Up-Regulation of RIP3 Alleviates Prostate Cancer Progression by Activation of RIP3/MLKL Signaling Pathway and Induction of Necroptosis

Up-Regulation of RIP3 Alleviates Prostate Cancer Progression by Activation of RIP3/MLKL Signaling Pathway and Induction of Necroptosis

BackgroundThe receptor-interacting protein kinase 3 (RIP3/RIPK3) was recently found to be a critical regulator of programmed necrosis/necroptosis. However, the biological role and clinical significance of RIP3 in prostate cancer remain obscure.MethodsWestern blotting and QRT-PCR were performed to de...

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Bibliographic Details
Main Authors: Ke-jie Wang, Kai-yun Wang, Hui-zhi Zhang, Xiang-yu Meng, Jun-feng Chen, Ping Wang, Jun-hui Jiang, Qi Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Oncology
Subjects:
cell death
necroptosis
RIP3
MLKL
prostate cancer
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01720/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.01720/full

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