A direct projection from the subthalamic nucleus to the ventral thalamus in monkeys
The current basal ganglia model considers the internal division of the globus pallidus and the substantia nigra pars reticulata as the sole sources of basal ganglia output to the thalamus. However, following the delivery of retrograde tracers into the ventral anterior/ventral lateral thalamic nuclei...
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doaj-8d2c06d0cf564a1b9fdc03d9ffd0a18e2021-03-20T04:59:33ZengElsevierNeurobiology of Disease1095-953X2010-09-01393381392A direct projection from the subthalamic nucleus to the ventral thalamus in monkeysAlberto J. Rico0Pedro Barroso-Chinea1Lorena Conte-Perales2Elvira Roda3Virginia Gómez-Bautista4Miriam Gendive5José A. Obeso6José L. Lanciego7Area de Neurociencias, Centro de Investigación Médica Aplicada (CIMA), Facultad de Medicina, Universidad de Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Pamplona, SpainArea de Neurociencias, Centro de Investigación Médica Aplicada (CIMA), Facultad de Medicina, Universidad de Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Pamplona, SpainArea de Neurociencias, Centro de Investigación Médica Aplicada (CIMA), Facultad de Medicina, Universidad de Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Pamplona, SpainArea de Neurociencias, Centro de Investigación Médica Aplicada (CIMA), Facultad de Medicina, Universidad de Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Pamplona, SpainArea de Neurociencias, Centro de Investigación Médica Aplicada (CIMA), Facultad de Medicina, Universidad de Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Pamplona, SpainArea de Neurociencias, Centro de Investigación Médica Aplicada (CIMA), Facultad de Medicina, Universidad de Navarra, Pamplona, SpainArea de Neurociencias, Centro de Investigación Médica Aplicada (CIMA), Facultad de Medicina, Universidad de Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Pamplona, SpainArea de Neurociencias, Centro de Investigación Médica Aplicada (CIMA), Facultad de Medicina, Universidad de Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Pamplona, Spain; Corresponding author. Area de Neurociencias, Centro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Pio XII Ave. 55, 31008 Pamplona, Spain. Fax: +34 948 194 715.The current basal ganglia model considers the internal division of the globus pallidus and the substantia nigra pars reticulata as the sole sources of basal ganglia output to the thalamus. However, following the delivery of retrograde tracers into the ventral anterior/ventral lateral thalamic nuclei, a moderate number of labeled neurons were found within the subthalamic nucleus (STN) in control cases, MPTP-treated monkeys and animals with levodopa-induced dyskinesias. Furthermore, dual tracing experiments showed that subthalamo-thalamic and subthalamo-pallidal projections arise from different subpopulations of STN efferent neurons. Moreover, upregulated expression of the mRNA coding the vesicular glutamate transporter 2 (vGlut2) was found in retrogradely-labeled STN neurons in MPTP-treated monkeys. By contrast, there is a reduction in vGlut2 mRNA expression in subthalamo-thalamic neurons in dyskinetic monkeys. In conclusion, our findings support the presence of a direct projection from the STN to the ventral thalamus that appears to be functionally modulated by dopaminergic activity.http://www.sciencedirect.com/science/article/pii/S0969996110001555Basal gangliaMPTPHyperdirect pathwayRetrograde tracingParkinson's disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alberto J. Rico Pedro Barroso-Chinea Lorena Conte-Perales Elvira Roda Virginia Gómez-Bautista Miriam Gendive José A. Obeso José L. Lanciego |
spellingShingle |
Alberto J. Rico Pedro Barroso-Chinea Lorena Conte-Perales Elvira Roda Virginia Gómez-Bautista Miriam Gendive José A. Obeso José L. Lanciego A direct projection from the subthalamic nucleus to the ventral thalamus in monkeys Neurobiology of Disease Basal ganglia MPTP Hyperdirect pathway Retrograde tracing Parkinson's disease |
author_facet |
Alberto J. Rico Pedro Barroso-Chinea Lorena Conte-Perales Elvira Roda Virginia Gómez-Bautista Miriam Gendive José A. Obeso José L. Lanciego |
author_sort |
Alberto J. Rico |
title |
A direct projection from the subthalamic nucleus to the ventral thalamus in monkeys |
title_short |
A direct projection from the subthalamic nucleus to the ventral thalamus in monkeys |
title_full |
A direct projection from the subthalamic nucleus to the ventral thalamus in monkeys |
title_fullStr |
A direct projection from the subthalamic nucleus to the ventral thalamus in monkeys |
title_full_unstemmed |
A direct projection from the subthalamic nucleus to the ventral thalamus in monkeys |
title_sort |
direct projection from the subthalamic nucleus to the ventral thalamus in monkeys |
publisher |
Elsevier |
series |
Neurobiology of Disease |
issn |
1095-953X |
publishDate |
2010-09-01 |
description |
The current basal ganglia model considers the internal division of the globus pallidus and the substantia nigra pars reticulata as the sole sources of basal ganglia output to the thalamus. However, following the delivery of retrograde tracers into the ventral anterior/ventral lateral thalamic nuclei, a moderate number of labeled neurons were found within the subthalamic nucleus (STN) in control cases, MPTP-treated monkeys and animals with levodopa-induced dyskinesias. Furthermore, dual tracing experiments showed that subthalamo-thalamic and subthalamo-pallidal projections arise from different subpopulations of STN efferent neurons. Moreover, upregulated expression of the mRNA coding the vesicular glutamate transporter 2 (vGlut2) was found in retrogradely-labeled STN neurons in MPTP-treated monkeys. By contrast, there is a reduction in vGlut2 mRNA expression in subthalamo-thalamic neurons in dyskinetic monkeys. In conclusion, our findings support the presence of a direct projection from the STN to the ventral thalamus that appears to be functionally modulated by dopaminergic activity. |
topic |
Basal ganglia MPTP Hyperdirect pathway Retrograde tracing Parkinson's disease |
url |
http://www.sciencedirect.com/science/article/pii/S0969996110001555 |
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