Chlorocarbonylsulfenyl chloride cyclizations towards piperidin-3-yl-oxathiazol-2-ones as potential covalent inhibitors of threonine proteases

Chlorocarbonylsulfenyl chloride cyclizations towards piperidin-3-yl-oxathiazol-2-ones as potential covalent inhibitors of threonine proteases

Using rescaffolding approach, we designed piperidine compounds decorated with an electrophilic oxathiazol-2-one moiety that is known to confer selectivity towards threonine proteases. Our efforts to prepare products according to the published procedures were not successful. Furthermore we identified...

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Bibliographic Details
Main Authors: Ales Obreza, Katarina Grabrijan, Selmir Kadić, Fernando Juan de Lera Garrido, Izidor Sosič, Stanislav Gobec, Marko Jukič
Format: Article
Language:English
Published: Slovenian Chemical Society 2017-12-01
Series:Acta Chimica Slovenica
Subjects:
cyclization
amide dehydration
oxathiazole-2-one
threonine protease
covalent inhibitors
irreversible inhibition
Online Access:https://journals.matheo.si/index.php/ACSi/article/view/3883

Internet

https://journals.matheo.si/index.php/ACSi/article/view/3883

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