Nitric oxide and pulmonary hypertension
Pulmonary hypertension is a serious complication of a number of lung and heart diseases that is characterized by peripheral vascular structural remodeling and loss of vascular tone. Nitric oxide can modulate vascular injury and interrupt elevation of pulmonary vascular resistance selectively; howeve...
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doaj-8e004fdf087645678c93fc1126f432b82020-11-25T04:05:20ZengKorean Society of AnesthesiologistsKorean Journal of Anesthesiology2005-64192005-75632010-01-0158141410.4097/kjae.2010.58.1.46890Nitric oxide and pulmonary hypertensionJi-Yeon Sim0Department of Anesthesiology and Pain Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.Pulmonary hypertension is a serious complication of a number of lung and heart diseases that is characterized by peripheral vascular structural remodeling and loss of vascular tone. Nitric oxide can modulate vascular injury and interrupt elevation of pulmonary vascular resistance selectively; however, it can also produce cytotoxic oxygen radicals and exert cytotoxic and antiplatelet effects. The balance between the protective and adverse effects of nitric oxide is determined by the relative amount of nitric oxide and reactive radicals. Nitric oxide has been shown to be clinically effective in the treatment of congenital heart disease, mitrial valvular disease combined with pulmonary hypertension and in orthotropic cardiac transplantation patients. Additionally, new therapeutic modalities for the treatment of pulmonary hypertension, phosphodiesterase inhibitors, natriuretic peptides and aqueous nitric oxide are also effective for treatment of elevated pulmonary vascular resistance.http://ekja.org/upload/pdf/kjae-58-4.pdfnitric oxidepulmonary hypertensionpulmonary vascular resistance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ji-Yeon Sim |
spellingShingle |
Ji-Yeon Sim Nitric oxide and pulmonary hypertension Korean Journal of Anesthesiology nitric oxide pulmonary hypertension pulmonary vascular resistance |
author_facet |
Ji-Yeon Sim |
author_sort |
Ji-Yeon Sim |
title |
Nitric oxide and pulmonary hypertension |
title_short |
Nitric oxide and pulmonary hypertension |
title_full |
Nitric oxide and pulmonary hypertension |
title_fullStr |
Nitric oxide and pulmonary hypertension |
title_full_unstemmed |
Nitric oxide and pulmonary hypertension |
title_sort |
nitric oxide and pulmonary hypertension |
publisher |
Korean Society of Anesthesiologists |
series |
Korean Journal of Anesthesiology |
issn |
2005-6419 2005-7563 |
publishDate |
2010-01-01 |
description |
Pulmonary hypertension is a serious complication of a number of lung and heart diseases that is characterized by peripheral vascular structural remodeling and loss of vascular tone. Nitric oxide can modulate vascular injury and interrupt elevation of pulmonary vascular resistance selectively; however, it can also produce cytotoxic oxygen radicals and exert cytotoxic and antiplatelet effects. The balance between the protective and adverse effects of nitric oxide is determined by the relative amount of nitric oxide and reactive radicals. Nitric oxide has been shown to be clinically effective in the treatment of congenital heart disease, mitrial valvular disease combined with pulmonary hypertension and in orthotropic cardiac transplantation patients. Additionally, new therapeutic modalities for the treatment of pulmonary hypertension, phosphodiesterase inhibitors, natriuretic peptides and aqueous nitric oxide are also effective for treatment of elevated pulmonary vascular resistance. |
topic |
nitric oxide pulmonary hypertension pulmonary vascular resistance |
url |
http://ekja.org/upload/pdf/kjae-58-4.pdf |
work_keys_str_mv |
AT jiyeonsim nitricoxideandpulmonaryhypertension |
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