Enhanced susceptibility to spontaneous seizures of noda epileptic rats by loss of synaptic zn(2+).
Zinc homeostasis in the brain is associated with the etiology and manifestation of epileptic seizures. Adult Noda epileptic rats (NER, >12-week-old) exhibit spontaneously generalized tonic-clonic convulsion about once a day. To pursue the involvement of synaptic Zn(2+) signal in susceptibility to...
Main Authors: | Atsushi Takeda, Masashi Iida, Masaki Ando, Masatoshi Nakamura, Haruna Tamano, Naoto Oku |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3741169?pdf=render |
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