Recent Advances in Shiga Toxin-Producing Escherichia coli Research in Latin America
Pathogenic Escherichia coli are known to be a common cause of diarrheal disease and a frequently occurring bacterial infection in children and adults in Latin America. Despite the effort to combat diarrheal infections, the south of the American continent remains a hot spot for infections and sequela...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2018-09-01
|
Series: | Microorganisms |
Subjects: | |
Online Access: | http://www.mdpi.com/2076-2607/6/4/100 |
id |
doaj-8df906eae0c6443482b786ba5694071d |
---|---|
record_format |
Article |
spelling |
doaj-8df906eae0c6443482b786ba5694071d2020-11-24T20:51:44ZengMDPI AGMicroorganisms2076-26072018-09-016410010.3390/microorganisms6040100microorganisms6040100Recent Advances in Shiga Toxin-Producing Escherichia coli Research in Latin AmericaAlfredo G. Torres0Maria M. Amaral1Leticia Bentancor2Lucia Galli3Jorge Goldstein4Alejandra Krüger5Maricarmen Rojas-Lopez6Department of Microbiology and Immunology, Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX 77555, USALaboratorio de Fisiopatogenia, Departamento de Fisiología, Instituto de Fisiología y Biofísica Bernardo Houssay, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121ABG, ArgentinaLaboratory of Genetic Engineering and Molecular Biology, Institute of Basic and Applied Microbiology, National University of Quilmes, Bernal, Buenos Aires 1876, ArgentinaInstituto de Genética Veterinaria Ing. Fernando N. Dulout (UNLP-CONICET, La Plata), Facultad de Ciencias Veterinarias, La Plata 1900, ArgentinaConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Fisiología y Biofísica Houssay, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121ABG, ArgentinaCentro de Investigación Veterinaria de Tandil (CONICET-CIC-UNCPBA), Facultad de Ciencias Veterinarias, Tandil 7000, ArgentinaDepartment of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USAPathogenic Escherichia coli are known to be a common cause of diarrheal disease and a frequently occurring bacterial infection in children and adults in Latin America. Despite the effort to combat diarrheal infections, the south of the American continent remains a hot spot for infections and sequelae associated with the acquisition of one category of pathogenic E. coli, the Shiga toxin-producing E. coli (STEC). This review will focus on an overview of the prevalence of different STEC serotypes in human, animals and food products, focusing on recent reports from Latin America outlining the recent research progress achieved in this region to combat disease and endemicity in affected countries and to improve understanding on emerging serotypes and their virulence factors. Furthermore, this review will highlight the progress done in vaccine development and treatment and will also discuss the effort of the Latin American investigators to respond to the thread of STEC infections by establishing a multidisciplinary network of experts that are addressing STEC-associated animal, human and environmental health issues, while trying to reduce human disease. Regardless of the significant scientific contributions to understand and combat STEC infections worldwide, many significant challenges still exist and this review has focus in the Latin American efforts as an example of what can be accomplished when multiple groups have a common goal.http://www.mdpi.com/2076-2607/6/4/100Shiga toxinSTECShiga toxin-producing E. colienterohemorrhagic E. colihemolytic uremic syndromediarrheavaccinestherapeuticsphages |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alfredo G. Torres Maria M. Amaral Leticia Bentancor Lucia Galli Jorge Goldstein Alejandra Krüger Maricarmen Rojas-Lopez |
spellingShingle |
Alfredo G. Torres Maria M. Amaral Leticia Bentancor Lucia Galli Jorge Goldstein Alejandra Krüger Maricarmen Rojas-Lopez Recent Advances in Shiga Toxin-Producing Escherichia coli Research in Latin America Microorganisms Shiga toxin STEC Shiga toxin-producing E. coli enterohemorrhagic E. coli hemolytic uremic syndrome diarrhea vaccines therapeutics phages |
author_facet |
Alfredo G. Torres Maria M. Amaral Leticia Bentancor Lucia Galli Jorge Goldstein Alejandra Krüger Maricarmen Rojas-Lopez |
author_sort |
Alfredo G. Torres |
title |
Recent Advances in Shiga Toxin-Producing Escherichia coli Research in Latin America |
title_short |
Recent Advances in Shiga Toxin-Producing Escherichia coli Research in Latin America |
title_full |
Recent Advances in Shiga Toxin-Producing Escherichia coli Research in Latin America |
title_fullStr |
Recent Advances in Shiga Toxin-Producing Escherichia coli Research in Latin America |
title_full_unstemmed |
Recent Advances in Shiga Toxin-Producing Escherichia coli Research in Latin America |
title_sort |
recent advances in shiga toxin-producing escherichia coli research in latin america |
publisher |
MDPI AG |
series |
Microorganisms |
issn |
2076-2607 |
publishDate |
2018-09-01 |
description |
Pathogenic Escherichia coli are known to be a common cause of diarrheal disease and a frequently occurring bacterial infection in children and adults in Latin America. Despite the effort to combat diarrheal infections, the south of the American continent remains a hot spot for infections and sequelae associated with the acquisition of one category of pathogenic E. coli, the Shiga toxin-producing E. coli (STEC). This review will focus on an overview of the prevalence of different STEC serotypes in human, animals and food products, focusing on recent reports from Latin America outlining the recent research progress achieved in this region to combat disease and endemicity in affected countries and to improve understanding on emerging serotypes and their virulence factors. Furthermore, this review will highlight the progress done in vaccine development and treatment and will also discuss the effort of the Latin American investigators to respond to the thread of STEC infections by establishing a multidisciplinary network of experts that are addressing STEC-associated animal, human and environmental health issues, while trying to reduce human disease. Regardless of the significant scientific contributions to understand and combat STEC infections worldwide, many significant challenges still exist and this review has focus in the Latin American efforts as an example of what can be accomplished when multiple groups have a common goal. |
topic |
Shiga toxin STEC Shiga toxin-producing E. coli enterohemorrhagic E. coli hemolytic uremic syndrome diarrhea vaccines therapeutics phages |
url |
http://www.mdpi.com/2076-2607/6/4/100 |
work_keys_str_mv |
AT alfredogtorres recentadvancesinshigatoxinproducingescherichiacoliresearchinlatinamerica AT mariamamaral recentadvancesinshigatoxinproducingescherichiacoliresearchinlatinamerica AT leticiabentancor recentadvancesinshigatoxinproducingescherichiacoliresearchinlatinamerica AT luciagalli recentadvancesinshigatoxinproducingescherichiacoliresearchinlatinamerica AT jorgegoldstein recentadvancesinshigatoxinproducingescherichiacoliresearchinlatinamerica AT alejandrakruger recentadvancesinshigatoxinproducingescherichiacoliresearchinlatinamerica AT maricarmenrojaslopez recentadvancesinshigatoxinproducingescherichiacoliresearchinlatinamerica |
_version_ |
1716801432510791680 |