Methods for analyzing observational longitudinal prognosis studies for rheumatic diseases: a review & worked example using a clinic-based cohort of juvenile dermatomyositis patients
Abstract Most outcome studies of rheumatic diseases report outcomes ascertained on a single occasion. While single assessments are sufficient for terminal or irreversible outcomes, they may not be sufficiently informative if outcomes change or fluctuate over time. Consequently, longitudinal studies...
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doaj-8e474f09e9884aa3804f2f0577817cb42020-11-25T00:16:51ZengBMCPediatric Rheumatology Online Journal1546-00962017-03-011511910.1186/s12969-017-0148-2Methods for analyzing observational longitudinal prognosis studies for rheumatic diseases: a review & worked example using a clinic-based cohort of juvenile dermatomyositis patientsLily Siok Hoon Lim0Eleanor Pullenayegum1Rahim Moineddin2Dafna D Gladman3Earl D Silverman4Brian M Feldman5Children’s Hospital Research Institute of Manitoba, University of ManitobaThe Child Health Evaluative Sciences Program, SickKids Research InstituteDepartment of Family and Community Medicine, University of TorontoDepartment of Medicine, Toronto Western Research Institute, University of TorontoDivision of Rheumatology, SickKidsInstitute of Health Policy Management and Evaluation, University of TorontoAbstract Most outcome studies of rheumatic diseases report outcomes ascertained on a single occasion. While single assessments are sufficient for terminal or irreversible outcomes, they may not be sufficiently informative if outcomes change or fluctuate over time. Consequently, longitudinal studies that measure non-terminal outcomes repeatedly afford a better understanding of disease evolution. Longitudinal studies require special analytic methods. Newer longitudinal analytic methods have evolved tremendously to deal with common challenges in longitudinal observational studies. In recent years, an increasing number of studies have used longitudinal design. This review aims to help readers understand and apply the findings from longitudinal studies. Using a cohort of children with juvenile dermatomyositis (JDM), we illustrate how to study evolution of disease activity in JDM using longitudinal methods.http://link.springer.com/article/10.1186/s12969-017-0148-2EpidemiologyLongitudinal studyChildhood-onset dermatomyositisBiostatistics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lily Siok Hoon Lim Eleanor Pullenayegum Rahim Moineddin Dafna D Gladman Earl D Silverman Brian M Feldman |
spellingShingle |
Lily Siok Hoon Lim Eleanor Pullenayegum Rahim Moineddin Dafna D Gladman Earl D Silverman Brian M Feldman Methods for analyzing observational longitudinal prognosis studies for rheumatic diseases: a review & worked example using a clinic-based cohort of juvenile dermatomyositis patients Pediatric Rheumatology Online Journal Epidemiology Longitudinal study Childhood-onset dermatomyositis Biostatistics |
author_facet |
Lily Siok Hoon Lim Eleanor Pullenayegum Rahim Moineddin Dafna D Gladman Earl D Silverman Brian M Feldman |
author_sort |
Lily Siok Hoon Lim |
title |
Methods for analyzing observational longitudinal prognosis studies for rheumatic diseases: a review & worked example using a clinic-based cohort of juvenile dermatomyositis patients |
title_short |
Methods for analyzing observational longitudinal prognosis studies for rheumatic diseases: a review & worked example using a clinic-based cohort of juvenile dermatomyositis patients |
title_full |
Methods for analyzing observational longitudinal prognosis studies for rheumatic diseases: a review & worked example using a clinic-based cohort of juvenile dermatomyositis patients |
title_fullStr |
Methods for analyzing observational longitudinal prognosis studies for rheumatic diseases: a review & worked example using a clinic-based cohort of juvenile dermatomyositis patients |
title_full_unstemmed |
Methods for analyzing observational longitudinal prognosis studies for rheumatic diseases: a review & worked example using a clinic-based cohort of juvenile dermatomyositis patients |
title_sort |
methods for analyzing observational longitudinal prognosis studies for rheumatic diseases: a review & worked example using a clinic-based cohort of juvenile dermatomyositis patients |
publisher |
BMC |
series |
Pediatric Rheumatology Online Journal |
issn |
1546-0096 |
publishDate |
2017-03-01 |
description |
Abstract Most outcome studies of rheumatic diseases report outcomes ascertained on a single occasion. While single assessments are sufficient for terminal or irreversible outcomes, they may not be sufficiently informative if outcomes change or fluctuate over time. Consequently, longitudinal studies that measure non-terminal outcomes repeatedly afford a better understanding of disease evolution. Longitudinal studies require special analytic methods. Newer longitudinal analytic methods have evolved tremendously to deal with common challenges in longitudinal observational studies. In recent years, an increasing number of studies have used longitudinal design. This review aims to help readers understand and apply the findings from longitudinal studies. Using a cohort of children with juvenile dermatomyositis (JDM), we illustrate how to study evolution of disease activity in JDM using longitudinal methods. |
topic |
Epidemiology Longitudinal study Childhood-onset dermatomyositis Biostatistics |
url |
http://link.springer.com/article/10.1186/s12969-017-0148-2 |
work_keys_str_mv |
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