Diagnostic Value of Procalcitonin and C-Reactive Protein in Diagnosis of Severe Infection in Febrile Neutropenic Patients
Background: The aim of this study was to investigate the sensitivity and specificity of procalcitonin and C-reactive protein in the diagnosis of febrile neutropenic patients in Seyed-Alshohada Hospital (Isfahan, Iran) during 2010-11. Methods: This analytic cross-sectional study included all febrile...
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2012-11-01
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doaj-8d9f30d3e11742e4a323fc85703144542020-11-25T00:02:42ZfasVesnu Publications مجله دانشکده پزشکی اصفهان1027-75951735-854X2012-11-01302041140Diagnostic Value of Procalcitonin and C-Reactive Protein in Diagnosis of Severe Infection in Febrile Neutropenic PatientsMohsen Meidani0Hojat Abolghasemi1Farzin Khorvash2Assistant Professor, Department of Infectious Diseases, School of Medicine AND Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, IranStudent of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Department of Infectious Diseases, School of Medicine AND Nosocomial Infection Disease Research Center, Isfahan University of Medical Sciences, Isfahan, IranBackground: The aim of this study was to investigate the sensitivity and specificity of procalcitonin and C-reactive protein in the diagnosis of febrile neutropenic patients in Seyed-Alshohada Hospital (Isfahan, Iran) during 2010-11. Methods: This analytic cross-sectional study included all febrile neutropenic patients (n = 64) who were admitted in Seyed-Alshohada Hospital during 2010-11. Sex, age, admission time, and duration of fever before taking antibiotics were collected. Patients were then divided to groups with and without severe infection. Findings: The mean levels of procalcitonin in the groups with and without severe infection were 28.65 ± 2.68 and 2.48 ± 0.66 ng/ml, respectively (P < 0.001). The mean levels of C-reactive protein in the groups with and without severe infection were 159.48 ± 9.73 and 126.17 ± 10.63 mg/L, respectively (P = 0.015). Using receiver operating characteristic (ROC) curves, sensitivity and specificity of procalcitonin were determined as 92.5% and 97.3%, respectively. The corresponding values for C-reactive protein were 70.5% and 42.1%. Conclusion: Procalcitonin can be considered as a predictor and diagnostic marker for diagnosis of severe infectious disease. It can also differentiate severe and non-severe disease in febrile neutropenic patients. Nevertheless, clinical signs and symptoms of the disease should also be considered. Keywords: Neutropenia, Fever, Procalcitonin, C-reactive proteinhttp://jims.mui.ac.ir/index.php/jims/article/view/1928 |
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DOAJ |
language |
fas |
format |
Article |
sources |
DOAJ |
author |
Mohsen Meidani Hojat Abolghasemi Farzin Khorvash |
spellingShingle |
Mohsen Meidani Hojat Abolghasemi Farzin Khorvash Diagnostic Value of Procalcitonin and C-Reactive Protein in Diagnosis of Severe Infection in Febrile Neutropenic Patients مجله دانشکده پزشکی اصفهان |
author_facet |
Mohsen Meidani Hojat Abolghasemi Farzin Khorvash |
author_sort |
Mohsen Meidani |
title |
Diagnostic Value of Procalcitonin and C-Reactive Protein in Diagnosis of Severe Infection in Febrile Neutropenic Patients |
title_short |
Diagnostic Value of Procalcitonin and C-Reactive Protein in Diagnosis of Severe Infection in Febrile Neutropenic Patients |
title_full |
Diagnostic Value of Procalcitonin and C-Reactive Protein in Diagnosis of Severe Infection in Febrile Neutropenic Patients |
title_fullStr |
Diagnostic Value of Procalcitonin and C-Reactive Protein in Diagnosis of Severe Infection in Febrile Neutropenic Patients |
title_full_unstemmed |
Diagnostic Value of Procalcitonin and C-Reactive Protein in Diagnosis of Severe Infection in Febrile Neutropenic Patients |
title_sort |
diagnostic value of procalcitonin and c-reactive protein in diagnosis of severe infection in febrile neutropenic patients |
publisher |
Vesnu Publications |
series |
مجله دانشکده پزشکی اصفهان |
issn |
1027-7595 1735-854X |
publishDate |
2012-11-01 |
description |
Background: The aim of this study was to investigate the sensitivity and specificity of procalcitonin and C-reactive protein in the diagnosis of febrile neutropenic patients in Seyed-Alshohada Hospital (Isfahan, Iran) during 2010-11.
Methods: This analytic cross-sectional study included all febrile neutropenic patients (n = 64) who were admitted in Seyed-Alshohada Hospital during 2010-11. Sex, age, admission time, and duration of fever before taking antibiotics were collected. Patients were then divided to groups with and without severe infection.
Findings: The mean levels of procalcitonin in the groups with and without severe infection were 28.65 ± 2.68 and 2.48 ± 0.66 ng/ml, respectively (P < 0.001). The mean levels of C-reactive protein in the groups with and without severe infection were 159.48 ± 9.73 and 126.17 ± 10.63 mg/L, respectively (P = 0.015). Using receiver operating characteristic (ROC) curves, sensitivity and specificity of procalcitonin were determined as 92.5% and 97.3%, respectively. The corresponding values for C-reactive protein were 70.5% and 42.1%.
Conclusion: Procalcitonin can be considered as a predictor and diagnostic marker for diagnosis of severe infectious disease. It can also differentiate severe and non-severe disease in febrile neutropenic patients. Nevertheless, clinical signs and symptoms of the disease should also be considered.
Keywords: Neutropenia, Fever, Procalcitonin, C-reactive protein |
url |
http://jims.mui.ac.ir/index.php/jims/article/view/1928 |
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