Targeting the shift from M1 to M2 macrophages in experimental autoimmune encephalomyelitis mice treated with fasudil.
We observed the therapeutic effect of Fasudil and explored its mechanisms in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Fasudil, a selective Rho kinase (ROCK) inhibitor, was injected intraperitoneally at 40 mg/kg/d in early and late stages of EAE ind...
Main Authors: | Chunyun Liu, Yanhua Li, Jiezhong Yu, Ling Feng, Shaowei Hou, Yueting Liu, Mingfang Guo, Yong Xie, Jian Meng, Haifei Zhang, Baoguo Xiao, Cungen Ma |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3572131?pdf=render |
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