Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii

Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii

Chemical investigation of the Mediterranean ascidian Ciona edwardsii has been performed, leading to the isolation of two halogenated compounds: a new tyrosine-iodinated derivative iodocionin (1) and the relevant brominated analogue (2), previously isolated from a Caribbean sponge. The structure of t...

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Bibliographic Details
Main Authors: Werner E.G. Müller, Marialuisa Menna, Concetta Imperatore, Ernesto Fattorusso, Anna Aiello
Format: Article
Language:English
Published: MDPI AG 2010-02-01
Series:Marine Drugs
Subjects:
natural products
iodinated metabolites
cytotoxic activity
structure elucidation
Online Access:http://www.mdpi.com/1660-3397/8/2/285/
Description
Summary:Chemical investigation of the Mediterranean ascidian Ciona edwardsii has been performed, leading to the isolation of two halogenated compounds: a new tyrosine-iodinated derivative iodocionin (1) and the relevant brominated analogue (2), previously isolated from a Caribbean sponge. The structure of the new compound 1 has been assigned on the basis of spectroscopic analysis.Both compounds were tested for cytotoxicity in vitro against two different cancer cell lines, L5178Y (mouse lymphoma) and PC-12 (rat pheochromocytoma). Iodocionin was shown to possess significant and selective activity against lymphoma cells with an IC50 of 7.75 μg/mL.
ISSN:1660-3397

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