Apolipoprotein E ε4 and ε3 alleles associate with cerebrospinal fluid tau and cognition in the presence of amyloid-𝜷 in mild cognitive impairment but not in Alzheimer’s disease
Apolipoprotein E is the most well-established genetic risk factor for Alzheimer’s disease. However, the associations of apolipoprotein E with tau pathology and cognition remain controversial. The research checks the hypothesis that the relationships between apolipoprotein E alleles and cerebrospi...
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doaj-8e7cf2ad20c8465687f8570d928d541a2021-07-14T08:59:00ZengIMR (Innovative Medical Research) Press LimitedJournal of Integrative Neuroscience1757-448X2021-06-0120227728610.31083/j.jin20020271625014726838-1248727081Apolipoprotein E ε4 and ε3 alleles associate with cerebrospinal fluid tau and cognition in the presence of amyloid-𝜷 in mild cognitive impairment but not in Alzheimer’s diseaseFeng Xing0Tao Meng1Joseph Therriault2Jing Luo3Hua Zhang4Alzheimer’s Disease Neuroimaging InitiativeDepartment of Neurology, the First Affiliated Hospital of Chongqing Medical University, 400016 Chongqing, ChinaDepartment of Neurology, Chongqing University Central Hospital, 400014 Chongqing, ChinaThe McGill University Research Centre for Studies in Aging, McGill University, Montreal, QC H3A 0G4, CanadaDepartment of Neurology, the First Affiliated Hospital of Chongqing Medical University, 400016 Chongqing, ChinaDepartment of Neurology, the First Affiliated Hospital of Chongqing Medical University, 400016 Chongqing, ChinaApolipoprotein E is the most well-established genetic risk factor for Alzheimer’s disease. However, the associations of apolipoprotein E with tau pathology and cognition remain controversial. The research checks the hypothesis that the relationships between apolipoprotein E alleles and cerebrospinal fluid tau and cognition differ in persons with and without significant amyloid-β deposition. We divided 1119 subjects into cognitively normal (n = 275), mild cognitive impairment (n = 629), and Alzheimer’s disease (n = 215), and these subjects were from the Alzheimer’s Disease Neuroimaging Initiative database. Linear regression models were used to compare the relationships of apolipoprotein E alleles with cerebrospinal fluid tau and cognition in persons with significant amyloid-β deposition relative to individuals without significant amyloid-β deposition. The associations of apolipoprotein E ε4 and ε3 with total tau (T-tau), phosphorylated tau (P-tau), and Alzheimer’s disease assessment scale was significantly substantial among participants with significant amyloid-β deposition. Stratified analyses showed that apolipoprotein E ε4 related to increased concentrations of T-tau, P-tau, and Alzheimer’s disease assessment scale and apolipoprotein E ε3 associated with decreased concentrations of T-tau, P-tau, and Alzheimer’s disease assessment scale in mild cognitive impairment participants with significant amyloid-β deposition, but not in Alzheimer’s disease. Our study shows that the presence of apolipoprotein E ε4 and ε3 alleles is related to tau pathology and cognitive impairment in the presence of amyloid-β in mild cognitive impairment, but not in Alzheimer’s disease. This work indirectly provides additional evidence that apolipoprotein E and amyloid-β may not have a role in modulating clinical Alzheimer’s disease, and apolipoprotein E ε3 may be supposed to be protective to mild cognitive impairment.https://jin.imrpress.com/fileup/1757-448X/PDF/1625014726838-1248727081.pdfalzheimer's diseaseamyloid-βapolipoprotein emild cognitive impairmenttau |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Feng Xing Tao Meng Joseph Therriault Jing Luo Hua Zhang Alzheimer’s Disease Neuroimaging Initiative |
spellingShingle |
Feng Xing Tao Meng Joseph Therriault Jing Luo Hua Zhang Alzheimer’s Disease Neuroimaging Initiative Apolipoprotein E ε4 and ε3 alleles associate with cerebrospinal fluid tau and cognition in the presence of amyloid-𝜷 in mild cognitive impairment but not in Alzheimer’s disease Journal of Integrative Neuroscience alzheimer's disease amyloid-β apolipoprotein e mild cognitive impairment tau |
author_facet |
Feng Xing Tao Meng Joseph Therriault Jing Luo Hua Zhang Alzheimer’s Disease Neuroimaging Initiative |
author_sort |
Feng Xing |
title |
Apolipoprotein E ε4 and ε3 alleles associate with cerebrospinal fluid tau and cognition in the presence of amyloid-𝜷 in mild cognitive impairment but not in Alzheimer’s disease |
title_short |
Apolipoprotein E ε4 and ε3 alleles associate with cerebrospinal fluid tau and cognition in the presence of amyloid-𝜷 in mild cognitive impairment but not in Alzheimer’s disease |
title_full |
Apolipoprotein E ε4 and ε3 alleles associate with cerebrospinal fluid tau and cognition in the presence of amyloid-𝜷 in mild cognitive impairment but not in Alzheimer’s disease |
title_fullStr |
Apolipoprotein E ε4 and ε3 alleles associate with cerebrospinal fluid tau and cognition in the presence of amyloid-𝜷 in mild cognitive impairment but not in Alzheimer’s disease |
title_full_unstemmed |
Apolipoprotein E ε4 and ε3 alleles associate with cerebrospinal fluid tau and cognition in the presence of amyloid-𝜷 in mild cognitive impairment but not in Alzheimer’s disease |
title_sort |
apolipoprotein e ε4 and ε3 alleles associate with cerebrospinal fluid tau and cognition in the presence of amyloid-𝜷 in mild cognitive impairment but not in alzheimer’s disease |
publisher |
IMR (Innovative Medical Research) Press Limited |
series |
Journal of Integrative Neuroscience |
issn |
1757-448X |
publishDate |
2021-06-01 |
description |
Apolipoprotein E is the most well-established genetic risk
factor for Alzheimer’s disease. However, the associations of apolipoprotein E
with tau pathology and cognition remain controversial. The research checks the hypothesis that the relationships between apolipoprotein E alleles and
cerebrospinal fluid tau and cognition differ in persons with and without
significant amyloid-β deposition. We divided 1119 subjects into
cognitively normal (n = 275), mild cognitive impairment (n = 629), and
Alzheimer’s disease (n = 215), and these subjects were from the Alzheimer’s Disease Neuroimaging
Initiative database. Linear regression models were used to compare the
relationships of apolipoprotein E alleles with cerebrospinal fluid tau and cognition in persons with
significant amyloid-β deposition relative to individuals without significant
amyloid-β deposition. The associations of apolipoprotein E ε4 and
ε3 with total tau (T-tau), phosphorylated tau (P-tau), and Alzheimer’s
disease assessment scale was significantly substantial among participants
with significant amyloid-β deposition. Stratified analyses showed that
apolipoprotein E ε4 related to increased concentrations of T-tau, P-tau,
and Alzheimer’s disease assessment scale and apolipoprotein E ε3 associated with decreased
concentrations of T-tau, P-tau, and Alzheimer’s disease assessment scale in mild cognitive impairment participants with significant
amyloid-β deposition, but not in Alzheimer’s disease. Our study shows that the presence of
apolipoprotein E ε4 and ε3 alleles is related to tau pathology
and cognitive impairment in the presence of amyloid-β in mild cognitive impairment, but not in Alzheimer’s disease.
This work indirectly provides additional evidence that apolipoprotein E and
amyloid-β may not have a role in modulating clinical Alzheimer’s disease, and apolipoprotein E ε3 may be supposed to be protective to mild cognitive impairment. |
topic |
alzheimer's disease amyloid-β apolipoprotein e mild cognitive impairment tau |
url |
https://jin.imrpress.com/fileup/1757-448X/PDF/1625014726838-1248727081.pdf |
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