Immunological deficiencies: more frequent than they seem to be
Objective: A review article was carried out, addressing the clinical and epidemiological characteristics of immune system deficiencies, which are associated with or predispose to recurrent infectious processes, autoimmune diseases, auto inflammatory diseases, or neoplasms, and which are classified a...
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2021-03-01
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doaj-8d3fb1d059d7464e9786e393114a05b72021-03-19T07:01:40ZengElsevierJornal de Pediatria0021-75572021-03-0197S49S58Immunological deficiencies: more frequent than they seem to beIrma Cecília Douglas Paes Barreto0Bruno Acatauassú Paes Barreto1Erica Gomes do Nascimento Cavalcante2Antonio Condino Neto3Centro Universitário do Estado do Pará (CESUPA), Departamento de Pediatria, Serviço de Alergia e Imunologia Pediátrica, Belém, PA, Brazil; Corresponding author.Centro Universitário do Estado do Pará (CESUPA), Departamento de Pediatria, Serviço de Alergia e Imunologia Pediátrica, Belém, PA, Brazil; Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, BrazilUniversidade de São Paulo (USP), São Paulo, SP, Brazil; Centro Universitário do Estado do Pará (CESUPA), Departamento de Pediatria, Serviço de Reumatologia Pediátrica, Belém, PA, BrazilUniversidade de São Paulo (USP), Instituto de Ciências Biomédicas, Departamento de Imunologia, São Paulo, SP, BrazilObjective: A review article was carried out, addressing the clinical and epidemiological characteristics of immune system deficiencies, which are associated with or predispose to recurrent infectious processes, autoimmune diseases, auto inflammatory diseases, or neoplasms, and which are classified as inborn errors of immunity (IEI) and secondary immunodeficiencies (SID). Emphasis was placed on the classification of the main signs and symptoms for each organ and system, which will serve as warning signs, to guide the pediatrician in the investigation of the main IEI. In addition, the main secondary changes in the immune system triggered by infections (with emphasis on COVID-19), drugs, chronic diseases, metabolic and nutritional disorders were identified. Sources of data: This review included articles published in the last five years and that were identified in the MEDLINE platform (PubMed). Summary of findings: The recurrence of infectious processes, associated with the severity of the condition and/or unusual profile of the infectious agent, always related to the age range of symptom onset, are the most important findings for suspected diagnosis. Conclusions: Considering this scenario, immunity disorders should be part of the investigation carried out by the general pediatrician, whether they are the innate errors of immunity (primary immunodeficiencies) or secondary immunodeficiencies, so that the diagnosis is attained as early as possible and therapeutic measures are implemented, reducing the morbidity and mortality of these patients.http://www.sciencedirect.com/science/article/pii/S0021755720302266Primary immunodeficiency disordersImmunodeficiency disordersClassificationEpidemiologyCOVID-19SARS-CoV-2 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Irma Cecília Douglas Paes Barreto Bruno Acatauassú Paes Barreto Erica Gomes do Nascimento Cavalcante Antonio Condino Neto |
spellingShingle |
Irma Cecília Douglas Paes Barreto Bruno Acatauassú Paes Barreto Erica Gomes do Nascimento Cavalcante Antonio Condino Neto Immunological deficiencies: more frequent than they seem to be Jornal de Pediatria Primary immunodeficiency disorders Immunodeficiency disorders Classification Epidemiology COVID-19 SARS-CoV-2 |
author_facet |
Irma Cecília Douglas Paes Barreto Bruno Acatauassú Paes Barreto Erica Gomes do Nascimento Cavalcante Antonio Condino Neto |
author_sort |
Irma Cecília Douglas Paes Barreto |
title |
Immunological deficiencies: more frequent than they seem to be |
title_short |
Immunological deficiencies: more frequent than they seem to be |
title_full |
Immunological deficiencies: more frequent than they seem to be |
title_fullStr |
Immunological deficiencies: more frequent than they seem to be |
title_full_unstemmed |
Immunological deficiencies: more frequent than they seem to be |
title_sort |
immunological deficiencies: more frequent than they seem to be |
publisher |
Elsevier |
series |
Jornal de Pediatria |
issn |
0021-7557 |
publishDate |
2021-03-01 |
description |
Objective: A review article was carried out, addressing the clinical and epidemiological characteristics of immune system deficiencies, which are associated with or predispose to recurrent infectious processes, autoimmune diseases, auto inflammatory diseases, or neoplasms, and which are classified as inborn errors of immunity (IEI) and secondary immunodeficiencies (SID). Emphasis was placed on the classification of the main signs and symptoms for each organ and system, which will serve as warning signs, to guide the pediatrician in the investigation of the main IEI. In addition, the main secondary changes in the immune system triggered by infections (with emphasis on COVID-19), drugs, chronic diseases, metabolic and nutritional disorders were identified. Sources of data: This review included articles published in the last five years and that were identified in the MEDLINE platform (PubMed). Summary of findings: The recurrence of infectious processes, associated with the severity of the condition and/or unusual profile of the infectious agent, always related to the age range of symptom onset, are the most important findings for suspected diagnosis. Conclusions: Considering this scenario, immunity disorders should be part of the investigation carried out by the general pediatrician, whether they are the innate errors of immunity (primary immunodeficiencies) or secondary immunodeficiencies, so that the diagnosis is attained as early as possible and therapeutic measures are implemented, reducing the morbidity and mortality of these patients. |
topic |
Primary immunodeficiency disorders Immunodeficiency disorders Classification Epidemiology COVID-19 SARS-CoV-2 |
url |
http://www.sciencedirect.com/science/article/pii/S0021755720302266 |
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