p53 Protein Isoform Profiles in AML: Correlation with Distinct Differentiation Stages and Response to Epigenetic Differentiation Therapy

p53 Protein Isoform Profiles in AML: Correlation with Distinct Differentiation Stages and Response to Epigenetic Differentiation Therapy

p53 protein isoform expression has been found to correlate with prognosis and chemotherapy response in acute myeloid leukemia (AML). We aimed to investigate how p53 protein isoforms are modulated during epigenetic differentiation therapy in AML, and if p53 isoform expression could be a potential bio...

Full description

Bibliographic Details
Main Authors:	Ingvild Haaland, Sigrun M. Hjelle, Håkon Reikvam, André Sulen, Anita Ryningen, Emmet McCormack, Øystein Bruserud, Bjørn Tore Gjertsen
Format:	Article
Language:	English
Published:	MDPI AG 2021-04-01
Series:	Cells
Subjects:	p53 protein isoforms acute myeloid leukemia differentiation therapy French–American–British (FAB) classification valproic acid all-<i>trans</i> retinoic acid
Online Access:	https://www.mdpi.com/2073-4409/10/4/833

Similar Items

Disease-stabilizing treatment based on all-trans retinoic acid and valproic acid in acute myeloid leukemia – identification of responders by gene expression profiling of pretreatment leukemic cells
by: Håkon Reikvam, et al.
Published: (2017-09-01)

Systemic Metabolomic Profiling of Acute Myeloid Leukemia Patients before and During Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid, Valproic Acid, and Low-Dose Chemotherapy
by: Ida Sofie Grønningsæter, et al.
Published: (2019-10-01)

Therapeutic Use of Valproic Acid and All-Trans Retinoic Acid in Acute Myeloid Leukemia—Literature Review and Discussion of Possible Use in Relapse after Allogeneic Stem Cell Transplantation
by: Øystein Bruserud, et al.
Published: (2021-05-01)

Proteomic Studies of Primary Acute Myeloid Leukemia Cells Derived from Patients Before and during Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid and Valproic Acid
by: Maria Hernandez-Valladares, et al.
Published: (2021-04-01)

HDAC inhibitor valproic acid increases CRABP2 expression and in combination with retinoic acid synergistically inhibits proliferation in glioblastoma cells
by: Yao, Lei
Published: (2016)

Retinoic Acids in the Treatment of Most Lethal Solid Cancers
by: Lara Costantini, et al.
Published: (2020-01-01)

A Comparison of p53 Isoform Profiles and Apoptosis Induced by Camptothecin or a Herbal Khat Extract (<i>Catha Edulis (Vahl) Forssk. ex Endl.</i>) in Leukemic Cell Lines: Exploring Cellular Responses in Therapy Development
by: Therese Bredholt Onyango, et al.
Published: (2020-12-01)

The effect of carbamazepine on valproic acid metabolism
by: Panesar, Sukhbinder Kaur
Published: (2010)

Pharmacokinetics of two monounsaturated metabolites of valproic acid in the rat
by: Singh, Kuldeep
Published: (2010)

Enhanced Antiproliferative Effect of Combined Treatment with Calcitriol and All-<i>Trans</i> Retinoic Acid in Relation to Vitamin D Receptor and Retinoic Acid Receptor α Expression in Osteosarcoma Cell Lines
by: Silvia Paukovcekova, et al.
Published: (2020-09-01)

Differentiated all-trans retinoic acid response of naive CD4+CD25– cells isolated from rats with collagen-induced arthritis and healthy ones under in vitro conditions
by: Isaura Felcenloben, et al.
Published: (2017-05-01)

Dehydroepiandroesteron Accompanied Retinoic Acid Enhances Differentiation of P19 Embryonal Stem Cells into Neural Cells
by: Hossein Azizi, et al.
Published: (2009-01-01)

Pharmacokinetic and metabolism studies of valproic acid using gas chromatography mass spectrometry
by: Acheampong, Andrew Adu
Published: (2010)

Short Communication: Oral Administration of Heat-killed <i>Lactobacillus brevis</i> KB290 in Combination with Retinoic Acid Provides Protection against Influenza Virus Infection in Mice
by: Shohei Satomi, et al.
Published: (2020-09-01)

Effect of valproic acid on stem cell development and functional recovery of ischemic mice.
Published: (2012)

Differential Gene Expression Profile Induced by Valproic Acid (VPA) in Pediatric Epileptic Patients
by: Esaú Floriano-Sánchez, et al.
Published: (2018-06-01)

Differentiating Neuroblastoma: A Systematic Review of the Retinoic Acid, Its Derivatives, and Synergistic Interactions
by: Nadiya Bayeva, et al.
Published: (2021-03-01)

Biomodulatory Treatment With Azacitidine, All-trans Retinoic Acid and Pioglitazone Induces Differentiation of Primary AML Blasts Into Neutrophil Like Cells Capable of ROS Production and Phagocytosis
by: Sebastian Klobuch, et al.
Published: (2018-11-01)

The Role of Retinoic Acid in Establishing the Early Limb Bud
by: Eleanor Feneck, et al.
Published: (2020-02-01)

Differential Expression of Multiple Disease-Related Protein Groups Induced by Valproic Acid in Human SH-SY5Y Neuroblastoma Cells
by: Tsung-Ming Hu, et al.
Published: (2020-08-01)

Maturation State-Specific Alternative Splicing in <i>FLT3</i>-ITD and NPM1 Mutated AML
by: Anna Wojtuszkiewicz, et al.
Published: (2021-08-01)

FSH regulates RA signaling to commit spermatogonia into differentiation pathway and meiosis
by: Maryam Khanehzad, et al.
Published: (2021-01-01)

Retinoic acid and glycolic acid combination in the treatment of acne scars
by: B S Chandrashekar, et al.
Published: (2015-01-01)

Pharmacokinetics, tissue distribution, and pharmacodynamics of valproic acid and its unsaturated metabolites in rats
by: Lee, Ronald Duane
Published: (2011)

Negative ion chemical ionization GCMS analysis of valproic acid and its metabolites
by: Kassahun, Kelem
Published: (2010)

Quantitative structure-anticonvulsant activity studies of valproic acid analogues
by: Acheampong, Andrew Adu
Published: (2010)

GCMS analysis of valproic acid metabolites and the effects of salicylate on valproic acid metabolism
by: Kassam, Jeanine Posset
Published: (2010)

Identification of influential proteins in the classical retinoic acid signaling pathway
by: Hamed Ghaffari, et al.
Published: (2018-10-01)

Mitochondrial Liver Toxicity of Valproic Acid and Its Acid Derivatives Is Related to Inhibition of α-Lipoamide Dehydrogenase
by: Alexei P. Kudin, et al.
Published: (2017-09-01)

Wnt and Hedgehog Signaling Regulate the Differentiation of F9 Cells into Extraembryonic Endoderm
by: Gurjoth S. J. Deol, et al.
Published: (2017-10-01)

The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic Differentiation to TRAIL Mediated Apoptosis
by: Eva Szegezdi, et al.
Published: (2011-03-01)

Valproate-induced hyperammonemic encephalopathy: a case report
by: Suhal Shah, et al.
Published: (2020-01-01)

Risk of Serious Skin Rash with Antiepileptic Drugs
by: J Gordon Millichap
Published: (1997-09-01)

Valproic acid-associated pancytopenia: A dose-dependent adverse effect
by: Jamir Pitton Rissardo, et al.
Published: (2019-09-01)

Ammonia Blood Levels and Valproic Acid
by: J Gordon Millichap
Published: (2007-12-01)

Manifestations of Familial Hemiplegic Migraine
by: J Gordon Millichap
Published: (2012-10-01)

Epilepsy and Autism
by: J Gordon Millichap
Published: (1997-04-01)

Valproic Acid and Thrombocytopenia
by: J Gordon Millichap
Published: (1996-08-01)

Prognosis of Cyclic Vomiting Syndrome
by: J. Gordon Millichap
Published: (2016-03-01)

Severe Valproic Acid Intoxication Responding to Hemodialysis
by: Ali Ertuğ Arslanköylü, et al.
Published: (2017-08-01)