Improving detection of tuberculosis among household contacts of index tuberculosis patients by an integrated approach in Myanmar: a cross-sectional study

Abstract Background Contact tracing for tuberculosis (TB) is a recommended measure to improve the case detection rate; however, actual implementation in Myanmar is limited and low detection rates have been reported. Household contacts of a known index TB case are at high risk of infection, thus a mo...

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Main Authors: Kyaw Ko Ko Htet, Tippawan Liabsuetrakul, Saw Thein, Edward B. McNeil, Virasakdi Chongsuvivatwong
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Infectious Diseases
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12879-018-3586-7
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spelling doaj-8e6238b220f94c4bbaba91ed2690edfa2020-11-25T03:40:02ZengBMCBMC Infectious Diseases1471-23342018-12-011811810.1186/s12879-018-3586-7Improving detection of tuberculosis among household contacts of index tuberculosis patients by an integrated approach in Myanmar: a cross-sectional studyKyaw Ko Ko Htet0Tippawan Liabsuetrakul1Saw Thein2Edward B. McNeil3Virasakdi Chongsuvivatwong4Department of Medical Research (Pyin Oo Lwin Branch)Epidemiology Unit, Faculty of Medicine, Prince of Songkla UniversityMinistry of Health and Sports, National Tuberculosis ProgrammeEpidemiology Unit, Faculty of Medicine, Prince of Songkla UniversityEpidemiology Unit, Faculty of Medicine, Prince of Songkla UniversityAbstract Background Contact tracing for tuberculosis (TB) is a recommended measure to improve the case detection rate; however, actual implementation in Myanmar is limited and low detection rates have been reported. Household contacts of a known index TB case are at high risk of infection, thus a more strategic action for contact tracing is required to achieve the goal of the World Health Organization End TB Strategy. This study aimed to assess TB case detection rates among household contacts by an integrated approach and identify risk factors for TB. Methods A cross-sectional study was conducted in Mandalay City, Myanmar. Household contacts of index TB cases who had been receiving treatment for at least 3 months were prospectively investigated by an integrated approach which included modification of screening methods and active facilitation of screening investigations as follows. Initial chest x-ray (CXR) was performed for all contacts at the responsible facilities followed by sputum specimen collection for those aged ≥15 years and gene Xpert MTB/RIF examination. Transportation of all household contacts to health facilities and transportation of sputum samples for smear and gene Xpert MTB/RIF examination at centers were arranged by the research team to ensure that all household contacts received all investigations. Risk factors for TB among household contacts were identified by multiple logistic regression models. Results Of 174 household contacts, 115 were ≥ 15 years and 59 were < 15 years. The percentage of TB cases detected among the household contacts was 13.8%. There were 14 (12.2%) positive TB cases among the 115 contacts aged ≥15 years while 10 (16.9%) of those aged < 15 years had clinical signs and symptoms of TB with an abnormal CXR. Risk factors among household contacts for TB were being a caretaker of an index case, active and passive smoking, and drinking alcohol. Conclusions The integrated approach of TB contact tracing by special arrangement for CXR, sputum and gene Xpert MTB/RIF examination yielded a high TB detection rate in a high TB prevalence area. Logistic and financial administration is needed to strengthen contact tracing. Further research on high-risk household contacts should be considered for increasing TB detection rates.http://link.springer.com/article/10.1186/s12879-018-3586-7TuberculosisScreeningCase detectionDeterminantsContact tracing
collection DOAJ
language English
format Article
sources DOAJ
author Kyaw Ko Ko Htet
Tippawan Liabsuetrakul
Saw Thein
Edward B. McNeil
Virasakdi Chongsuvivatwong
spellingShingle Kyaw Ko Ko Htet
Tippawan Liabsuetrakul
Saw Thein
Edward B. McNeil
Virasakdi Chongsuvivatwong
Improving detection of tuberculosis among household contacts of index tuberculosis patients by an integrated approach in Myanmar: a cross-sectional study
BMC Infectious Diseases
Tuberculosis
Screening
Case detection
Determinants
Contact tracing
author_facet Kyaw Ko Ko Htet
Tippawan Liabsuetrakul
Saw Thein
Edward B. McNeil
Virasakdi Chongsuvivatwong
author_sort Kyaw Ko Ko Htet
title Improving detection of tuberculosis among household contacts of index tuberculosis patients by an integrated approach in Myanmar: a cross-sectional study
title_short Improving detection of tuberculosis among household contacts of index tuberculosis patients by an integrated approach in Myanmar: a cross-sectional study
title_full Improving detection of tuberculosis among household contacts of index tuberculosis patients by an integrated approach in Myanmar: a cross-sectional study
title_fullStr Improving detection of tuberculosis among household contacts of index tuberculosis patients by an integrated approach in Myanmar: a cross-sectional study
title_full_unstemmed Improving detection of tuberculosis among household contacts of index tuberculosis patients by an integrated approach in Myanmar: a cross-sectional study
title_sort improving detection of tuberculosis among household contacts of index tuberculosis patients by an integrated approach in myanmar: a cross-sectional study
publisher BMC
series BMC Infectious Diseases
issn 1471-2334
publishDate 2018-12-01
description Abstract Background Contact tracing for tuberculosis (TB) is a recommended measure to improve the case detection rate; however, actual implementation in Myanmar is limited and low detection rates have been reported. Household contacts of a known index TB case are at high risk of infection, thus a more strategic action for contact tracing is required to achieve the goal of the World Health Organization End TB Strategy. This study aimed to assess TB case detection rates among household contacts by an integrated approach and identify risk factors for TB. Methods A cross-sectional study was conducted in Mandalay City, Myanmar. Household contacts of index TB cases who had been receiving treatment for at least 3 months were prospectively investigated by an integrated approach which included modification of screening methods and active facilitation of screening investigations as follows. Initial chest x-ray (CXR) was performed for all contacts at the responsible facilities followed by sputum specimen collection for those aged ≥15 years and gene Xpert MTB/RIF examination. Transportation of all household contacts to health facilities and transportation of sputum samples for smear and gene Xpert MTB/RIF examination at centers were arranged by the research team to ensure that all household contacts received all investigations. Risk factors for TB among household contacts were identified by multiple logistic regression models. Results Of 174 household contacts, 115 were ≥ 15 years and 59 were < 15 years. The percentage of TB cases detected among the household contacts was 13.8%. There were 14 (12.2%) positive TB cases among the 115 contacts aged ≥15 years while 10 (16.9%) of those aged < 15 years had clinical signs and symptoms of TB with an abnormal CXR. Risk factors among household contacts for TB were being a caretaker of an index case, active and passive smoking, and drinking alcohol. Conclusions The integrated approach of TB contact tracing by special arrangement for CXR, sputum and gene Xpert MTB/RIF examination yielded a high TB detection rate in a high TB prevalence area. Logistic and financial administration is needed to strengthen contact tracing. Further research on high-risk household contacts should be considered for increasing TB detection rates.
topic Tuberculosis
Screening
Case detection
Determinants
Contact tracing
url http://link.springer.com/article/10.1186/s12879-018-3586-7
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