Asiatic Acid Protects against Doxorubicin-Induced Cardiotoxicity in Mice
The use of doxorubicin (DOX) can result in depression of cardiac function and refractory cardiomyopathy. Currently, there are no effective approaches to prevent DOX-related cardiac complications. Asiatic acid (AA) has been reported to provide cardioprotection against several cardiovascular diseases....
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Hindawi Limited
2020-01-01
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Series: | Oxidative Medicine and Cellular Longevity |
Online Access: | http://dx.doi.org/10.1155/2020/5347204 |
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doaj-8dd6cb53e91d47c4b06fcb2d9f1fffd02020-11-25T02:33:30ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942020-01-01202010.1155/2020/53472045347204Asiatic Acid Protects against Doxorubicin-Induced Cardiotoxicity in MiceXiaoping Hu0Baijun Li1Luocheng Li2Bowen Li3Jinlong Luo4Bin Shen5Department of Cardiovascular Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, ChinaDepartment of Thoracic Cardiovascular Surgery, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi Zhuang Autonomous Region, ChinaDepartment of Cardiovascular Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, ChinaDepartment of Cardiovascular Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, ChinaDepartment of Thoracic Cardiovascular Surgery, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi Zhuang Autonomous Region, ChinaDepartment of Thoracic Cardiovascular Surgery, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi Zhuang Autonomous Region, ChinaThe use of doxorubicin (DOX) can result in depression of cardiac function and refractory cardiomyopathy. Currently, there are no effective approaches to prevent DOX-related cardiac complications. Asiatic acid (AA) has been reported to provide cardioprotection against several cardiovascular diseases. However, whether AA could attenuate DOX-related cardiac injury remains unclear. DOX (15 mg/kg) was injected intraperitoneally into the mice to mimic acute cardiac injury, and the mice were given AA (10 mg/kg or 30 mg/kg) for 2 weeks for protection. The data in our study found that AA-treated mice exhibited attenuated cardiac injury and improved cardiac function in response to DOX injection. AA also suppressed myocardial oxidative damage and apoptosis without affecting cardiac inflammation in DOX-treated mice. AA also provided protection in DOX-challenged cardiomyocytes, improved cell viability, and suppressed intracellular reactive oxygen species (ROS) in vitro. Detection of signaling pathways showed that AA activated protein kinase B (AKT) signaling pathway in vivo and in vitro. Furthermore, we found that AA lost its protective effects in the heart with AKT inactivation. In conclusion, our results found that AA could attenuate DOX-induced myocardial oxidative stress and apoptosis via activation of the AKT signaling pathway.http://dx.doi.org/10.1155/2020/5347204 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiaoping Hu Baijun Li Luocheng Li Bowen Li Jinlong Luo Bin Shen |
spellingShingle |
Xiaoping Hu Baijun Li Luocheng Li Bowen Li Jinlong Luo Bin Shen Asiatic Acid Protects against Doxorubicin-Induced Cardiotoxicity in Mice Oxidative Medicine and Cellular Longevity |
author_facet |
Xiaoping Hu Baijun Li Luocheng Li Bowen Li Jinlong Luo Bin Shen |
author_sort |
Xiaoping Hu |
title |
Asiatic Acid Protects against Doxorubicin-Induced Cardiotoxicity in Mice |
title_short |
Asiatic Acid Protects against Doxorubicin-Induced Cardiotoxicity in Mice |
title_full |
Asiatic Acid Protects against Doxorubicin-Induced Cardiotoxicity in Mice |
title_fullStr |
Asiatic Acid Protects against Doxorubicin-Induced Cardiotoxicity in Mice |
title_full_unstemmed |
Asiatic Acid Protects against Doxorubicin-Induced Cardiotoxicity in Mice |
title_sort |
asiatic acid protects against doxorubicin-induced cardiotoxicity in mice |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0900 1942-0994 |
publishDate |
2020-01-01 |
description |
The use of doxorubicin (DOX) can result in depression of cardiac function and refractory cardiomyopathy. Currently, there are no effective approaches to prevent DOX-related cardiac complications. Asiatic acid (AA) has been reported to provide cardioprotection against several cardiovascular diseases. However, whether AA could attenuate DOX-related cardiac injury remains unclear. DOX (15 mg/kg) was injected intraperitoneally into the mice to mimic acute cardiac injury, and the mice were given AA (10 mg/kg or 30 mg/kg) for 2 weeks for protection. The data in our study found that AA-treated mice exhibited attenuated cardiac injury and improved cardiac function in response to DOX injection. AA also suppressed myocardial oxidative damage and apoptosis without affecting cardiac inflammation in DOX-treated mice. AA also provided protection in DOX-challenged cardiomyocytes, improved cell viability, and suppressed intracellular reactive oxygen species (ROS) in vitro. Detection of signaling pathways showed that AA activated protein kinase B (AKT) signaling pathway in vivo and in vitro. Furthermore, we found that AA lost its protective effects in the heart with AKT inactivation. In conclusion, our results found that AA could attenuate DOX-induced myocardial oxidative stress and apoptosis via activation of the AKT signaling pathway. |
url |
http://dx.doi.org/10.1155/2020/5347204 |
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