DNA, RNA, or synthetic XNA molecules that can be developed with high affinity and specificity to interact with any desired targets. They have been widely used in facilitating discoveries in basic research, ensuring food safety and monitoring the environment. Furth...

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Main Authors:	Yang Zhang, Bo Shiun Lai, Mario Juhas
Format:	Article
Language:	English
Published:	MDPI AG 2019-03-01
Series:	Molecules
Subjects:	aptamer systematic evolution of ligands by exponential enrichment (SELEX) diagnostics therapeutics biosensor nanorocket
Online Access:	http://www.mdpi.com/1420-3049/24/5/941

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spelling	doaj-8d29ffc8c8ac40348c841da085ea66032020-11-25T01:20:23ZengMDPI AGMolecules1420-30492019-03-0124594110.3390/molecules24050941molecules24050941Recent Advances in Aptamer Discovery and ApplicationsYang Zhang0Bo Shiun Lai1Mario Juhas2College of Science, Harbin Institute of Technology, Shenzhen 518055, ChinaSchool of Medicine, Johns Hopkins University, Baltimore, MD 21205, USAInstitute of Medical Microbiology, University of Zurich, Gloriastrasse 28/30, CH-8006 Zurich, SwitzerlandAptamers are short, single-stranded DNA, RNA, or synthetic XNA molecules that can be developed with high affinity and specificity to interact with any desired targets. They have been widely used in facilitating discoveries in basic research, ensuring food safety and monitoring the environment. Furthermore, aptamers play promising roles as clinical diagnostics and therapeutic agents. This review provides update on the recent advances in this rapidly progressing field of research with particular emphasis on generation of aptamers and their applications in biosensing, biotechnology and medicine. The limitations and future directions of aptamers in target specific delivery and real-time detection are also discussed.http://www.mdpi.com/1420-3049/24/5/941aptamersystematic evolution of ligands by exponential enrichment (SELEX)diagnosticstherapeuticsbiosensornanorocket
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yang Zhang Bo Shiun Lai Mario Juhas
spellingShingle	Yang Zhang Bo Shiun Lai Mario Juhas Recent Advances in Aptamer Discovery and Applications Molecules aptamer systematic evolution of ligands by exponential enrichment (SELEX) diagnostics therapeutics biosensor nanorocket
author_facet	Yang Zhang Bo Shiun Lai Mario Juhas
author_sort	Yang Zhang
title	Recent Advances in Aptamer Discovery and Applications
title_short	Recent Advances in Aptamer Discovery and Applications
title_full	Recent Advances in Aptamer Discovery and Applications
title_fullStr	Recent Advances in Aptamer Discovery and Applications
title_full_unstemmed	Recent Advances in Aptamer Discovery and Applications
title_sort	recent advances in aptamer discovery and applications
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2019-03-01
description	Aptamers are short, single-stranded DNA, RNA, or synthetic XNA molecules that can be developed with high affinity and specificity to interact with any desired targets. They have been widely used in facilitating discoveries in basic research, ensuring food safety and monitoring the environment. Furthermore, aptamers play promising roles as clinical diagnostics and therapeutic agents. This review provides update on the recent advances in this rapidly progressing field of research with particular emphasis on generation of aptamers and their applications in biosensing, biotechnology and medicine. The limitations and future directions of aptamers in target specific delivery and real-time detection are also discussed.
topic	aptamer systematic evolution of ligands by exponential enrichment (SELEX) diagnostics therapeutics biosensor nanorocket
url	http://www.mdpi.com/1420-3049/24/5/941
work_keys_str_mv	AT yangzhang recentadvancesinaptamerdiscoveryandapplications AT boshiunlai recentadvancesinaptamerdiscoveryandapplications AT mariojuhas recentadvancesinaptamerdiscoveryandapplications
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Recent Advances in Aptamer Discovery and Applications

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