Association of the rs555172 polymorphism in SENCR long non-coding RNA and atherosclerotic coronary artery disease
Introduction: Variants in long non-coding RNAs (lncRNAs) have been implicated as potential biomarkers in prediction of complex disorders such as coronary artery disease (CAD). Studies considering the impact of the SENCR antisense lncRNAs on CAD have not established yet in Iranian population. This st...
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doaj-8d4e671ab5b44b7d88c57070688d09a02020-11-24T21:47:59ZengTabriz University of Medical SciencesJournal of Cardiovascular and Thoracic Research2008-51172008-68302017-09-019317017410.15171/jcvtr.2017.29JCVTR_19269_20170404022543Association of the rs555172 polymorphism in SENCR long non-coding RNA and atherosclerotic coronary artery diseaseNahid Shahmoradi0Mahboobeh Nasiri1Hajar Kamfiroozi2Mohammad Ali Kheiry3Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, IranDepartment of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, IranDepartment of Cardiology, Shiraz University of Medical Sciences, Shiraz, IranInternist-Cardiologist, Private Dr. Kheiry Clinic, Neyriz, Fars, IranIntroduction: Variants in long non-coding RNAs (lncRNAs) have been implicated as potential biomarkers in prediction of complex disorders such as coronary artery disease (CAD). Studies considering the impact of the SENCR antisense lncRNAs on CAD have not established yet in Iranian population. This study aimed to investigate the association between SENCR rs555172 polymorphism and CAD in south Iranian population. Methods: Amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) was performed to determine the allele and the genotype distribution of SENCR lncRNA polymorphism in 150 patients with CAD compared with 149 healthy controls through this hospital-based case-control study. Results: The frequency of AA, AG, and GG genotypes in cases were 32.7%, 44.7%, and 22.6%, and in controls were 26.8%, 49%, and 24.2%, respectively. Association was not found with any of the genotypes in comparison of cases and controls. The allelic frequencies did not differ between cases and controls. Cross-tabulating the population based on the gender, the frequency of the GG genotype was significantly higher among women of the case group compared to men. The difference was not seen in the control group between two sexes. Conclusion: The results suggested that the SENCR gene polymorphism did not confer susceptibility to CAD.http://jcvtr.tbzmed.ac.ir/PDF/JCVTR-9-170.pdfCoronary Artery DiseasePolymorphismSENCRlncRNA |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nahid Shahmoradi Mahboobeh Nasiri Hajar Kamfiroozi Mohammad Ali Kheiry |
spellingShingle |
Nahid Shahmoradi Mahboobeh Nasiri Hajar Kamfiroozi Mohammad Ali Kheiry Association of the rs555172 polymorphism in SENCR long non-coding RNA and atherosclerotic coronary artery disease Journal of Cardiovascular and Thoracic Research Coronary Artery Disease Polymorphism SENCR lncRNA |
author_facet |
Nahid Shahmoradi Mahboobeh Nasiri Hajar Kamfiroozi Mohammad Ali Kheiry |
author_sort |
Nahid Shahmoradi |
title |
Association of the rs555172 polymorphism in SENCR long non-coding RNA and atherosclerotic coronary artery disease |
title_short |
Association of the rs555172 polymorphism in SENCR long non-coding RNA and atherosclerotic coronary artery disease |
title_full |
Association of the rs555172 polymorphism in SENCR long non-coding RNA and atherosclerotic coronary artery disease |
title_fullStr |
Association of the rs555172 polymorphism in SENCR long non-coding RNA and atherosclerotic coronary artery disease |
title_full_unstemmed |
Association of the rs555172 polymorphism in SENCR long non-coding RNA and atherosclerotic coronary artery disease |
title_sort |
association of the rs555172 polymorphism in sencr long non-coding rna and atherosclerotic coronary artery disease |
publisher |
Tabriz University of Medical Sciences |
series |
Journal of Cardiovascular and Thoracic Research |
issn |
2008-5117 2008-6830 |
publishDate |
2017-09-01 |
description |
Introduction: Variants in long non-coding RNAs (lncRNAs) have been implicated as potential biomarkers in prediction of complex disorders such as coronary artery disease (CAD). Studies considering the impact of the SENCR antisense lncRNAs on CAD have not established yet in Iranian population. This study aimed to investigate the association between SENCR rs555172 polymorphism and CAD in south Iranian population.
Methods: Amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) was performed to determine the allele and the genotype distribution of SENCR lncRNA polymorphism in 150 patients with CAD compared with 149 healthy controls through this hospital-based case-control study.
Results: The frequency of AA, AG, and GG genotypes in cases were 32.7%, 44.7%, and 22.6%, and in controls were 26.8%, 49%, and 24.2%, respectively. Association was not found with any of the genotypes in comparison of cases and controls. The allelic frequencies did not differ between cases and controls. Cross-tabulating the population based on the gender, the frequency of the GG genotype was significantly higher among women of the case group compared to men. The difference was not seen in the control group between two sexes.
Conclusion: The results suggested that the SENCR gene polymorphism did not confer susceptibility to CAD. |
topic |
Coronary Artery Disease Polymorphism SENCR lncRNA |
url |
http://jcvtr.tbzmed.ac.ir/PDF/JCVTR-9-170.pdf |
work_keys_str_mv |
AT nahidshahmoradi associationofthers555172polymorphisminsencrlongnoncodingrnaandatheroscleroticcoronaryarterydisease AT mahboobehnasiri associationofthers555172polymorphisminsencrlongnoncodingrnaandatheroscleroticcoronaryarterydisease AT hajarkamfiroozi associationofthers555172polymorphisminsencrlongnoncodingrnaandatheroscleroticcoronaryarterydisease AT mohammadalikheiry associationofthers555172polymorphisminsencrlongnoncodingrnaandatheroscleroticcoronaryarterydisease |
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