Plasmacytoid urothelial carcinoma of renal pelvis with positive zinc finger E–box–binding homeobox 1: a case report
Abstract Background The tumor transformation mechanism of a plasmacytoid urothelial carcinoma remains unexplained. We describe the case of a plasmacytoid urothelial carcinoma of the renal pelvis in which the expression of zinc finger E–box–binding homeobox 1 (ZEB1), a key nuclear transcription facto...
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doaj-8db742e3ee704fb38a7e25a674d1128e2020-11-25T03:06:50ZengBMCDiagnostic Pathology1746-15962020-10-011511510.1186/s13000-020-01043-6Plasmacytoid urothelial carcinoma of renal pelvis with positive zinc finger E–box–binding homeobox 1: a case reportAtsuko Takada-Owada0Yumi Nozawa1Masato Onozaki2Shuhei Noda3Tsengelmaa Jamiyan4Yuumi Tokura5Yoshimasa Nakazato6Takao Kamai7Kazuyuki Ishida8Department of Diagnostic Pathology, Dokkyo Medical UniversityDepartment of Diagnostic Pathology, Dokkyo Medical UniversityDepartment of Diagnostic Pathology, Dokkyo Medical UniversityDepartment of Diagnostic Pathology, Dokkyo Medical UniversityDepartment of Diagnostic Pathology, Dokkyo Medical UniversityDepartment of Urology, Dokkyo Medical UniversityDepartment of Diagnostic Pathology, Dokkyo Medical UniversityDepartment of Urology, Dokkyo Medical UniversityDepartment of Diagnostic Pathology, Dokkyo Medical UniversityAbstract Background The tumor transformation mechanism of a plasmacytoid urothelial carcinoma remains unexplained. We describe the case of a plasmacytoid urothelial carcinoma of the renal pelvis in which the expression of zinc finger E–box–binding homeobox 1 (ZEB1), a key nuclear transcription factor in an epithelial–mesenchymal transition, is involved in tumor transformation. Case presentation The patient had a left nephrectomy with the clinical diagnosis of left pelvic renal cancer. The resected specimen showed that the tumor surface comprised a noninvasive papillary urothelial carcinoma with the carcinoma in situ, and the invasive area comprised a plasmacytoid urothelial carcinoma characterized by the presence of single dyscohesive malignant cells that resembled plasma cells in a loose myxoid stroma. The noninvasive urothelial carcinoma was positive for cytokeratin and E–cadherin, and negative for vimentin and ZEB1. In contrast, the invasive plasmacytoid urothelial carcinoma was positive for cytokeratin and also vimentin and ZEB1, and negative for E–cadherin. Additionally, this component was immunoreactive for CD138 and CD38 that are immunohistochemical markers for plasma cells. Conclusion We suggest that ZEB1 is involved in the plasmacytoid transformation by repressing the E–cadherin in a plasmacytoid urothelial carcinoma.http://link.springer.com/article/10.1186/s13000-020-01043-6Plasmacytoid urothelial carcinomaCD38CD138Epithelial–mesenchymal transitionZinc finger e–box–binding homeobox 1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Atsuko Takada-Owada Yumi Nozawa Masato Onozaki Shuhei Noda Tsengelmaa Jamiyan Yuumi Tokura Yoshimasa Nakazato Takao Kamai Kazuyuki Ishida |
spellingShingle |
Atsuko Takada-Owada Yumi Nozawa Masato Onozaki Shuhei Noda Tsengelmaa Jamiyan Yuumi Tokura Yoshimasa Nakazato Takao Kamai Kazuyuki Ishida Plasmacytoid urothelial carcinoma of renal pelvis with positive zinc finger E–box–binding homeobox 1: a case report Diagnostic Pathology Plasmacytoid urothelial carcinoma CD38 CD138 Epithelial–mesenchymal transition Zinc finger e–box–binding homeobox 1 |
author_facet |
Atsuko Takada-Owada Yumi Nozawa Masato Onozaki Shuhei Noda Tsengelmaa Jamiyan Yuumi Tokura Yoshimasa Nakazato Takao Kamai Kazuyuki Ishida |
author_sort |
Atsuko Takada-Owada |
title |
Plasmacytoid urothelial carcinoma of renal pelvis with positive zinc finger E–box–binding homeobox 1: a case report |
title_short |
Plasmacytoid urothelial carcinoma of renal pelvis with positive zinc finger E–box–binding homeobox 1: a case report |
title_full |
Plasmacytoid urothelial carcinoma of renal pelvis with positive zinc finger E–box–binding homeobox 1: a case report |
title_fullStr |
Plasmacytoid urothelial carcinoma of renal pelvis with positive zinc finger E–box–binding homeobox 1: a case report |
title_full_unstemmed |
Plasmacytoid urothelial carcinoma of renal pelvis with positive zinc finger E–box–binding homeobox 1: a case report |
title_sort |
plasmacytoid urothelial carcinoma of renal pelvis with positive zinc finger e–box–binding homeobox 1: a case report |
publisher |
BMC |
series |
Diagnostic Pathology |
issn |
1746-1596 |
publishDate |
2020-10-01 |
description |
Abstract Background The tumor transformation mechanism of a plasmacytoid urothelial carcinoma remains unexplained. We describe the case of a plasmacytoid urothelial carcinoma of the renal pelvis in which the expression of zinc finger E–box–binding homeobox 1 (ZEB1), a key nuclear transcription factor in an epithelial–mesenchymal transition, is involved in tumor transformation. Case presentation The patient had a left nephrectomy with the clinical diagnosis of left pelvic renal cancer. The resected specimen showed that the tumor surface comprised a noninvasive papillary urothelial carcinoma with the carcinoma in situ, and the invasive area comprised a plasmacytoid urothelial carcinoma characterized by the presence of single dyscohesive malignant cells that resembled plasma cells in a loose myxoid stroma. The noninvasive urothelial carcinoma was positive for cytokeratin and E–cadherin, and negative for vimentin and ZEB1. In contrast, the invasive plasmacytoid urothelial carcinoma was positive for cytokeratin and also vimentin and ZEB1, and negative for E–cadherin. Additionally, this component was immunoreactive for CD138 and CD38 that are immunohistochemical markers for plasma cells. Conclusion We suggest that ZEB1 is involved in the plasmacytoid transformation by repressing the E–cadherin in a plasmacytoid urothelial carcinoma. |
topic |
Plasmacytoid urothelial carcinoma CD38 CD138 Epithelial–mesenchymal transition Zinc finger e–box–binding homeobox 1 |
url |
http://link.springer.com/article/10.1186/s13000-020-01043-6 |
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