The relationship between the polymorphisms of the gene and hypertension: A meta-analysis
Objective: With the development of genome-wide association studies (GWAS) concerning hypertension, a growing number of susceptibility genes related to hypertension have been revealed. Subsequently, several studies have investigated the association between CYP17A1 rs1004467 heritable variation and hy...
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2015-12-01
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Series: | Journal of the Renin-Angiotensin-Aldosterone System |
Online Access: | https://doi.org/10.1177/1470320315585683 |
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doaj-8dd756511b8548d48e6f143e31310f672021-05-02T14:45:29ZengHindawi - SAGE PublishingJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762015-12-011610.1177/1470320315585683The relationship between the polymorphisms of the gene and hypertension: A meta-analysisChuan-Fang DaiXiang XieYi-Tong MaYi-Ning YangXiao-Mei LiZhen-Yan FuFen LiuBang-Dang ChenMin-Tao GaiObjective: With the development of genome-wide association studies (GWAS) concerning hypertension, a growing number of susceptibility genes related to hypertension have been revealed. Subsequently, several studies have investigated the association between CYP17A1 rs1004467 heritable variation and hypertension; however, the results have been inconsistent. In this study, a meta-analysis was performed to assess the association between the CYP17A1 rs1004467 polymorphism and hypertension risk. Methods: The PubMed, ISI Web of Science and Embase databases as well as China Wanfang, Weipu and the Chinese Journal Full-text Database were used to retrieve all publications from 2005 to 2013 related to case-control studies that reported a link between the risk factors for hypertension and the CYP17A1 polymorphism. All association studies were identified, and a meta-analysis was conducted using the RevMan 5.0 estimate for odds ratios (ORs) to determine whether the A allele predicts hypertension outcomes. Results: Three articles including five studies (totaling 4495 patients and 3529 controls) were identified. The overall effect suggested that rs1004467 was significantly associated with hypertension (OR=1.22, 95%CI 1.08–1.38, p =0.001). Conclusions: The present meta-analysis confirmed the significant association between a polymorphism of the CYP17A1 gene and hypertension susceptibility. The CYP17A1 A allele should be considered a risk factor for hypertension.https://doi.org/10.1177/1470320315585683 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chuan-Fang Dai Xiang Xie Yi-Tong Ma Yi-Ning Yang Xiao-Mei Li Zhen-Yan Fu Fen Liu Bang-Dang Chen Min-Tao Gai |
spellingShingle |
Chuan-Fang Dai Xiang Xie Yi-Tong Ma Yi-Ning Yang Xiao-Mei Li Zhen-Yan Fu Fen Liu Bang-Dang Chen Min-Tao Gai The relationship between the polymorphisms of the gene and hypertension: A meta-analysis Journal of the Renin-Angiotensin-Aldosterone System |
author_facet |
Chuan-Fang Dai Xiang Xie Yi-Tong Ma Yi-Ning Yang Xiao-Mei Li Zhen-Yan Fu Fen Liu Bang-Dang Chen Min-Tao Gai |
author_sort |
Chuan-Fang Dai |
title |
The relationship between the polymorphisms of the gene and hypertension: A meta-analysis |
title_short |
The relationship between the polymorphisms of the gene and hypertension: A meta-analysis |
title_full |
The relationship between the polymorphisms of the gene and hypertension: A meta-analysis |
title_fullStr |
The relationship between the polymorphisms of the gene and hypertension: A meta-analysis |
title_full_unstemmed |
The relationship between the polymorphisms of the gene and hypertension: A meta-analysis |
title_sort |
relationship between the polymorphisms of the gene and hypertension: a meta-analysis |
publisher |
Hindawi - SAGE Publishing |
series |
Journal of the Renin-Angiotensin-Aldosterone System |
issn |
1470-3203 1752-8976 |
publishDate |
2015-12-01 |
description |
Objective: With the development of genome-wide association studies (GWAS) concerning hypertension, a growing number of susceptibility genes related to hypertension have been revealed. Subsequently, several studies have investigated the association between CYP17A1 rs1004467 heritable variation and hypertension; however, the results have been inconsistent. In this study, a meta-analysis was performed to assess the association between the CYP17A1 rs1004467 polymorphism and hypertension risk. Methods: The PubMed, ISI Web of Science and Embase databases as well as China Wanfang, Weipu and the Chinese Journal Full-text Database were used to retrieve all publications from 2005 to 2013 related to case-control studies that reported a link between the risk factors for hypertension and the CYP17A1 polymorphism. All association studies were identified, and a meta-analysis was conducted using the RevMan 5.0 estimate for odds ratios (ORs) to determine whether the A allele predicts hypertension outcomes. Results: Three articles including five studies (totaling 4495 patients and 3529 controls) were identified. The overall effect suggested that rs1004467 was significantly associated with hypertension (OR=1.22, 95%CI 1.08–1.38, p =0.001). Conclusions: The present meta-analysis confirmed the significant association between a polymorphism of the CYP17A1 gene and hypertension susceptibility. The CYP17A1 A allele should be considered a risk factor for hypertension. |
url |
https://doi.org/10.1177/1470320315585683 |
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