Viral aetiology of central nervous system infections in adults admitted to a tertiary referral hospital in southern Vietnam over 12 years.
Central nervous system (CNS) infections are important diseases in both children and adults worldwide. The spectrum of infections is broad, encompassing bacterial/aseptic meningitis and encephalitis. Viruses are regarded as the most common causes of encephalitis and aseptic meningitis. Better underst...
Main Authors: | , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-08-01
|
Series: | PLoS Neglected Tropical Diseases |
Online Access: | http://europepmc.org/articles/PMC4148224?pdf=render |
id |
doaj-8e68c04631d247cc8b97c57584cbff0b |
---|---|
record_format |
Article |
spelling |
doaj-8e68c04631d247cc8b97c57584cbff0b2020-11-25T02:08:06ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352014-08-0188e312710.1371/journal.pntd.0003127Viral aetiology of central nervous system infections in adults admitted to a tertiary referral hospital in southern Vietnam over 12 years.Le Van TanLe Hong ThaiNguyen Hoan PhuHo Dang Trung NghiaLy Van ChuongDinh Xuan SinhNguyen Duy PhongNguyen Thi Hoang MaiDinh Nguyen Huy ManVo Minh HienNguyen Thanh VinhJeremy DayNguyen Van Vinh ChauTran Tinh HienJeremy FarrarMenno D de JongGuy ThwaitesH Rogier van DoornTran Thi Hong ChauCentral nervous system (CNS) infections are important diseases in both children and adults worldwide. The spectrum of infections is broad, encompassing bacterial/aseptic meningitis and encephalitis. Viruses are regarded as the most common causes of encephalitis and aseptic meningitis. Better understanding of the viral causes of the diseases is of public health importance, in order to better inform immunization policy, and may influence clinical management.Study was conducted at the Hospital for Tropical Diseases in Ho Chi Minh City, a primary, secondary, and tertiary referral hospital for all southern provinces of Vietnam. Between December 1996 and May 2008, patients with CNS infections of presumed viral origin were enrolled. Laboratory diagnostics consisted of molecular and serological tests targeted at 14 meningitis/encephalitis-associated viruses. Of 291 enrolled patients, fatal outcome and neurological sequelae were recorded in 10% (28/291) and 27% (78/291), respectively. Mortality was especially high (9/19, 47%) amongst those with confirmed herpes simplex encephalitis which is attributed to the limited availability of intravenous acyclovir/valacyclovir. Japanese encephalitis virus, dengue virus, herpes simplex virus, and enteroviruses were the most common viruses detected, responsible for 36 (12%), 19 (6.5%), 19 (6.5%) and 8 (2.7%) respectively, followed by rubella virus (6, 2%), varicella zoster virus (5, 1.7%), mumps virus (2, 0.7%), cytomegalovirus (1, 0.3%), and rabies virus (1, 0.3%).Viral infections of the CNS in adults in Vietnam are associated with high morbidity and mortality. Despite extensive laboratory testing, 68% of the patients remain undiagnosed. Together with our previous reports, the data confirm that Japanese encephalitis virus, dengue virus, herpes simplex virus, and enteroviruses are the leading identified causes of CNS viral infections in Vietnam, suggest that the majority of morbidity/mortality amongst patients with a confirmed/probable diagnosis is preventable by adequate vaccination/treatment, and are therefore of public health significance.http://europepmc.org/articles/PMC4148224?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Le Van Tan Le Hong Thai Nguyen Hoan Phu Ho Dang Trung Nghia Ly Van Chuong Dinh Xuan Sinh Nguyen Duy Phong Nguyen Thi Hoang Mai Dinh Nguyen Huy Man Vo Minh Hien Nguyen Thanh Vinh Jeremy Day Nguyen Van Vinh Chau Tran Tinh Hien Jeremy Farrar Menno D de Jong Guy Thwaites H Rogier van Doorn Tran Thi Hong Chau |
spellingShingle |
Le Van Tan Le Hong Thai Nguyen Hoan Phu Ho Dang Trung Nghia Ly Van Chuong Dinh Xuan Sinh Nguyen Duy Phong Nguyen Thi Hoang Mai Dinh Nguyen Huy Man Vo Minh Hien Nguyen Thanh Vinh Jeremy Day Nguyen Van Vinh Chau Tran Tinh Hien Jeremy Farrar Menno D de Jong Guy Thwaites H Rogier van Doorn Tran Thi Hong Chau Viral aetiology of central nervous system infections in adults admitted to a tertiary referral hospital in southern Vietnam over 12 years. PLoS Neglected Tropical Diseases |
author_facet |
Le Van Tan Le Hong Thai Nguyen Hoan Phu Ho Dang Trung Nghia Ly Van Chuong Dinh Xuan Sinh Nguyen Duy Phong Nguyen Thi Hoang Mai Dinh Nguyen Huy Man Vo Minh Hien Nguyen Thanh Vinh Jeremy Day Nguyen Van Vinh Chau Tran Tinh Hien Jeremy Farrar Menno D de Jong Guy Thwaites H Rogier van Doorn Tran Thi Hong Chau |
author_sort |
Le Van Tan |
title |
Viral aetiology of central nervous system infections in adults admitted to a tertiary referral hospital in southern Vietnam over 12 years. |
title_short |
Viral aetiology of central nervous system infections in adults admitted to a tertiary referral hospital in southern Vietnam over 12 years. |
title_full |
Viral aetiology of central nervous system infections in adults admitted to a tertiary referral hospital in southern Vietnam over 12 years. |
title_fullStr |
Viral aetiology of central nervous system infections in adults admitted to a tertiary referral hospital in southern Vietnam over 12 years. |
title_full_unstemmed |
Viral aetiology of central nervous system infections in adults admitted to a tertiary referral hospital in southern Vietnam over 12 years. |
title_sort |
viral aetiology of central nervous system infections in adults admitted to a tertiary referral hospital in southern vietnam over 12 years. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Neglected Tropical Diseases |
issn |
1935-2727 1935-2735 |
publishDate |
2014-08-01 |
description |
Central nervous system (CNS) infections are important diseases in both children and adults worldwide. The spectrum of infections is broad, encompassing bacterial/aseptic meningitis and encephalitis. Viruses are regarded as the most common causes of encephalitis and aseptic meningitis. Better understanding of the viral causes of the diseases is of public health importance, in order to better inform immunization policy, and may influence clinical management.Study was conducted at the Hospital for Tropical Diseases in Ho Chi Minh City, a primary, secondary, and tertiary referral hospital for all southern provinces of Vietnam. Between December 1996 and May 2008, patients with CNS infections of presumed viral origin were enrolled. Laboratory diagnostics consisted of molecular and serological tests targeted at 14 meningitis/encephalitis-associated viruses. Of 291 enrolled patients, fatal outcome and neurological sequelae were recorded in 10% (28/291) and 27% (78/291), respectively. Mortality was especially high (9/19, 47%) amongst those with confirmed herpes simplex encephalitis which is attributed to the limited availability of intravenous acyclovir/valacyclovir. Japanese encephalitis virus, dengue virus, herpes simplex virus, and enteroviruses were the most common viruses detected, responsible for 36 (12%), 19 (6.5%), 19 (6.5%) and 8 (2.7%) respectively, followed by rubella virus (6, 2%), varicella zoster virus (5, 1.7%), mumps virus (2, 0.7%), cytomegalovirus (1, 0.3%), and rabies virus (1, 0.3%).Viral infections of the CNS in adults in Vietnam are associated with high morbidity and mortality. Despite extensive laboratory testing, 68% of the patients remain undiagnosed. Together with our previous reports, the data confirm that Japanese encephalitis virus, dengue virus, herpes simplex virus, and enteroviruses are the leading identified causes of CNS viral infections in Vietnam, suggest that the majority of morbidity/mortality amongst patients with a confirmed/probable diagnosis is preventable by adequate vaccination/treatment, and are therefore of public health significance. |
url |
http://europepmc.org/articles/PMC4148224?pdf=render |
work_keys_str_mv |
AT levantan viralaetiologyofcentralnervoussysteminfectionsinadultsadmittedtoatertiaryreferralhospitalinsouthernvietnamover12years AT lehongthai viralaetiologyofcentralnervoussysteminfectionsinadultsadmittedtoatertiaryreferralhospitalinsouthernvietnamover12years AT nguyenhoanphu viralaetiologyofcentralnervoussysteminfectionsinadultsadmittedtoatertiaryreferralhospitalinsouthernvietnamover12years AT hodangtrungnghia viralaetiologyofcentralnervoussysteminfectionsinadultsadmittedtoatertiaryreferralhospitalinsouthernvietnamover12years AT lyvanchuong viralaetiologyofcentralnervoussysteminfectionsinadultsadmittedtoatertiaryreferralhospitalinsouthernvietnamover12years AT dinhxuansinh viralaetiologyofcentralnervoussysteminfectionsinadultsadmittedtoatertiaryreferralhospitalinsouthernvietnamover12years AT nguyenduyphong viralaetiologyofcentralnervoussysteminfectionsinadultsadmittedtoatertiaryreferralhospitalinsouthernvietnamover12years AT nguyenthihoangmai viralaetiologyofcentralnervoussysteminfectionsinadultsadmittedtoatertiaryreferralhospitalinsouthernvietnamover12years AT dinhnguyenhuyman viralaetiologyofcentralnervoussysteminfectionsinadultsadmittedtoatertiaryreferralhospitalinsouthernvietnamover12years AT vominhhien viralaetiologyofcentralnervoussysteminfectionsinadultsadmittedtoatertiaryreferralhospitalinsouthernvietnamover12years AT nguyenthanhvinh viralaetiologyofcentralnervoussysteminfectionsinadultsadmittedtoatertiaryreferralhospitalinsouthernvietnamover12years AT jeremyday viralaetiologyofcentralnervoussysteminfectionsinadultsadmittedtoatertiaryreferralhospitalinsouthernvietnamover12years AT nguyenvanvinhchau viralaetiologyofcentralnervoussysteminfectionsinadultsadmittedtoatertiaryreferralhospitalinsouthernvietnamover12years AT trantinhhien viralaetiologyofcentralnervoussysteminfectionsinadultsadmittedtoatertiaryreferralhospitalinsouthernvietnamover12years AT jeremyfarrar viralaetiologyofcentralnervoussysteminfectionsinadultsadmittedtoatertiaryreferralhospitalinsouthernvietnamover12years AT mennoddejong viralaetiologyofcentralnervoussysteminfectionsinadultsadmittedtoatertiaryreferralhospitalinsouthernvietnamover12years AT guythwaites viralaetiologyofcentralnervoussysteminfectionsinadultsadmittedtoatertiaryreferralhospitalinsouthernvietnamover12years AT hrogiervandoorn viralaetiologyofcentralnervoussysteminfectionsinadultsadmittedtoatertiaryreferralhospitalinsouthernvietnamover12years AT tranthihongchau viralaetiologyofcentralnervoussysteminfectionsinadultsadmittedtoatertiaryreferralhospitalinsouthernvietnamover12years |
_version_ |
1724927529594126336 |