A key role of the prefrontal cortex in the maintenance of chronic tinnitus: An fMRI study using a Stroop task
Introduction: Since we recently showed in behavioural tasks that the top-down cognitive control was specifically altered in tinnitus sufferers, here we wanted to establish the link between this impaired executive function and brain alterations in the frontal cortex in tinnitus patients. Method: Usin...
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doaj-8df29c1d8ad9492689307984a554164a2020-11-24T21:19:13ZengElsevierNeuroImage: Clinical2213-15822018-01-0117325334A key role of the prefrontal cortex in the maintenance of chronic tinnitus: An fMRI study using a Stroop taskRodrigo Araneda0Laurent Renier1Laurence Dricot2Monique Decat3Daniela Ebner-Karestinos4Naïma Deggouj5Anne G. De Volder6Institute of Neuroscience, MSL-IN Lab., Université Catholique de Louvain, BelgiumInstitute of Neuroscience, MSL-IN Lab., Université Catholique de Louvain, BelgiumInstitute of Neuroscience, MSL-IN Lab., Université Catholique de Louvain, BelgiumDepartment of Oto-Rhino-Laryngology & Head and Neck Surgery, Université Catholique de Louvain and Cliniques Universitaires St-Luc, BelgiumInstitute of Neuroscience, MSL-IN Lab., Université Catholique de Louvain, BelgiumInstitute of Neuroscience, MSL-IN Lab., Université Catholique de Louvain, Belgium; Department of Oto-Rhino-Laryngology & Head and Neck Surgery, Université Catholique de Louvain and Cliniques Universitaires St-Luc, BelgiumInstitute of Neuroscience, MSL-IN Lab., Université Catholique de Louvain, Belgium; Corresponding author at: UCL/IoNS/MSL-IN Lab., Avenue Hippocrate, 54, UCL-B1.54.09, B-1200 Brussels, Belgium.Introduction: Since we recently showed in behavioural tasks that the top-down cognitive control was specifically altered in tinnitus sufferers, here we wanted to establish the link between this impaired executive function and brain alterations in the frontal cortex in tinnitus patients. Method: Using functional magnetic resonance imaging (fMRI), we monitored the brain activity changes in sixteen tinnitus patients (TP) and their control subjects (CS) while they were performing a spatial Stroop task, both in audition and vision. Results: We observed that TP differed from CS in their functional recruitment of the dorsolateral prefrontal cortex (dlPFC, BA46), the cingulate gyrus and the ventromedial prefrontal cortex (vmPFC, BA10). This recruitment was higher during interference conditions in tinnitus participants than in controls, whatever the sensory modality. Furthermore, the brain activity level in the right dlPFC and vmPFC correlated with the performance in the Stroop task in TP. Conclusion: Due to the direct link between poor executive functions and prefrontal cortex alterations in TP, we postulate that a lack of inhibitory modulation following an impaired top-down cognitive control may maintain tinnitus by hampering habituation mechanisms. This deficit in executive functions caused by prefrontal cortex alterations would be a key-factor in the generation and persistence of tinnitus. Keywords: fMRI, Prefrontal cortex, Tinnitushttp://www.sciencedirect.com/science/article/pii/S2213158217302693 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rodrigo Araneda Laurent Renier Laurence Dricot Monique Decat Daniela Ebner-Karestinos Naïma Deggouj Anne G. De Volder |
spellingShingle |
Rodrigo Araneda Laurent Renier Laurence Dricot Monique Decat Daniela Ebner-Karestinos Naïma Deggouj Anne G. De Volder A key role of the prefrontal cortex in the maintenance of chronic tinnitus: An fMRI study using a Stroop task NeuroImage: Clinical |
author_facet |
Rodrigo Araneda Laurent Renier Laurence Dricot Monique Decat Daniela Ebner-Karestinos Naïma Deggouj Anne G. De Volder |
author_sort |
Rodrigo Araneda |
title |
A key role of the prefrontal cortex in the maintenance of chronic tinnitus: An fMRI study using a Stroop task |
title_short |
A key role of the prefrontal cortex in the maintenance of chronic tinnitus: An fMRI study using a Stroop task |
title_full |
A key role of the prefrontal cortex in the maintenance of chronic tinnitus: An fMRI study using a Stroop task |
title_fullStr |
A key role of the prefrontal cortex in the maintenance of chronic tinnitus: An fMRI study using a Stroop task |
title_full_unstemmed |
A key role of the prefrontal cortex in the maintenance of chronic tinnitus: An fMRI study using a Stroop task |
title_sort |
key role of the prefrontal cortex in the maintenance of chronic tinnitus: an fmri study using a stroop task |
publisher |
Elsevier |
series |
NeuroImage: Clinical |
issn |
2213-1582 |
publishDate |
2018-01-01 |
description |
Introduction: Since we recently showed in behavioural tasks that the top-down cognitive control was specifically altered in tinnitus sufferers, here we wanted to establish the link between this impaired executive function and brain alterations in the frontal cortex in tinnitus patients. Method: Using functional magnetic resonance imaging (fMRI), we monitored the brain activity changes in sixteen tinnitus patients (TP) and their control subjects (CS) while they were performing a spatial Stroop task, both in audition and vision. Results: We observed that TP differed from CS in their functional recruitment of the dorsolateral prefrontal cortex (dlPFC, BA46), the cingulate gyrus and the ventromedial prefrontal cortex (vmPFC, BA10). This recruitment was higher during interference conditions in tinnitus participants than in controls, whatever the sensory modality. Furthermore, the brain activity level in the right dlPFC and vmPFC correlated with the performance in the Stroop task in TP. Conclusion: Due to the direct link between poor executive functions and prefrontal cortex alterations in TP, we postulate that a lack of inhibitory modulation following an impaired top-down cognitive control may maintain tinnitus by hampering habituation mechanisms. This deficit in executive functions caused by prefrontal cortex alterations would be a key-factor in the generation and persistence of tinnitus. Keywords: fMRI, Prefrontal cortex, Tinnitus |
url |
http://www.sciencedirect.com/science/article/pii/S2213158217302693 |
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