Lack of Nigral Pathology in Transgenic Mice Expressing Human α-Synuclein Driven by the Tyrosine Hydroxylase Promoter

Lack of Nigral Pathology in Transgenic Mice Expressing Human α-Synuclein Driven by the Tyrosine Hydroxylase Promoter

α-Synuclein has been identified as a major component of Lewy body inclusions, which are one of the pathologic hallmarks of idiopathic Parkinson's disease. Mutations in α-synuclein have been found to be responsible for rare familial cases of Parkinsonism. To test whether overexpression of human...

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Main Authors: Yasuji Matsuoka, Miquel Vila, Sarah Lincoln, Alison McCormack, Melanie Picciano, John LaFrancois, Xin Yu, Dennis Dickson, William J. Langston, Eileen McGowan, Matt Farrer, John Hardy, Karen Duff, Serge Przedborski, Donato A. Di Monte
Format: Article
Language:English
Published: Elsevier 2001-06-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996101903924

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