The Relationship between Betatrophin Levels in Blood and T2DM: A Systematic Review and Meta-Analysis
Background. In order to clarify previous ambiguous research conclusions, a meta-analysis was made to investigate the relationship between betatrophin levels in blood and type 2 diabetes mellitus (T2DM). Methods. We have searched all the English and Chinese references regarding the relationship betwe...
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2016-01-01
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doaj-8e1179f669e5464087cb9a1613156e8a2020-11-24T22:11:20ZengHindawi LimitedDisease Markers0278-02401875-86302016-01-01201610.1155/2016/93918379391837The Relationship between Betatrophin Levels in Blood and T2DM: A Systematic Review and Meta-AnalysisSong Yue0Jingyang Wu1Jiahua Zhang2Lei Liu3Lei Chen4Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang 110001, ChinaBackground. In order to clarify previous ambiguous research conclusions, a meta-analysis was made to investigate the relationship between betatrophin levels in blood and type 2 diabetes mellitus (T2DM). Methods. We have searched all the English and Chinese references regarding the relationship between betatrophin and diabetes in database both manually and online. Strict criteria have been established to include and exclude articles, with Mean and Standard Deviation as statistics to evaluate strength of association. We have chosen either fixed- or random effect model according to heterogeneity inspection results and used Begg’s test and Egger’s test to analyze publication bias. Results. A total of 11 studies were included in this meta-analysis. Meta-analysis indicated a significant association between betatrophin and T2DM (Mean: 329.46; 95% confidence interval: 182.51 to 476.42, P<0.0001). However, in the subgroup analysis, there was no significant statistic between betatrophin concentration and T2DM within Caucasian population (Mean: 98.40; 95% confidence interval: −1585.08 to 1781.88, P=0.91). Conclusions. Such relationship may suggest preference for association between betatrophin and T2DM in different population.http://dx.doi.org/10.1155/2016/9391837 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Song Yue Jingyang Wu Jiahua Zhang Lei Liu Lei Chen |
spellingShingle |
Song Yue Jingyang Wu Jiahua Zhang Lei Liu Lei Chen The Relationship between Betatrophin Levels in Blood and T2DM: A Systematic Review and Meta-Analysis Disease Markers |
author_facet |
Song Yue Jingyang Wu Jiahua Zhang Lei Liu Lei Chen |
author_sort |
Song Yue |
title |
The Relationship between Betatrophin Levels in Blood and T2DM: A Systematic Review and Meta-Analysis |
title_short |
The Relationship between Betatrophin Levels in Blood and T2DM: A Systematic Review and Meta-Analysis |
title_full |
The Relationship between Betatrophin Levels in Blood and T2DM: A Systematic Review and Meta-Analysis |
title_fullStr |
The Relationship between Betatrophin Levels in Blood and T2DM: A Systematic Review and Meta-Analysis |
title_full_unstemmed |
The Relationship between Betatrophin Levels in Blood and T2DM: A Systematic Review and Meta-Analysis |
title_sort |
relationship between betatrophin levels in blood and t2dm: a systematic review and meta-analysis |
publisher |
Hindawi Limited |
series |
Disease Markers |
issn |
0278-0240 1875-8630 |
publishDate |
2016-01-01 |
description |
Background. In order to clarify previous ambiguous research conclusions, a meta-analysis was made to investigate the relationship between betatrophin levels in blood and type 2 diabetes mellitus (T2DM). Methods. We have searched all the English and Chinese references regarding the relationship between betatrophin and diabetes in database both manually and online. Strict criteria have been established to include and exclude articles, with Mean and Standard Deviation as statistics to evaluate strength of association. We have chosen either fixed- or random effect model according to heterogeneity inspection results and used Begg’s test and Egger’s test to analyze publication bias. Results. A total of 11 studies were included in this meta-analysis. Meta-analysis indicated a significant association between betatrophin and T2DM (Mean: 329.46; 95% confidence interval: 182.51 to 476.42, P<0.0001). However, in the subgroup analysis, there was no significant statistic between betatrophin concentration and T2DM within Caucasian population (Mean: 98.40; 95% confidence interval: −1585.08 to 1781.88, P=0.91). Conclusions. Such relationship may suggest preference for association between betatrophin and T2DM in different population. |
url |
http://dx.doi.org/10.1155/2016/9391837 |
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