Perturbed Wnt signaling leads to neuronal migration delay, altered interhemispheric connections and impaired social behavior

Functional consequence of transient delay in neuronal migration is unclear. This study shows that Wnt/C-Kit signaling regulates radial migration in rat somatosensory cortex, and that transient delay of L2/3 neuronal migration leads to interhemispheric connectivity alteration and abnormal social beha...

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Main Authors:	Riccardo Bocchi, Kristof Egervari, Laura Carol-Perdiguer, Beatrice Viale, Charles Quairiaux, Mathias De Roo, Michael Boitard, Suzanne Oskouie, Patrick Salmon, Jozsef Z. Kiss
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-01046-w

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spelling	doaj-8d2f9638ad8e4f4bba3636fccca2602d2021-05-11T07:22:46ZengNature Publishing GroupNature Communications2041-17232017-10-018111510.1038/s41467-017-01046-wPerturbed Wnt signaling leads to neuronal migration delay, altered interhemispheric connections and impaired social behaviorRiccardo Bocchi0Kristof Egervari1Laura Carol-Perdiguer2Beatrice Viale3Charles Quairiaux4Mathias De Roo5Michael Boitard6Suzanne Oskouie7Patrick Salmon8Jozsef Z. Kiss9Department of Basic Neurosciences, University of Geneva Medical SchoolDepartment of Basic Neurosciences, University of Geneva Medical SchoolDepartment of Basic Neurosciences, University of Geneva Medical SchoolDepartment of Basic Neurosciences, University of Geneva Medical SchoolDepartment of Basic Neurosciences, University of Geneva Medical SchoolDepartment of Basic Neurosciences, University of Geneva Medical SchoolDepartment of Basic Neurosciences, University of Geneva Medical SchoolDepartment of Basic Neurosciences, University of Geneva Medical SchoolDepartment of Basic Neurosciences, University of Geneva Medical SchoolDepartment of Basic Neurosciences, University of Geneva Medical SchoolFunctional consequence of transient delay in neuronal migration is unclear. This study shows that Wnt/C-Kit signaling regulates radial migration in rat somatosensory cortex, and that transient delay of L2/3 neuronal migration leads to interhemispheric connectivity alteration and abnormal social behavior.https://doi.org/10.1038/s41467-017-01046-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Riccardo Bocchi Kristof Egervari Laura Carol-Perdiguer Beatrice Viale Charles Quairiaux Mathias De Roo Michael Boitard Suzanne Oskouie Patrick Salmon Jozsef Z. Kiss
spellingShingle	Riccardo Bocchi Kristof Egervari Laura Carol-Perdiguer Beatrice Viale Charles Quairiaux Mathias De Roo Michael Boitard Suzanne Oskouie Patrick Salmon Jozsef Z. Kiss Perturbed Wnt signaling leads to neuronal migration delay, altered interhemispheric connections and impaired social behavior Nature Communications
author_facet	Riccardo Bocchi Kristof Egervari Laura Carol-Perdiguer Beatrice Viale Charles Quairiaux Mathias De Roo Michael Boitard Suzanne Oskouie Patrick Salmon Jozsef Z. Kiss
author_sort	Riccardo Bocchi
title	Perturbed Wnt signaling leads to neuronal migration delay, altered interhemispheric connections and impaired social behavior
title_short	Perturbed Wnt signaling leads to neuronal migration delay, altered interhemispheric connections and impaired social behavior
title_full	Perturbed Wnt signaling leads to neuronal migration delay, altered interhemispheric connections and impaired social behavior
title_fullStr	Perturbed Wnt signaling leads to neuronal migration delay, altered interhemispheric connections and impaired social behavior
title_full_unstemmed	Perturbed Wnt signaling leads to neuronal migration delay, altered interhemispheric connections and impaired social behavior
title_sort	perturbed wnt signaling leads to neuronal migration delay, altered interhemispheric connections and impaired social behavior
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-10-01
description	Functional consequence of transient delay in neuronal migration is unclear. This study shows that Wnt/C-Kit signaling regulates radial migration in rat somatosensory cortex, and that transient delay of L2/3 neuronal migration leads to interhemispheric connectivity alteration and abnormal social behavior.
url	https://doi.org/10.1038/s41467-017-01046-w
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Perturbed Wnt signaling leads to neuronal migration delay, altered interhemispheric connections and impaired social behavior

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