BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors

BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors

Bone morphogenetic protein (BMP) signaling exerts paradoxical roles in pluripotent stem cells (PSCs); it sustains self-renewal of mouse embryonic stem cells (ESCs), while it induces differentiation in other PSCs, including human ESCs. Here, we revisit the roles of BMP-4 using mouse ESCs (mESCs) in n...

Full description

Bibliographic Details
Main Authors: Masato Morikawa, Daizo Koinuma, Anna Mizutani, Natsumi Kawasaki, Katarina Holmborn, Anders Sundqvist, Shuichi Tsutsumi, Tetsuro Watabe, Hiroyuki Aburatani, Carl-Henrik Heldin, Kohei Miyazono
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671115003690

Similar Items

Similar Items