Telomere Transcripts Target Telomerase in Human Cancer Cells

Telomere Transcripts Target Telomerase in Human Cancer Cells

Long non-coding transcripts from telomeres, called telomeric repeat-containing RNA (TERRA), were identified as blocking telomerase activity (TA), a telomere maintenance mechanism (TMM), in tumors. We expressed recombinant TERRA transcripts in tumor cell lines with TA and with alternative lengthening...

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Bibliographic Details
Main Authors: Theresa Kreilmeier, Doris Mejri, Marlene Hauck, Miriam Kleiter, Klaus Holzmann
Format: Article
Language:English
Published: MDPI AG 2016-08-01
Series:Genes
Subjects:
telomerase
enzyme inhibition
telomere
long non-coding transcript
viral expression systems
tumor cell lines
human
canine
Online Access:http://www.mdpi.com/2073-4425/7/8/46

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