The Neutrophil-to-Monocyte Ratio and Lymphocyte-to-Neutrophil Ratio at Admission Predict In-Hospital Mortality in Mexican Patients with Severe SARS-CoV-2 Infection (Covid-19)
There is a deep need for mortality predictors that allow clinicians to quickly triage patients with severe coronavirus disease 2019 (Covid-19) into intensive care units at the time of hospital admission. Thus, we examined the efficacy of the lymphocyte-to-neutrophil ratio (LNR) and neutrophil-to-mon...
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doaj-8e26c3bd5de742308414ecf7ad7c22c12020-11-25T03:35:31ZengMDPI AGMicroorganisms2076-26072020-10-0181560156010.3390/microorganisms8101560The Neutrophil-to-Monocyte Ratio and Lymphocyte-to-Neutrophil Ratio at Admission Predict In-Hospital Mortality in Mexican Patients with Severe SARS-CoV-2 Infection (Covid-19)Salma A. Rizo-Téllez0Lucia A. Méndez-García1Cruz Flores-Rebollo2Fernando Alba-Flores3Raúl Alcántara-Suárez4Aarón N. Manjarrez-Reyna5Neyla Baltazar-López6Verónica A. Hernández-Guzmán7José I. León-Pedroza8Rogelio Zapata-Arenas9Antonio González-Chávez10Joselín Hernández-Ruíz11José D. Carrillo-Ruíz12Raúl Serrano-Loyola13Guadalupe M. L. Guerrero-Avendaño14Galileo Escobedo15Laboratory of Immunometabolism, Research Division, General Hospital of Mexico “Dr. Eduardo Liceaga”, Mexico City 06720, MexicoLaboratory of Immunometabolism, Research Division, General Hospital of Mexico “Dr. Eduardo Liceaga”, Mexico City 06720, MexicoLaboratory of Immunometabolism, Research Division, General Hospital of Mexico “Dr. Eduardo Liceaga”, Mexico City 06720, MexicoLaboratory of Immunometabolism, Research Division, General Hospital of Mexico “Dr. Eduardo Liceaga”, Mexico City 06720, MexicoLaboratory of Immunometabolism, Research Division, General Hospital of Mexico “Dr. Eduardo Liceaga”, Mexico City 06720, MexicoLaboratory of Immunometabolism, Research Division, General Hospital of Mexico “Dr. Eduardo Liceaga”, Mexico City 06720, MexicoResearch Coordination at Central Laboratories, General Hospital of Mexico “Dr. Eduardo Liceaga”, Mexico City 06720, MexicoResearch Coordination at Central Laboratories, General Hospital of Mexico “Dr. Eduardo Liceaga”, Mexico City 06720, MexicoDepartment of Intensive Medical Therapy, General Hospital of Mexico “Dr. Eduardo Liceaga”, Mexico City 06720, MexicoDepartment of Internal Medicine, General Hospital of Mexico “Dr. Eduardo Liceaga”, Mexico City 06720, MexicoDepartment of Internal Medicine, General Hospital of Mexico “Dr. Eduardo Liceaga”, Mexico City 06720, MexicoClinical Pharmacology Unit, General Hospital of Mexico “Dr. Eduardo Liceaga”, Mexico City 06720, MexicoDepartment of Neurology and Neurosurgery, General Hospital of Mexico “Dr. Eduardo Liceaga”, Mexico City 06720, MexicoDepartment of Radiology and Imaging, General Hospital of Mexico “Dr. Eduardo Liceaga”, Mexico City 06720, MexicoDepartment of Radiology and Imaging, General Hospital of Mexico “Dr. Eduardo Liceaga”, Mexico City 06720, MexicoLaboratory of Immunometabolism, Research Division, General Hospital of Mexico “Dr. Eduardo Liceaga”, Mexico City 06720, MexicoThere is a deep need for mortality predictors that allow clinicians to quickly triage patients with severe coronavirus disease 2019 (Covid-19) into intensive care units at the time of hospital admission. Thus, we examined the efficacy of the lymphocyte-to-neutrophil ratio (LNR) and neutrophil-to-monocyte ratio (NMR) as predictors of in-hospital death at admission in patients with severe Covid-19. A total of 54 Mexican adult patients with Covid-19 that met hospitalization criteria were retrospectively enrolled, followed-up daily until hospital discharge or death, and then assigned to survival or non-survival groups. Clinical, demographic, and laboratory parameters were recorded at admission. A total of 20 patients with severe Covid-19 died, and 75% of them were men older than 62.90 ± 14.18 years on average. Type 2 diabetes, hypertension, and coronary heart disease were more prevalent in non-survivors. As compared to survivors, LNR was significantly fourfold decreased while NMR was twofold increased. LNR ≤ 0.088 predicted in-hospital mortality with a sensitivity of 85.00% and a specificity of 74.19%. NMR ≥ 17.75 was a better independent risk factor for mortality with a sensitivity of 89.47% and a specificity of 80.00%. This study demonstrates for the first time that NMR and LNR are accurate predictors of in-hospital mortality at admission in patients with severe Covid-19.https://www.mdpi.com/2076-2607/8/10/1560SARS-Cov-2Covid-19mortality predictorin-hospital death risklymphocytemonocyte |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Salma A. Rizo-Téllez Lucia A. Méndez-García Cruz Flores-Rebollo Fernando Alba-Flores Raúl Alcántara-Suárez Aarón N. Manjarrez-Reyna Neyla Baltazar-López Verónica A. Hernández-Guzmán José I. León-Pedroza Rogelio Zapata-Arenas Antonio González-Chávez Joselín Hernández-Ruíz José D. Carrillo-Ruíz Raúl Serrano-Loyola Guadalupe M. L. Guerrero-Avendaño Galileo Escobedo |
spellingShingle |
Salma A. Rizo-Téllez Lucia A. Méndez-García Cruz Flores-Rebollo Fernando Alba-Flores Raúl Alcántara-Suárez Aarón N. Manjarrez-Reyna Neyla Baltazar-López Verónica A. Hernández-Guzmán José I. León-Pedroza Rogelio Zapata-Arenas Antonio González-Chávez Joselín Hernández-Ruíz José D. Carrillo-Ruíz Raúl Serrano-Loyola Guadalupe M. L. Guerrero-Avendaño Galileo Escobedo The Neutrophil-to-Monocyte Ratio and Lymphocyte-to-Neutrophil Ratio at Admission Predict In-Hospital Mortality in Mexican Patients with Severe SARS-CoV-2 Infection (Covid-19) Microorganisms SARS-Cov-2 Covid-19 mortality predictor in-hospital death risk lymphocyte monocyte |
author_facet |
Salma A. Rizo-Téllez Lucia A. Méndez-García Cruz Flores-Rebollo Fernando Alba-Flores Raúl Alcántara-Suárez Aarón N. Manjarrez-Reyna Neyla Baltazar-López Verónica A. Hernández-Guzmán José I. León-Pedroza Rogelio Zapata-Arenas Antonio González-Chávez Joselín Hernández-Ruíz José D. Carrillo-Ruíz Raúl Serrano-Loyola Guadalupe M. L. Guerrero-Avendaño Galileo Escobedo |
author_sort |
Salma A. Rizo-Téllez |
title |
The Neutrophil-to-Monocyte Ratio and Lymphocyte-to-Neutrophil Ratio at Admission Predict In-Hospital Mortality in Mexican Patients with Severe SARS-CoV-2 Infection (Covid-19) |
title_short |
The Neutrophil-to-Monocyte Ratio and Lymphocyte-to-Neutrophil Ratio at Admission Predict In-Hospital Mortality in Mexican Patients with Severe SARS-CoV-2 Infection (Covid-19) |
title_full |
The Neutrophil-to-Monocyte Ratio and Lymphocyte-to-Neutrophil Ratio at Admission Predict In-Hospital Mortality in Mexican Patients with Severe SARS-CoV-2 Infection (Covid-19) |
title_fullStr |
The Neutrophil-to-Monocyte Ratio and Lymphocyte-to-Neutrophil Ratio at Admission Predict In-Hospital Mortality in Mexican Patients with Severe SARS-CoV-2 Infection (Covid-19) |
title_full_unstemmed |
The Neutrophil-to-Monocyte Ratio and Lymphocyte-to-Neutrophil Ratio at Admission Predict In-Hospital Mortality in Mexican Patients with Severe SARS-CoV-2 Infection (Covid-19) |
title_sort |
neutrophil-to-monocyte ratio and lymphocyte-to-neutrophil ratio at admission predict in-hospital mortality in mexican patients with severe sars-cov-2 infection (covid-19) |
publisher |
MDPI AG |
series |
Microorganisms |
issn |
2076-2607 |
publishDate |
2020-10-01 |
description |
There is a deep need for mortality predictors that allow clinicians to quickly triage patients with severe coronavirus disease 2019 (Covid-19) into intensive care units at the time of hospital admission. Thus, we examined the efficacy of the lymphocyte-to-neutrophil ratio (LNR) and neutrophil-to-monocyte ratio (NMR) as predictors of in-hospital death at admission in patients with severe Covid-19. A total of 54 Mexican adult patients with Covid-19 that met hospitalization criteria were retrospectively enrolled, followed-up daily until hospital discharge or death, and then assigned to survival or non-survival groups. Clinical, demographic, and laboratory parameters were recorded at admission. A total of 20 patients with severe Covid-19 died, and 75% of them were men older than 62.90 ± 14.18 years on average. Type 2 diabetes, hypertension, and coronary heart disease were more prevalent in non-survivors. As compared to survivors, LNR was significantly fourfold decreased while NMR was twofold increased. LNR ≤ 0.088 predicted in-hospital mortality with a sensitivity of 85.00% and a specificity of 74.19%. NMR ≥ 17.75 was a better independent risk factor for mortality with a sensitivity of 89.47% and a specificity of 80.00%. This study demonstrates for the first time that NMR and LNR are accurate predictors of in-hospital mortality at admission in patients with severe Covid-19. |
topic |
SARS-Cov-2 Covid-19 mortality predictor in-hospital death risk lymphocyte monocyte |
url |
https://www.mdpi.com/2076-2607/8/10/1560 |
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