Interaction of microRNAs with sphingosine kinases, sphingosine-1 phosphate, and sphingosine-1 phosphate receptors in cancer

Interaction of microRNAs with sphingosine kinases, sphingosine-1 phosphate, and sphingosine-1 phosphate receptors in cancer

Abstract Sphingosine-1-phosphate (S1P), a pleiotropic lipid mediator, participates in various cellular processes during tumorigenesis, including cell proliferation, survival, drug resistance, metastasis, and angiogenesis. S1P is formed by two sphingosine kinases (SphKs), SphK1 and SphK2. The intrace...

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Bibliographic Details
Main Authors: Guangmeng Xu, Zecheng Yang, Yamin Sun, Hongmei Dong, Jingru Ma
Format: Article
Language:English
Published: Springer 2021-09-01
Series:Discover Oncology
Subjects:
Sphingosine-1-phosphate (S1P)
Metastasis
Angiogenesis
MicroRNAs
Cancer
Online Access:https://doi.org/10.1007/s12672-021-00430-9

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