Tamoxifen Derivatives Alter Retromer-Dependent Endosomal Tubulation and Sorting to Block Retrograde Trafficking of Shiga Toxins
Shiga toxin 1 and 2 (STx1 and STx2) undergo retrograde trafficking to reach the cytosol of cells where they target ribosomes. As retrograde trafficking is essential for disease, inhibiting STx1/STx2 trafficking is therapeutically promising. Recently, we discovered that the chemotherapeutic drug tamo...
Main Authors: | Andrey S. Selyunin, Karinel Nieves-Merced, Danyang Li, Stanton F. McHardy, Somshuvra Mukhopadhyay |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-06-01
|
Series: | Toxins |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6651/13/6/424 |
Similar Items
-
Characterization of Cellular Pathways and Potency of Shiga Toxin on Endothelial Cells
by: MacMaster, Kayleigh A.
Published: (2015) -
Characterization of Shiga Toxin Potency and Assembly
by: Pellino, Christine A.
Published: (2014) -
Editorial: Recent Advances in Understanding the Pathogenesis of Shiga Toxin-Producing Shigella and Escherichia coli
by: Moo-Seung Lee, et al.
Published: (2020-11-01) -
Roles of Shiga Toxins in Immunopathology
by: Moo-Seung Lee, et al.
Published: (2019-04-01) -
Isolation and characterization of Shiga toxigenic Escherichia coli of animal and bird origin by multiplex polymerase chain reaction
by: S. Neher, et al.
Published: (2016-02-01)