An Anatomical Thermal 3D Model in Preclinical Research: Combining CT and Thermal Images
Even though animal trials are a controversial topic, they provide knowledge about diseases and the course of infections in a medical context. To refine the detection of abnormalities that can cause pain and stress to the animal as early as possible, new processes must be developed. Due to its noninv...
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doaj-8e4b4f4a8ed5482e9be01170365ac3bd2021-02-10T00:00:45ZengMDPI AGSensors1424-82202021-02-01211200120010.3390/s21041200An Anatomical Thermal 3D Model in Preclinical Research: Combining CT and Thermal ImagesFranziska Schollemann0Carina Barbosa Pereira1Stefanie Rosenhain2Andreas Follmann3Felix Gremse4Fabian Kiessling5Michael Czaplik6Mauren Abreu de Souza7Department of Anesthesiology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, GermanyDepartment of Anesthesiology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, GermanyInstitute for Experimental Molecular Imaging, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, GermanyDepartment of Anesthesiology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, GermanyInstitute for Experimental Molecular Imaging, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, GermanyInstitute for Experimental Molecular Imaging, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, GermanyDepartment of Anesthesiology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, GermanyPost Graduate Program on Health Technology, Polytechnique School, Pontifical Catholic University of Paraná, R. Imac. Conceição, Curitiba 1155, BrazilEven though animal trials are a controversial topic, they provide knowledge about diseases and the course of infections in a medical context. To refine the detection of abnormalities that can cause pain and stress to the animal as early as possible, new processes must be developed. Due to its noninvasive nature, thermal imaging is increasingly used for severity assessment in animal-based research. Within a multimodal approach, thermal images combined with anatomical information could be used to simulate the inner temperature profile, thereby allowing the detection of deep-seated infections. This paper presents the generation of anatomical thermal 3D models, forming the underlying multimodal model in this simulation. These models combine anatomical 3D information based on computed tomography (CT) data with a registered thermal shell measured with infrared thermography. The process of generating these models consists of data acquisition (both thermal images and CT), camera calibration, image processing methods, and structure from motion (SfM), among others. Anatomical thermal 3D models were successfully generated using three anesthetized mice. Due to the image processing improvement, the process was also realized for areas with few features, which increases the transferability of the process. The result of this multimodal registration in 3D space can be viewed and analyzed within a visualization tool. Individual CT slices can be analyzed axially, sagittally, and coronally with the corresponding superficial skin temperature distribution. This is an important and successfully implemented milestone on the way to simulating the internal temperature profile. Using this temperature profile, deep-seated infections and inflammation can be detected in order to reduce animal suffering.https://www.mdpi.com/1424-8220/21/4/1200thermal imagingCT3D modelVisualSFMcamera calibrationregistration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Franziska Schollemann Carina Barbosa Pereira Stefanie Rosenhain Andreas Follmann Felix Gremse Fabian Kiessling Michael Czaplik Mauren Abreu de Souza |
spellingShingle |
Franziska Schollemann Carina Barbosa Pereira Stefanie Rosenhain Andreas Follmann Felix Gremse Fabian Kiessling Michael Czaplik Mauren Abreu de Souza An Anatomical Thermal 3D Model in Preclinical Research: Combining CT and Thermal Images Sensors thermal imaging CT 3D model VisualSFM camera calibration registration |
author_facet |
Franziska Schollemann Carina Barbosa Pereira Stefanie Rosenhain Andreas Follmann Felix Gremse Fabian Kiessling Michael Czaplik Mauren Abreu de Souza |
author_sort |
Franziska Schollemann |
title |
An Anatomical Thermal 3D Model in Preclinical Research: Combining CT and Thermal Images |
title_short |
An Anatomical Thermal 3D Model in Preclinical Research: Combining CT and Thermal Images |
title_full |
An Anatomical Thermal 3D Model in Preclinical Research: Combining CT and Thermal Images |
title_fullStr |
An Anatomical Thermal 3D Model in Preclinical Research: Combining CT and Thermal Images |
title_full_unstemmed |
An Anatomical Thermal 3D Model in Preclinical Research: Combining CT and Thermal Images |
title_sort |
anatomical thermal 3d model in preclinical research: combining ct and thermal images |
publisher |
MDPI AG |
series |
Sensors |
issn |
1424-8220 |
publishDate |
2021-02-01 |
description |
Even though animal trials are a controversial topic, they provide knowledge about diseases and the course of infections in a medical context. To refine the detection of abnormalities that can cause pain and stress to the animal as early as possible, new processes must be developed. Due to its noninvasive nature, thermal imaging is increasingly used for severity assessment in animal-based research. Within a multimodal approach, thermal images combined with anatomical information could be used to simulate the inner temperature profile, thereby allowing the detection of deep-seated infections. This paper presents the generation of anatomical thermal 3D models, forming the underlying multimodal model in this simulation. These models combine anatomical 3D information based on computed tomography (CT) data with a registered thermal shell measured with infrared thermography. The process of generating these models consists of data acquisition (both thermal images and CT), camera calibration, image processing methods, and structure from motion (SfM), among others. Anatomical thermal 3D models were successfully generated using three anesthetized mice. Due to the image processing improvement, the process was also realized for areas with few features, which increases the transferability of the process. The result of this multimodal registration in 3D space can be viewed and analyzed within a visualization tool. Individual CT slices can be analyzed axially, sagittally, and coronally with the corresponding superficial skin temperature distribution. This is an important and successfully implemented milestone on the way to simulating the internal temperature profile. Using this temperature profile, deep-seated infections and inflammation can be detected in order to reduce animal suffering. |
topic |
thermal imaging CT 3D model VisualSFM camera calibration registration |
url |
https://www.mdpi.com/1424-8220/21/4/1200 |
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