Asymmetric three-component olefin dicarbofunctionalization enabled by photoredox and copper dual catalysis

Asymmetric three-component olefin dicarbofunctionalization enabled by photoredox and copper dual catalysis

Vicinal dicarbofunctionalization (DCF) reactions of alkenes have been extensively explored in ionic chemistry but the enantioselective radical mediated version of DCF remains largely unexplored. Here, the authors demonstrate a radical vicinal DCF reaction of olefins by merging of radical addition an...

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Main Authors: Peng-Zi Wang, Yuan Gao, Jun Chen, Xiao-Die Huan, Wen-Jing Xiao, Jia-Rong Chen
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22127-x
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spelling doaj-8e07c08667cc47789a6b55f4efbb38082021-03-28T11:12:39ZengNature Publishing GroupNature Communications2041-17232021-03-0112111010.1038/s41467-021-22127-xAsymmetric three-component olefin dicarbofunctionalization enabled by photoredox and copper dual catalysisPeng-Zi Wang0Yuan Gao1Jun Chen2Xiao-Die Huan3Wen-Jing Xiao4Jia-Rong Chen5CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticides & Chemical Biology Ministry of Education, College of Chemistry, Central China Normal UniversityCCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticides & Chemical Biology Ministry of Education, College of Chemistry, Central China Normal UniversityCCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticides & Chemical Biology Ministry of Education, College of Chemistry, Central China Normal UniversityCCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticides & Chemical Biology Ministry of Education, College of Chemistry, Central China Normal UniversityCCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticides & Chemical Biology Ministry of Education, College of Chemistry, Central China Normal UniversityCCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticides & Chemical Biology Ministry of Education, College of Chemistry, Central China Normal UniversityVicinal dicarbofunctionalization (DCF) reactions of alkenes have been extensively explored in ionic chemistry but the enantioselective radical mediated version of DCF remains largely unexplored. Here, the authors demonstrate a radical vicinal DCF reaction of olefins by merging of radical addition and cross-coupling using photoredox and copper dual catalysis.https://doi.org/10.1038/s41467-021-22127-x
collection DOAJ
language English
format Article
sources DOAJ
author Peng-Zi Wang
Yuan Gao
Jun Chen
Xiao-Die Huan
Wen-Jing Xiao
Jia-Rong Chen
spellingShingle Peng-Zi Wang
Yuan Gao
Jun Chen
Xiao-Die Huan
Wen-Jing Xiao
Jia-Rong Chen
Asymmetric three-component olefin dicarbofunctionalization enabled by photoredox and copper dual catalysis
Nature Communications
author_facet Peng-Zi Wang
Yuan Gao
Jun Chen
Xiao-Die Huan
Wen-Jing Xiao
Jia-Rong Chen
author_sort Peng-Zi Wang
title Asymmetric three-component olefin dicarbofunctionalization enabled by photoredox and copper dual catalysis
title_short Asymmetric three-component olefin dicarbofunctionalization enabled by photoredox and copper dual catalysis
title_full Asymmetric three-component olefin dicarbofunctionalization enabled by photoredox and copper dual catalysis
title_fullStr Asymmetric three-component olefin dicarbofunctionalization enabled by photoredox and copper dual catalysis
title_full_unstemmed Asymmetric three-component olefin dicarbofunctionalization enabled by photoredox and copper dual catalysis
title_sort asymmetric three-component olefin dicarbofunctionalization enabled by photoredox and copper dual catalysis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-03-01
description Vicinal dicarbofunctionalization (DCF) reactions of alkenes have been extensively explored in ionic chemistry but the enantioselective radical mediated version of DCF remains largely unexplored. Here, the authors demonstrate a radical vicinal DCF reaction of olefins by merging of radical addition and cross-coupling using photoredox and copper dual catalysis.
url https://doi.org/10.1038/s41467-021-22127-x
work_keys_str_mv AT pengziwang asymmetricthreecomponentolefindicarbofunctionalizationenabledbyphotoredoxandcopperdualcatalysis
AT yuangao asymmetricthreecomponentolefindicarbofunctionalizationenabledbyphotoredoxandcopperdualcatalysis
AT junchen asymmetricthreecomponentolefindicarbofunctionalizationenabledbyphotoredoxandcopperdualcatalysis
AT xiaodiehuan asymmetricthreecomponentolefindicarbofunctionalizationenabledbyphotoredoxandcopperdualcatalysis
AT wenjingxiao asymmetricthreecomponentolefindicarbofunctionalizationenabledbyphotoredoxandcopperdualcatalysis
AT jiarongchen asymmetricthreecomponentolefindicarbofunctionalizationenabledbyphotoredoxandcopperdualcatalysis
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