mTORC2 Deficiency Alters the Metabolic Profile of Conventional Dendritic Cells

mTORC2 Deficiency Alters the Metabolic Profile of Conventional Dendritic Cells

In myeloid dendritic cells (DC), deletion of the mechanistic target of rapamycin complex 2 (TORC2) results in an augmented pro-inflammatory phenotype and T cell stimulatory activity; however, the underlying mechanism has not been resolved. Here, we demonstrate that mouse bone marrow-derived TORC2-de...

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Bibliographic Details
Main Authors: Alicia R. Watson, Helong Dai, Yawen Zheng, Ryosuke Nakano, Anastasios D. Giannou, Ashley V. Menk, Donna B. Stolz, Greg M. Delgoffe, Angus W. Thomson
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
mammalian target of rapamycin complex 2
rapamycin
dendritic cells
metabolism
mitochondrial regulation
mouse
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01451/full

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