Divergent Roles for the IL-1 Family in Gastrointestinal Homeostasis and Inflammation
Inflammatory disorders of the gastro-intestinal tract are a major cause of morbidity and significant burden from a health and economic perspective in industrialized countries. While the incidence of such conditions has a strong environmental component, in particular dietary composition, epidemiologi...
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doaj-8e4a47313b184b349356ef5fceb279182020-11-24T21:43:52ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-06-011010.3389/fimmu.2019.01266453720Divergent Roles for the IL-1 Family in Gastrointestinal Homeostasis and InflammationCraig P. McEntee0Craig P. McEntee1Conor M. Finlay2Conor M. Finlay3Ed C. Lavelle4Ed C. Lavelle5Faculty of Biology, Medicine and Health, School of Biological Sciences, Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, United KingdomFaculty of Biology, Medicine and Health, Manchester Collaborative Centre for Inflammation Research, School of Biological Sciences, University of Manchester, Manchester, United KingdomFaculty of Biology, Medicine and Health, School of Biological Sciences, Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, United KingdomFaculty of Biology, Medicine and Health, Wellcome Trust Centre for Cell-Matrix Research, School of Biological Sciences, University of Manchester, Manchester, United KingdomAdjuvant Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, IrelandCentre for Research on Adaptive Nanostructures and Nanodevices (CRANN), Advanced Materials and BioEngineering Research (AMBER), Trinity College Dublin, Dublin, IrelandInflammatory disorders of the gastro-intestinal tract are a major cause of morbidity and significant burden from a health and economic perspective in industrialized countries. While the incidence of such conditions has a strong environmental component, in particular dietary composition, epidemiological studies have identified specific hereditary mutations which result in disequilibrium between pro- and anti-inflammatory factors. The IL-1 super-family of cytokines and receptors is highly pleiotropic and plays a fundamental role in the pathogenesis of several auto-inflammatory conditions including rheumatoid arthritis, multiple sclerosis and psoriasis. However, the role of this super-family in the etiology of inflammatory bowel diseases remains incompletely resolved despite extensive research. Herein, we highlight the currently accepted paradigms as they pertain to specific IL-1 family members and focus on some recently described non-classical roles for these pathways in the gastrointestinal tract. Finally, we address some of the shortcomings and sources of variance in the field which to date have yielded several conflicting results from similar studies and discuss the potential effect of these factors on data interpretation.https://www.frontiersin.org/article/10.3389/fimmu.2019.01266/fullcytokineinflammation immunomodulationgastrointestinalinterleukin-1inflammatory bowel conditions |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Craig P. McEntee Craig P. McEntee Conor M. Finlay Conor M. Finlay Ed C. Lavelle Ed C. Lavelle |
spellingShingle |
Craig P. McEntee Craig P. McEntee Conor M. Finlay Conor M. Finlay Ed C. Lavelle Ed C. Lavelle Divergent Roles for the IL-1 Family in Gastrointestinal Homeostasis and Inflammation Frontiers in Immunology cytokine inflammation immunomodulation gastrointestinal interleukin-1 inflammatory bowel conditions |
author_facet |
Craig P. McEntee Craig P. McEntee Conor M. Finlay Conor M. Finlay Ed C. Lavelle Ed C. Lavelle |
author_sort |
Craig P. McEntee |
title |
Divergent Roles for the IL-1 Family in Gastrointestinal Homeostasis and Inflammation |
title_short |
Divergent Roles for the IL-1 Family in Gastrointestinal Homeostasis and Inflammation |
title_full |
Divergent Roles for the IL-1 Family in Gastrointestinal Homeostasis and Inflammation |
title_fullStr |
Divergent Roles for the IL-1 Family in Gastrointestinal Homeostasis and Inflammation |
title_full_unstemmed |
Divergent Roles for the IL-1 Family in Gastrointestinal Homeostasis and Inflammation |
title_sort |
divergent roles for the il-1 family in gastrointestinal homeostasis and inflammation |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2019-06-01 |
description |
Inflammatory disorders of the gastro-intestinal tract are a major cause of morbidity and significant burden from a health and economic perspective in industrialized countries. While the incidence of such conditions has a strong environmental component, in particular dietary composition, epidemiological studies have identified specific hereditary mutations which result in disequilibrium between pro- and anti-inflammatory factors. The IL-1 super-family of cytokines and receptors is highly pleiotropic and plays a fundamental role in the pathogenesis of several auto-inflammatory conditions including rheumatoid arthritis, multiple sclerosis and psoriasis. However, the role of this super-family in the etiology of inflammatory bowel diseases remains incompletely resolved despite extensive research. Herein, we highlight the currently accepted paradigms as they pertain to specific IL-1 family members and focus on some recently described non-classical roles for these pathways in the gastrointestinal tract. Finally, we address some of the shortcomings and sources of variance in the field which to date have yielded several conflicting results from similar studies and discuss the potential effect of these factors on data interpretation. |
topic |
cytokine inflammation immunomodulation gastrointestinal interleukin-1 inflammatory bowel conditions |
url |
https://www.frontiersin.org/article/10.3389/fimmu.2019.01266/full |
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