Phylointeractomics reconstructs functional evolution of protein binding

Since protein interactions can be sensitive to small sequence changes, phylogenomics alone gives limited insight into protein functional evolution. Here, the authors illustrate how the combination of phylogenomics and interaction proteomics helps elucidate protein functional evolution with a study o...

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Main Authors:	Dennis Kappei, Marion Scheibe, Maciej Paszkowski-Rogacz, Alina Bluhm, Toni Ingolf Gossmann, Sabrina Dietz, Mario Dejung, Holger Herlyn, Frank Buchholz, Matthias Mann, Falk Butter
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms14334

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spelling	doaj-8d2c6013e78f4544b5d7c1228b6c73572021-05-11T07:47:53ZengNature Publishing GroupNature Communications2041-17232017-02-01811910.1038/ncomms14334Phylointeractomics reconstructs functional evolution of protein bindingDennis Kappei0Marion Scheibe1Maciej Paszkowski-Rogacz2Alina Bluhm3Toni Ingolf Gossmann4Sabrina Dietz5Mario Dejung6Holger Herlyn7Frank Buchholz8Matthias Mann9Falk Butter10Cancer Science Institute of Singapore, National University of SingaporeInstitute of Molecular Biology (IMB) gGmbHMedical Systems Biology, UCC, University Hospital and Medical Faculty Carl Gustav Carus, TU DresdenInstitute of Molecular Biology (IMB) gGmbHDepartment of Animal & Plant Sciences, University of Sheffield, Western Bank, Sheffield S10 2TN, UKInstitute of Molecular Biology (IMB) gGmbHInstitute of Molecular Biology (IMB) gGmbHInstitute of Anthropology, University of MainzMedical Systems Biology, UCC, University Hospital and Medical Faculty Carl Gustav Carus, TU DresdenDepartment of Proteomics and Signal Transduction, Max Planck Institute of BiochemistryInstitute of Molecular Biology (IMB) gGmbHSince protein interactions can be sensitive to small sequence changes, phylogenomics alone gives limited insight into protein functional evolution. Here, the authors illustrate how the combination of phylogenomics and interaction proteomics helps elucidate protein functional evolution with a study of the shelterin complex evolution.https://doi.org/10.1038/ncomms14334
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Dennis Kappei Marion Scheibe Maciej Paszkowski-Rogacz Alina Bluhm Toni Ingolf Gossmann Sabrina Dietz Mario Dejung Holger Herlyn Frank Buchholz Matthias Mann Falk Butter
spellingShingle	Dennis Kappei Marion Scheibe Maciej Paszkowski-Rogacz Alina Bluhm Toni Ingolf Gossmann Sabrina Dietz Mario Dejung Holger Herlyn Frank Buchholz Matthias Mann Falk Butter Phylointeractomics reconstructs functional evolution of protein binding Nature Communications
author_facet	Dennis Kappei Marion Scheibe Maciej Paszkowski-Rogacz Alina Bluhm Toni Ingolf Gossmann Sabrina Dietz Mario Dejung Holger Herlyn Frank Buchholz Matthias Mann Falk Butter
author_sort	Dennis Kappei
title	Phylointeractomics reconstructs functional evolution of protein binding
title_short	Phylointeractomics reconstructs functional evolution of protein binding
title_full	Phylointeractomics reconstructs functional evolution of protein binding
title_fullStr	Phylointeractomics reconstructs functional evolution of protein binding
title_full_unstemmed	Phylointeractomics reconstructs functional evolution of protein binding
title_sort	phylointeractomics reconstructs functional evolution of protein binding
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-02-01
description	Since protein interactions can be sensitive to small sequence changes, phylogenomics alone gives limited insight into protein functional evolution. Here, the authors illustrate how the combination of phylogenomics and interaction proteomics helps elucidate protein functional evolution with a study of the shelterin complex evolution.
url	https://doi.org/10.1038/ncomms14334
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Phylointeractomics reconstructs functional evolution of protein binding

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