Porous Poly(Hexamethylene Biguanide) Hydrochloride Loaded Silk Fibroin Sponges with Antibacterial Function
In order to endue silk fibroin (SF) sponges with antibacterial function, positively charged poly(hexamethylene biguanide) hydrochloride (PHMB) was incorporated in SF through electrostatic interaction and by freeze-drying technique. The influence of PHMB on the structure and antibacterial activities...
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doaj-8da60fa8a8294c00b84b5371ec9202e72020-11-25T01:12:57ZengMDPI AGMaterials1996-19442020-01-0113228510.3390/ma13020285ma13020285Porous Poly(Hexamethylene Biguanide) Hydrochloride Loaded Silk Fibroin Sponges with Antibacterial FunctionAhui Liang0Min Zhang1Hong Luo2Longxing Niu3Yanfei Feng4Mingzhong Li5National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, ChinaNational Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, ChinaNational Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, ChinaNational Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, ChinaNational Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, ChinaNational Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, ChinaIn order to endue silk fibroin (SF) sponges with antibacterial function, positively charged poly(hexamethylene biguanide) hydrochloride (PHMB) was incorporated in SF through electrostatic interaction and by freeze-drying technique. The influence of PHMB on the structure and antibacterial activities of SF sponges was investigated. The zeta potential of SF was increased significantly when PHMB was incorporated in SF. The pores with size from 80 to 300 µm and the microscale holes in the pore walls within PHMB-loaded SF sponges provided the channels of PHMB release. The PHMB loaded in the porous sponges showed continuous and slow release for up to 20 days. Effective growth inhibition of both <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> was achieved when the mass ratio of PHMB/SF was higher than 2/100. These results suggest that the porous PHMB/SF sponges have the potential to be used as a novel wound dressing for open skin wounds.https://www.mdpi.com/1996-1944/13/2/285silk fibroinpoly(hexamethylene biguanide) hydrochloridespongesantibacterial materials |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ahui Liang Min Zhang Hong Luo Longxing Niu Yanfei Feng Mingzhong Li |
spellingShingle |
Ahui Liang Min Zhang Hong Luo Longxing Niu Yanfei Feng Mingzhong Li Porous Poly(Hexamethylene Biguanide) Hydrochloride Loaded Silk Fibroin Sponges with Antibacterial Function Materials silk fibroin poly(hexamethylene biguanide) hydrochloride sponges antibacterial materials |
author_facet |
Ahui Liang Min Zhang Hong Luo Longxing Niu Yanfei Feng Mingzhong Li |
author_sort |
Ahui Liang |
title |
Porous Poly(Hexamethylene Biguanide) Hydrochloride Loaded Silk Fibroin Sponges with Antibacterial Function |
title_short |
Porous Poly(Hexamethylene Biguanide) Hydrochloride Loaded Silk Fibroin Sponges with Antibacterial Function |
title_full |
Porous Poly(Hexamethylene Biguanide) Hydrochloride Loaded Silk Fibroin Sponges with Antibacterial Function |
title_fullStr |
Porous Poly(Hexamethylene Biguanide) Hydrochloride Loaded Silk Fibroin Sponges with Antibacterial Function |
title_full_unstemmed |
Porous Poly(Hexamethylene Biguanide) Hydrochloride Loaded Silk Fibroin Sponges with Antibacterial Function |
title_sort |
porous poly(hexamethylene biguanide) hydrochloride loaded silk fibroin sponges with antibacterial function |
publisher |
MDPI AG |
series |
Materials |
issn |
1996-1944 |
publishDate |
2020-01-01 |
description |
In order to endue silk fibroin (SF) sponges with antibacterial function, positively charged poly(hexamethylene biguanide) hydrochloride (PHMB) was incorporated in SF through electrostatic interaction and by freeze-drying technique. The influence of PHMB on the structure and antibacterial activities of SF sponges was investigated. The zeta potential of SF was increased significantly when PHMB was incorporated in SF. The pores with size from 80 to 300 µm and the microscale holes in the pore walls within PHMB-loaded SF sponges provided the channels of PHMB release. The PHMB loaded in the porous sponges showed continuous and slow release for up to 20 days. Effective growth inhibition of both <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> was achieved when the mass ratio of PHMB/SF was higher than 2/100. These results suggest that the porous PHMB/SF sponges have the potential to be used as a novel wound dressing for open skin wounds. |
topic |
silk fibroin poly(hexamethylene biguanide) hydrochloride sponges antibacterial materials |
url |
https://www.mdpi.com/1996-1944/13/2/285 |
work_keys_str_mv |
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