A direct projection from the subthalamic nucleus to the ventral thalamus in monkeys

The current basal ganglia model considers the internal division of the globus pallidus and the substantia nigra pars reticulata as the sole sources of basal ganglia output to the thalamus. However, following the delivery of retrograde tracers into the ventral anterior/ventral lateral thalamic nuclei...

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Main Authors: Alberto J. Rico, Pedro Barroso-Chinea, Lorena Conte-Perales, Elvira Roda, Virginia Gómez-Bautista, Miriam Gendive, José A. Obeso, José L. Lanciego
Format: Article
Language:English
Published: Elsevier 2010-09-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110001555
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spelling doaj-8d2c06d0cf564a1b9fdc03d9ffd0a18e2021-03-20T04:59:33ZengElsevierNeurobiology of Disease1095-953X2010-09-01393381392A direct projection from the subthalamic nucleus to the ventral thalamus in monkeysAlberto J. Rico0Pedro Barroso-Chinea1Lorena Conte-Perales2Elvira Roda3Virginia Gómez-Bautista4Miriam Gendive5José A. Obeso6José L. Lanciego7Area de Neurociencias, Centro de Investigación Médica Aplicada (CIMA), Facultad de Medicina, Universidad de Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Pamplona, SpainArea de Neurociencias, Centro de Investigación Médica Aplicada (CIMA), Facultad de Medicina, Universidad de Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Pamplona, SpainArea de Neurociencias, Centro de Investigación Médica Aplicada (CIMA), Facultad de Medicina, Universidad de Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Pamplona, SpainArea de Neurociencias, Centro de Investigación Médica Aplicada (CIMA), Facultad de Medicina, Universidad de Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Pamplona, SpainArea de Neurociencias, Centro de Investigación Médica Aplicada (CIMA), Facultad de Medicina, Universidad de Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Pamplona, SpainArea de Neurociencias, Centro de Investigación Médica Aplicada (CIMA), Facultad de Medicina, Universidad de Navarra, Pamplona, SpainArea de Neurociencias, Centro de Investigación Médica Aplicada (CIMA), Facultad de Medicina, Universidad de Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Pamplona, SpainArea de Neurociencias, Centro de Investigación Médica Aplicada (CIMA), Facultad de Medicina, Universidad de Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Pamplona, Spain; Corresponding author. Area de Neurociencias, Centro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Pio XII Ave. 55, 31008 Pamplona, Spain. Fax: +34 948 194 715.The current basal ganglia model considers the internal division of the globus pallidus and the substantia nigra pars reticulata as the sole sources of basal ganglia output to the thalamus. However, following the delivery of retrograde tracers into the ventral anterior/ventral lateral thalamic nuclei, a moderate number of labeled neurons were found within the subthalamic nucleus (STN) in control cases, MPTP-treated monkeys and animals with levodopa-induced dyskinesias. Furthermore, dual tracing experiments showed that subthalamo-thalamic and subthalamo-pallidal projections arise from different subpopulations of STN efferent neurons. Moreover, upregulated expression of the mRNA coding the vesicular glutamate transporter 2 (vGlut2) was found in retrogradely-labeled STN neurons in MPTP-treated monkeys. By contrast, there is a reduction in vGlut2 mRNA expression in subthalamo-thalamic neurons in dyskinetic monkeys. In conclusion, our findings support the presence of a direct projection from the STN to the ventral thalamus that appears to be functionally modulated by dopaminergic activity.http://www.sciencedirect.com/science/article/pii/S0969996110001555Basal gangliaMPTPHyperdirect pathwayRetrograde tracingParkinson's disease
collection DOAJ
language English
format Article
sources DOAJ
author Alberto J. Rico
Pedro Barroso-Chinea
Lorena Conte-Perales
Elvira Roda
Virginia Gómez-Bautista
Miriam Gendive
José A. Obeso
José L. Lanciego
spellingShingle Alberto J. Rico
Pedro Barroso-Chinea
Lorena Conte-Perales
Elvira Roda
Virginia Gómez-Bautista
Miriam Gendive
José A. Obeso
José L. Lanciego
A direct projection from the subthalamic nucleus to the ventral thalamus in monkeys
Neurobiology of Disease
Basal ganglia
MPTP
Hyperdirect pathway
Retrograde tracing
Parkinson's disease
author_facet Alberto J. Rico
Pedro Barroso-Chinea
Lorena Conte-Perales
Elvira Roda
Virginia Gómez-Bautista
Miriam Gendive
José A. Obeso
José L. Lanciego
author_sort Alberto J. Rico
title A direct projection from the subthalamic nucleus to the ventral thalamus in monkeys
title_short A direct projection from the subthalamic nucleus to the ventral thalamus in monkeys
title_full A direct projection from the subthalamic nucleus to the ventral thalamus in monkeys
title_fullStr A direct projection from the subthalamic nucleus to the ventral thalamus in monkeys
title_full_unstemmed A direct projection from the subthalamic nucleus to the ventral thalamus in monkeys
title_sort direct projection from the subthalamic nucleus to the ventral thalamus in monkeys
publisher Elsevier
series Neurobiology of Disease
issn 1095-953X
publishDate 2010-09-01
description The current basal ganglia model considers the internal division of the globus pallidus and the substantia nigra pars reticulata as the sole sources of basal ganglia output to the thalamus. However, following the delivery of retrograde tracers into the ventral anterior/ventral lateral thalamic nuclei, a moderate number of labeled neurons were found within the subthalamic nucleus (STN) in control cases, MPTP-treated monkeys and animals with levodopa-induced dyskinesias. Furthermore, dual tracing experiments showed that subthalamo-thalamic and subthalamo-pallidal projections arise from different subpopulations of STN efferent neurons. Moreover, upregulated expression of the mRNA coding the vesicular glutamate transporter 2 (vGlut2) was found in retrogradely-labeled STN neurons in MPTP-treated monkeys. By contrast, there is a reduction in vGlut2 mRNA expression in subthalamo-thalamic neurons in dyskinetic monkeys. In conclusion, our findings support the presence of a direct projection from the STN to the ventral thalamus that appears to be functionally modulated by dopaminergic activity.
topic Basal ganglia
MPTP
Hyperdirect pathway
Retrograde tracing
Parkinson's disease
url http://www.sciencedirect.com/science/article/pii/S0969996110001555
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