Evaluation of hemostatic changes using thromboelastography after crystalloid or colloid fluid administration during major orthopedic surgery
The effects of Ringer lactate, 6% hydroxyethyl starch (HES) (130/0.4) or 4% succinylated gelatin solutions on perioperative coagulability were measured by thromboelastography (TEG). Seventy-five patients (ASA I-III) who were to undergo major orthopedic procedures performed under epidural anesthesia...
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Associação Brasileira de Divulgação Científica
2012-09-01
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doaj-8e1902cf6eed48d6b3f7ca81598e33df2020-11-25T00:01:40ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2012-09-01459869874S0100-879X2012000900012Evaluation of hemostatic changes using thromboelastography after crystalloid or colloid fluid administration during major orthopedic surgeryI. Topçu0M. Çivi1T. Öztürk2G.T. Keleş3S. Çoban4E.A. Yentür5G. Okçu6Celal Bayar UniversityCelal Bayar UniversityCelal Bayar UniversityCelal Bayar UniversityCelal Bayar UniversityCelal Bayar UniversityCelal Bayar UniversityThe effects of Ringer lactate, 6% hydroxyethyl starch (HES) (130/0.4) or 4% succinylated gelatin solutions on perioperative coagulability were measured by thromboelastography (TEG). Seventy-five patients (ASA I-III) who were to undergo major orthopedic procedures performed under epidural anesthesia were included in the study. Patients were randomly divided into three groups of 25 each for the administration of maintenance fluids: group RL (Ringer lactate), group HES (6% HES 130/0.4), and group JEL (4% gelofusine solution). Blood samples were obtained during the perioperative period before epidural anesthesia (t1, baseline), at the end of the surgery (t2), and 24 h after the operation (t3). TEG data, reaction time (R), coagulation time (K), angle value (α), and maximum amplitude (MA) were recorded. TEG parameters changed from normal values in all patients. In group RL, R and K times decreased compared to perioperative values while the α angle and MA increased (P < 0.05). In group HES, R and K times increased, however, the α angle and MA decreased (P < 0.05). In group JEL, R time increased (P < 0.05), but K time, α angle and MA did not change significantly. In the present study, RL, 6% HES (130/0.4) and 4% JEL solutions caused changes in the coagulation system of all patients as measured by TEG, but these changes remained within normal limits.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000900012&lng=en&tlng=enHydroxyethyl starchRinger lactateGelatinCoagulationThromboelastographyOrthopedic surgery |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
I. Topçu M. Çivi T. Öztürk G.T. Keleş S. Çoban E.A. Yentür G. Okçu |
spellingShingle |
I. Topçu M. Çivi T. Öztürk G.T. Keleş S. Çoban E.A. Yentür G. Okçu Evaluation of hemostatic changes using thromboelastography after crystalloid or colloid fluid administration during major orthopedic surgery Brazilian Journal of Medical and Biological Research Hydroxyethyl starch Ringer lactate Gelatin Coagulation Thromboelastography Orthopedic surgery |
author_facet |
I. Topçu M. Çivi T. Öztürk G.T. Keleş S. Çoban E.A. Yentür G. Okçu |
author_sort |
I. Topçu |
title |
Evaluation of hemostatic changes using thromboelastography after crystalloid or colloid fluid administration during major orthopedic surgery |
title_short |
Evaluation of hemostatic changes using thromboelastography after crystalloid or colloid fluid administration during major orthopedic surgery |
title_full |
Evaluation of hemostatic changes using thromboelastography after crystalloid or colloid fluid administration during major orthopedic surgery |
title_fullStr |
Evaluation of hemostatic changes using thromboelastography after crystalloid or colloid fluid administration during major orthopedic surgery |
title_full_unstemmed |
Evaluation of hemostatic changes using thromboelastography after crystalloid or colloid fluid administration during major orthopedic surgery |
title_sort |
evaluation of hemostatic changes using thromboelastography after crystalloid or colloid fluid administration during major orthopedic surgery |
publisher |
Associação Brasileira de Divulgação Científica |
series |
Brazilian Journal of Medical and Biological Research |
issn |
1414-431X |
publishDate |
2012-09-01 |
description |
The effects of Ringer lactate, 6% hydroxyethyl starch (HES) (130/0.4) or 4% succinylated gelatin solutions on perioperative coagulability were measured by thromboelastography (TEG). Seventy-five patients (ASA I-III) who were to undergo major orthopedic procedures performed under epidural anesthesia were included in the study. Patients were randomly divided into three groups of 25 each for the administration of maintenance fluids: group RL (Ringer lactate), group HES (6% HES 130/0.4), and group JEL (4% gelofusine solution). Blood samples were obtained during the perioperative period before epidural anesthesia (t1, baseline), at the end of the surgery (t2), and 24 h after the operation (t3). TEG data, reaction time (R), coagulation time (K), angle value (α), and maximum amplitude (MA) were recorded. TEG parameters changed from normal values in all patients. In group RL, R and K times decreased compared to perioperative values while the α angle and MA increased (P < 0.05). In group HES, R and K times increased, however, the α angle and MA decreased (P < 0.05). In group JEL, R time increased (P < 0.05), but K time, α angle and MA did not change significantly. In the present study, RL, 6% HES (130/0.4) and 4% JEL solutions caused changes in the coagulation system of all patients as measured by TEG, but these changes remained within normal limits. |
topic |
Hydroxyethyl starch Ringer lactate Gelatin Coagulation Thromboelastography Orthopedic surgery |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000900012&lng=en&tlng=en |
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