Risk for subsequent infection and mortality after hospitalization among patients with multidrug-resistant gram-negative bacteria colonization or infection
Abstract Background Risks for subsequent multidrug-resistant gram-negative bacteria (MDRGNB) infection and long-term outcome after hospitalization among patients with MDRGNB colonization remain unknown. Methods This observational study enrolled 817 patients who were hospitalized in the study hospita...
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doaj-8e2c214eeab8402daafad69e3db218782020-11-24T21:56:53ZengBMCAntimicrobial Resistance and Infection Control2047-29942018-07-017111210.1186/s13756-018-0388-zRisk for subsequent infection and mortality after hospitalization among patients with multidrug-resistant gram-negative bacteria colonization or infectionWen-Pin Tseng0Yee-Chun Chen1Shang-Yu Chen2Shey-Ying Chen3Shan-Chwen Chang4Department of Emergency Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan UniversityDepartment of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan UniversityDepartment of Emergency Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan UniversityDepartment of Emergency Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan UniversityDepartment of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan UniversityAbstract Background Risks for subsequent multidrug-resistant gram-negative bacteria (MDRGNB) infection and long-term outcome after hospitalization among patients with MDRGNB colonization remain unknown. Methods This observational study enrolled 817 patients who were hospitalized in the study hospital in 2009. We defined MDRGNB as a GNB resistant to at least three different antimicrobial classes. Patients were classified into MDRGNB culture-positive (MDRGNB-CP; 125 patients) and culture-negative (MDRGNB-CN; 692 patients) groups based on the presence or absence of any MDRGNB identified from either active surveillance or clinical cultures during index hospitalization. Subsequent MDRGNB infection and mortality within 12 months after index hospitalization were recorded. We determined the frequency and risk factors for subsequent MDRGNB infection and mortality associated with previous MDRGNB culture status. Results In total, 129 patients had at least one subsequent MDRGNB infection (MDRGNB-CP, 48.0%; MDRGNB-CN, 10.0%), and 148 patients died (MDRGNB-CP, 31.2%; MDRGNB-CN, 15.9%) during the follow-up period. MDR Escherichia coli and Acinetobacter baumannii were the predominant colonization microorganisms; patients with Proteus mirabilis and Pseudomonas aeruginosa had the highest hazard risk for developing subsequent infection. After controlling for other confounders, MDRGNB-CP during hospitalization independently predicted subsequent MDRGNB infection (hazard ratio [HR], 5.35; 95% confidence interval [CI], 3.72–7.71), all-cause mortality (HR, 2.42; 95% CI, 1.67–3.50), and subsequent MDRGNB infection-associated mortality (HR, 4.88; 95% CI, 2.79–8.52) after hospitalization. Conclusions Harboring MDRGNB significantly increases patients’ risk for subsequent MDRGNB infection and mortality after hospitalization, justifying the urgent need for developing effective strategies to prevent and eradicate MDRGNB colonization.http://link.springer.com/article/10.1186/s13756-018-0388-zMultidrug resistanceGram-negative bacteriaColonizationSubsequent infectionMortality |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wen-Pin Tseng Yee-Chun Chen Shang-Yu Chen Shey-Ying Chen Shan-Chwen Chang |
spellingShingle |
Wen-Pin Tseng Yee-Chun Chen Shang-Yu Chen Shey-Ying Chen Shan-Chwen Chang Risk for subsequent infection and mortality after hospitalization among patients with multidrug-resistant gram-negative bacteria colonization or infection Antimicrobial Resistance and Infection Control Multidrug resistance Gram-negative bacteria Colonization Subsequent infection Mortality |
author_facet |
Wen-Pin Tseng Yee-Chun Chen Shang-Yu Chen Shey-Ying Chen Shan-Chwen Chang |
author_sort |
Wen-Pin Tseng |
title |
Risk for subsequent infection and mortality after hospitalization among patients with multidrug-resistant gram-negative bacteria colonization or infection |
title_short |
Risk for subsequent infection and mortality after hospitalization among patients with multidrug-resistant gram-negative bacteria colonization or infection |
title_full |
Risk for subsequent infection and mortality after hospitalization among patients with multidrug-resistant gram-negative bacteria colonization or infection |
title_fullStr |
Risk for subsequent infection and mortality after hospitalization among patients with multidrug-resistant gram-negative bacteria colonization or infection |
title_full_unstemmed |
Risk for subsequent infection and mortality after hospitalization among patients with multidrug-resistant gram-negative bacteria colonization or infection |
title_sort |
risk for subsequent infection and mortality after hospitalization among patients with multidrug-resistant gram-negative bacteria colonization or infection |
publisher |
BMC |
series |
Antimicrobial Resistance and Infection Control |
issn |
2047-2994 |
publishDate |
2018-07-01 |
description |
Abstract Background Risks for subsequent multidrug-resistant gram-negative bacteria (MDRGNB) infection and long-term outcome after hospitalization among patients with MDRGNB colonization remain unknown. Methods This observational study enrolled 817 patients who were hospitalized in the study hospital in 2009. We defined MDRGNB as a GNB resistant to at least three different antimicrobial classes. Patients were classified into MDRGNB culture-positive (MDRGNB-CP; 125 patients) and culture-negative (MDRGNB-CN; 692 patients) groups based on the presence or absence of any MDRGNB identified from either active surveillance or clinical cultures during index hospitalization. Subsequent MDRGNB infection and mortality within 12 months after index hospitalization were recorded. We determined the frequency and risk factors for subsequent MDRGNB infection and mortality associated with previous MDRGNB culture status. Results In total, 129 patients had at least one subsequent MDRGNB infection (MDRGNB-CP, 48.0%; MDRGNB-CN, 10.0%), and 148 patients died (MDRGNB-CP, 31.2%; MDRGNB-CN, 15.9%) during the follow-up period. MDR Escherichia coli and Acinetobacter baumannii were the predominant colonization microorganisms; patients with Proteus mirabilis and Pseudomonas aeruginosa had the highest hazard risk for developing subsequent infection. After controlling for other confounders, MDRGNB-CP during hospitalization independently predicted subsequent MDRGNB infection (hazard ratio [HR], 5.35; 95% confidence interval [CI], 3.72–7.71), all-cause mortality (HR, 2.42; 95% CI, 1.67–3.50), and subsequent MDRGNB infection-associated mortality (HR, 4.88; 95% CI, 2.79–8.52) after hospitalization. Conclusions Harboring MDRGNB significantly increases patients’ risk for subsequent MDRGNB infection and mortality after hospitalization, justifying the urgent need for developing effective strategies to prevent and eradicate MDRGNB colonization. |
topic |
Multidrug resistance Gram-negative bacteria Colonization Subsequent infection Mortality |
url |
http://link.springer.com/article/10.1186/s13756-018-0388-z |
work_keys_str_mv |
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