Cardiac resynchronization therapy in ischemic and non-ischemic cardiomyopathy
Cardiac resynchronization therapy (CRT) using a biventricular pacing system has been an effective therapeutic strategy in patients with symptomatic heart failure with a reduced left ventricular ejection fraction (LVEF) of 35% or less and a QRS duration of 130 ms or more. The etiology of heart failur...
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doaj-8e28e762ed7f499ab1fc8ddc20680fb72020-11-24T23:14:19ZengWileyJournal of Arrhythmia1880-42762017-10-0133541041610.1016/j.joa.2017.03.002Cardiac resynchronization therapy in ischemic and non-ischemic cardiomyopathyHisashi Yokoshiki, MD, PhD0Hirofumi Mitsuyama, MD, PhD1Masaya Watanabe, MD, PhD2Takeshi Mitsuhashi, MD, PhD3Akihiko Shimizu, MD, PhD4Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, JapanDepartment of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, JapanDepartment of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, JapanCardiovascular Medicine, Jichi Medical University Saitama Medical Center, JapanFaculty of Health Sciences, Yamaguchi Graduate School of Medicine, JapanCardiac resynchronization therapy (CRT) using a biventricular pacing system has been an effective therapeutic strategy in patients with symptomatic heart failure with a reduced left ventricular ejection fraction (LVEF) of 35% or less and a QRS duration of 130 ms or more. The etiology of heart failure can be classified as either ischemic or non-ischemic cardiomyopathy. Ischemic etiology of patients receiving CRT is prevalent predominantly in North America, moderately in Europe, and less so in Japan. CRT reduces mortality similarly in both ischemic and non-ischemic cardiomyopathy, whereas reverse structural left ventricular remodeling occurs more favorably in non-ischemic cardiomyopathy. Because the substrate for ventricular arrhythmias appears to be more severe in cases of ischemic as compared with non-ischemic cardiomyopathy, the use of an implantable cardioverter-defibrillator (ICD) backup method could prolong the long-term survival, especially of patients with ischemic cardiomyopathy, even in the presence of CRT. The aim of this review article is to summarize the effects of CRT on outcomes and the role of ICD backup in ischemic and non-ischemic cardiomyopathy.http://www.sciencedirect.com/science/article/pii/S1880427617300467Cardiac resynchronization therapyCRTIschemic cardiomyopathyNon-ischemic cardiomyopathyReverse remodelingImplantable cardioverter-defibrillatorICD |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hisashi Yokoshiki, MD, PhD Hirofumi Mitsuyama, MD, PhD Masaya Watanabe, MD, PhD Takeshi Mitsuhashi, MD, PhD Akihiko Shimizu, MD, PhD |
spellingShingle |
Hisashi Yokoshiki, MD, PhD Hirofumi Mitsuyama, MD, PhD Masaya Watanabe, MD, PhD Takeshi Mitsuhashi, MD, PhD Akihiko Shimizu, MD, PhD Cardiac resynchronization therapy in ischemic and non-ischemic cardiomyopathy Journal of Arrhythmia Cardiac resynchronization therapy CRT Ischemic cardiomyopathy Non-ischemic cardiomyopathy Reverse remodeling Implantable cardioverter-defibrillator ICD |
author_facet |
Hisashi Yokoshiki, MD, PhD Hirofumi Mitsuyama, MD, PhD Masaya Watanabe, MD, PhD Takeshi Mitsuhashi, MD, PhD Akihiko Shimizu, MD, PhD |
author_sort |
Hisashi Yokoshiki, MD, PhD |
title |
Cardiac resynchronization therapy in ischemic and non-ischemic cardiomyopathy |
title_short |
Cardiac resynchronization therapy in ischemic and non-ischemic cardiomyopathy |
title_full |
Cardiac resynchronization therapy in ischemic and non-ischemic cardiomyopathy |
title_fullStr |
Cardiac resynchronization therapy in ischemic and non-ischemic cardiomyopathy |
title_full_unstemmed |
Cardiac resynchronization therapy in ischemic and non-ischemic cardiomyopathy |
title_sort |
cardiac resynchronization therapy in ischemic and non-ischemic cardiomyopathy |
publisher |
Wiley |
series |
Journal of Arrhythmia |
issn |
1880-4276 |
publishDate |
2017-10-01 |
description |
Cardiac resynchronization therapy (CRT) using a biventricular pacing system has been an effective therapeutic strategy in patients with symptomatic heart failure with a reduced left ventricular ejection fraction (LVEF) of 35% or less and a QRS duration of 130 ms or more. The etiology of heart failure can be classified as either ischemic or non-ischemic cardiomyopathy. Ischemic etiology of patients receiving CRT is prevalent predominantly in North America, moderately in Europe, and less so in Japan. CRT reduces mortality similarly in both ischemic and non-ischemic cardiomyopathy, whereas reverse structural left ventricular remodeling occurs more favorably in non-ischemic cardiomyopathy. Because the substrate for ventricular arrhythmias appears to be more severe in cases of ischemic as compared with non-ischemic cardiomyopathy, the use of an implantable cardioverter-defibrillator (ICD) backup method could prolong the long-term survival, especially of patients with ischemic cardiomyopathy, even in the presence of CRT. The aim of this review article is to summarize the effects of CRT on outcomes and the role of ICD backup in ischemic and non-ischemic cardiomyopathy. |
topic |
Cardiac resynchronization therapy CRT Ischemic cardiomyopathy Non-ischemic cardiomyopathy Reverse remodeling Implantable cardioverter-defibrillator ICD |
url |
http://www.sciencedirect.com/science/article/pii/S1880427617300467 |
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