Up-Regulation of RIP3 Alleviates Prostate Cancer Progression by Activation of RIP3/MLKL Signaling Pathway and Induction of Necroptosis
BackgroundThe receptor-interacting protein kinase 3 (RIP3/RIPK3) was recently found to be a critical regulator of programmed necrosis/necroptosis. However, the biological role and clinical significance of RIP3 in prostate cancer remain obscure.MethodsWestern blotting and QRT-PCR were performed to de...
Main Authors: | Ke-jie Wang, Kai-yun Wang, Hui-zhi Zhang, Xiang-yu Meng, Jun-feng Chen, Ping Wang, Jun-hui Jiang, Qi Ma |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-08-01
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Series: | Frontiers in Oncology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.01720/full |
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