Sphingolipid Metabolism and Signaling in Skeletal Muscle: From Physiology to Physiopathology
Sphingolipids represent one of the major classes of eukaryotic lipids. They play an essential structural role, especially in cell membranes where they also possess signaling properties and are capable of modulating multiple cell functions, such as apoptosis, cell proliferation, differentiation, and...
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2020-08-01
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doaj-8e4288619d3b4784a173d5af374bf0b22020-11-25T03:03:31ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-08-011110.3389/fendo.2020.00491557432Sphingolipid Metabolism and Signaling in Skeletal Muscle: From Physiology to PhysiopathologySophie Tan-Chen0Sophie Tan-Chen1Jeanne Guitton2Olivier Bourron3Olivier Bourron4Olivier Bourron5Hervé Le Stunff6Eric Hajduch7Eric Hajduch8Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, FranceInstitut Hospitalo-Universitaire ICAN, Paris, FranceUniversité Saclay, CNRS UMR 9197, Institut des Neurosciences Paris-Saclay, Orsay, FranceCentre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, FranceInstitut Hospitalo-Universitaire ICAN, Paris, FranceAssistance Publique-Hôpitaux de Paris, Département de Diabétologie et Maladies Métaboliques, Hôpital Pitié-Salpêtrière, Paris, FranceUniversité Saclay, CNRS UMR 9197, Institut des Neurosciences Paris-Saclay, Orsay, FranceCentre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, FranceInstitut Hospitalo-Universitaire ICAN, Paris, FranceSphingolipids represent one of the major classes of eukaryotic lipids. They play an essential structural role, especially in cell membranes where they also possess signaling properties and are capable of modulating multiple cell functions, such as apoptosis, cell proliferation, differentiation, and inflammation. Many sphingolipid derivatives, such as ceramide, sphingosine-1-phosphate, and ganglioside, have been shown to play many crucial roles in muscle under physiological and pathological conditions. This review will summarize our knowledge of sphingolipids and their effects on muscle fate, highlighting the role of this class of lipids in modulating muscle cell differentiation, regeneration, aging, response to insulin, and contraction. We show that modulating sphingolipid metabolism may be a novel and interesting way for preventing and/or treating several muscle-related diseases.https://www.frontiersin.org/article/10.3389/fendo.2020.00491/fullceramideinsulindiabetesobesitysphingosine-1-phosphateglycosphingolipids |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sophie Tan-Chen Sophie Tan-Chen Jeanne Guitton Olivier Bourron Olivier Bourron Olivier Bourron Hervé Le Stunff Eric Hajduch Eric Hajduch |
spellingShingle |
Sophie Tan-Chen Sophie Tan-Chen Jeanne Guitton Olivier Bourron Olivier Bourron Olivier Bourron Hervé Le Stunff Eric Hajduch Eric Hajduch Sphingolipid Metabolism and Signaling in Skeletal Muscle: From Physiology to Physiopathology Frontiers in Endocrinology ceramide insulin diabetes obesity sphingosine-1-phosphate glycosphingolipids |
author_facet |
Sophie Tan-Chen Sophie Tan-Chen Jeanne Guitton Olivier Bourron Olivier Bourron Olivier Bourron Hervé Le Stunff Eric Hajduch Eric Hajduch |
author_sort |
Sophie Tan-Chen |
title |
Sphingolipid Metabolism and Signaling in Skeletal Muscle: From Physiology to Physiopathology |
title_short |
Sphingolipid Metabolism and Signaling in Skeletal Muscle: From Physiology to Physiopathology |
title_full |
Sphingolipid Metabolism and Signaling in Skeletal Muscle: From Physiology to Physiopathology |
title_fullStr |
Sphingolipid Metabolism and Signaling in Skeletal Muscle: From Physiology to Physiopathology |
title_full_unstemmed |
Sphingolipid Metabolism and Signaling in Skeletal Muscle: From Physiology to Physiopathology |
title_sort |
sphingolipid metabolism and signaling in skeletal muscle: from physiology to physiopathology |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Endocrinology |
issn |
1664-2392 |
publishDate |
2020-08-01 |
description |
Sphingolipids represent one of the major classes of eukaryotic lipids. They play an essential structural role, especially in cell membranes where they also possess signaling properties and are capable of modulating multiple cell functions, such as apoptosis, cell proliferation, differentiation, and inflammation. Many sphingolipid derivatives, such as ceramide, sphingosine-1-phosphate, and ganglioside, have been shown to play many crucial roles in muscle under physiological and pathological conditions. This review will summarize our knowledge of sphingolipids and their effects on muscle fate, highlighting the role of this class of lipids in modulating muscle cell differentiation, regeneration, aging, response to insulin, and contraction. We show that modulating sphingolipid metabolism may be a novel and interesting way for preventing and/or treating several muscle-related diseases. |
topic |
ceramide insulin diabetes obesity sphingosine-1-phosphate glycosphingolipids |
url |
https://www.frontiersin.org/article/10.3389/fendo.2020.00491/full |
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