Repurposing Proteostasis-Modifying Drugs to Prevent or Treat Age-Related Dementia: A Systematic Review

Repurposing Proteostasis-Modifying Drugs to Prevent or Treat Age-Related Dementia: A Systematic Review

Background: Dementia has a significant impact on quality of life of older individuals. Impaired proteostasis has been implicated as a potential cause of dementia, that can be therapeutically targeted to improve patient outcomes. This review aimed to collate all current evidence of the potential for...

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Bibliographic Details
Main Authors: Daniel S. Heard, Camilla S. L. Tuttle, Nicola T. Lautenschlager, Andrea B. Maier
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Physiology
Subjects:
aging
alzheimer's disease
dementia
lithium
proteostasis
rapamycin
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01520/full

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