Probable levetiracetam-related serum alkaline phosphatase elevation

• Main Authors: Xiong Nian, Hou Lingling, Lu Na, Mohamed Asrah A, Wang Tao, Huang Yaling
• Format: Article
• Language: English
• Published: BMC 2012-09-01
• Series: BMC Neurology
• Subjects: Levetiracetam; Serum alkaline phosphatase; Hepatotoxicity; Antiepileptic drugs; Epilepsy
• Online Access: http://www.biomedcentral.com/1471-2377/12/97

<p>Abstract</p> <p>Background</p> <p>Levetiracetam (LEV) is an antiepileptic drug with a favorable tolerability and safety profile with little or no effect on liver function.</p> <p>Case presentation</p> <p>Here, we reported an epileptic pediatric patient who developed a significant elevation in serum alkaline phosphatase level (ALP) during LEV monotherapy. Moreover, the serum ALP level was surprisingly decreased to normal after LEV discontinuation. The Naranjo Adverse Drug Reaction Probability Scale score was 6, indicating firstly LEV was a probable cause for the increased serum ALP.</p> <p>Conclusions</p> <p>Cautious usage and concerns of the LEV-associated potential ALP elevation should be considered when levetiracetam is prescribed to epilepsy patients, especially pediatric patients.</p>