A synthetic ion channel with anisotropic ligand response
Transmembrane proteins are important for cellular functions and synthetic analogues are of interest. Here the authors report on the design and testing of a synthetic multipass transmembrane channel which shows anisotropic responses to agonistic and antagonistic ligands.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16770-z |
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doaj-8d4b05d38a764d63897b3b2f6cc88bf52021-06-13T11:18:15ZengNature Publishing GroupNature Communications2041-17232020-06-011111910.1038/s41467-020-16770-zA synthetic ion channel with anisotropic ligand responseTakahiro Muraoka0Daiki Noguchi1Rinshi S. Kasai2Kohei Sato3Ryo Sasaki4Kazuhito V. Tabata5Toru Ekimoto6Mitsunori Ikeguchi7Kiyoto Kamagata8Norihisa Hoshino9Hiroyuki Noji10Tomoyuki Akutagawa11Kazuaki Ichimura12Kazushi Kinbara13School of Life Science and Technology, Tokyo Institute of TechnologyInstitute of Multidisciplinary Research for Advanced Materials, Tohoku UniversityInstitute for Frontier Life and Medical Sciences, Kyoto University, ShougoinSchool of Life Science and Technology, Tokyo Institute of TechnologySchool of Life Science and Technology, Tokyo Institute of TechnologyDepartment of Applied Chemistry, School of Engineering, The University of Tokyo, Bunkyo-kuGraduate School of Medical Life Science, Yokohama City UniversityGraduate School of Medical Life Science, Yokohama City UniversityInstitute of Multidisciplinary Research for Advanced Materials, Tohoku UniversityInstitute of Multidisciplinary Research for Advanced Materials, Tohoku UniversityDepartment of Applied Chemistry, School of Engineering, The University of Tokyo, Bunkyo-kuInstitute of Multidisciplinary Research for Advanced Materials, Tohoku UniversitySchool of Life Science and Technology, Tokyo Institute of TechnologySchool of Life Science and Technology, Tokyo Institute of TechnologyTransmembrane proteins are important for cellular functions and synthetic analogues are of interest. Here the authors report on the design and testing of a synthetic multipass transmembrane channel which shows anisotropic responses to agonistic and antagonistic ligands.https://doi.org/10.1038/s41467-020-16770-z |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Takahiro Muraoka Daiki Noguchi Rinshi S. Kasai Kohei Sato Ryo Sasaki Kazuhito V. Tabata Toru Ekimoto Mitsunori Ikeguchi Kiyoto Kamagata Norihisa Hoshino Hiroyuki Noji Tomoyuki Akutagawa Kazuaki Ichimura Kazushi Kinbara |
| spellingShingle |
Takahiro Muraoka Daiki Noguchi Rinshi S. Kasai Kohei Sato Ryo Sasaki Kazuhito V. Tabata Toru Ekimoto Mitsunori Ikeguchi Kiyoto Kamagata Norihisa Hoshino Hiroyuki Noji Tomoyuki Akutagawa Kazuaki Ichimura Kazushi Kinbara A synthetic ion channel with anisotropic ligand response Nature Communications |
| author_facet |
Takahiro Muraoka Daiki Noguchi Rinshi S. Kasai Kohei Sato Ryo Sasaki Kazuhito V. Tabata Toru Ekimoto Mitsunori Ikeguchi Kiyoto Kamagata Norihisa Hoshino Hiroyuki Noji Tomoyuki Akutagawa Kazuaki Ichimura Kazushi Kinbara |
| author_sort |
Takahiro Muraoka |
| title |
A synthetic ion channel with anisotropic ligand response |
| title_short |
A synthetic ion channel with anisotropic ligand response |
| title_full |
A synthetic ion channel with anisotropic ligand response |
| title_fullStr |
A synthetic ion channel with anisotropic ligand response |
| title_full_unstemmed |
A synthetic ion channel with anisotropic ligand response |
| title_sort |
synthetic ion channel with anisotropic ligand response |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-06-01 |
| description |
Transmembrane proteins are important for cellular functions and synthetic analogues are of interest. Here the authors report on the design and testing of a synthetic multipass transmembrane channel which shows anisotropic responses to agonistic and antagonistic ligands. |
| url |
https://doi.org/10.1038/s41467-020-16770-z |
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