The Acinetobacter baumannii disinfectant resistance protein, AmvA, is a spermidine and spermine efflux pump

The Acinetobacter baumannii disinfectant resistance protein, AmvA, is a spermidine and spermine efflux pump

Francesca Short et al. identify natural polyamines as substrates for a drug efflux pump in the clinically-relevant pathogen, Acinetobacter baumannii. Their results suggest that efflux pumps now known to be involved in drug resistance may have originated as polyamine transporters.

Bibliographic Details
Main Authors: Francesca L. Short, Qi Liu, Bhumika Shah, Heather E. Clift, Varsha Naidu, Liping Li, Farzana T. Prity, Bridget C. Mabbutt, Karl A. Hassan, Ian T. Paulsen
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02629-6
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spelling doaj-8e858361117f461b89e8f68cd27b22732021-09-26T11:14:30ZengNature Publishing GroupCommunications Biology2399-36422021-09-014111210.1038/s42003-021-02629-6The Acinetobacter baumannii disinfectant resistance protein, AmvA, is a spermidine and spermine efflux pumpFrancesca L. Short0Qi Liu1Bhumika Shah2Heather E. Clift3Varsha Naidu4Liping Li5Farzana T. Prity6Bridget C. Mabbutt7Karl A. Hassan8Ian T. Paulsen9Department of Molecular Sciences, Macquarie UniversityDepartment of Molecular Sciences, Macquarie UniversityDepartment of Molecular Sciences, Macquarie UniversityDepartment of Molecular Sciences, Macquarie UniversityDepartment of Molecular Sciences, Macquarie UniversityDepartment of Molecular Sciences, Macquarie UniversityDepartment of Molecular Sciences, Macquarie UniversityDepartment of Molecular Sciences, Macquarie UniversitySchool of Environmental and Life Sciences, University of NewcastleDepartment of Molecular Sciences, Macquarie UniversityFrancesca Short et al. identify natural polyamines as substrates for a drug efflux pump in the clinically-relevant pathogen, Acinetobacter baumannii. Their results suggest that efflux pumps now known to be involved in drug resistance may have originated as polyamine transporters.https://doi.org/10.1038/s42003-021-02629-6
collection DOAJ
language English
format Article
sources DOAJ
author Francesca L. Short
Qi Liu
Bhumika Shah
Heather E. Clift
Varsha Naidu
Liping Li
Farzana T. Prity
Bridget C. Mabbutt
Karl A. Hassan
Ian T. Paulsen
spellingShingle Francesca L. Short
Qi Liu
Bhumika Shah
Heather E. Clift
Varsha Naidu
Liping Li
Farzana T. Prity
Bridget C. Mabbutt
Karl A. Hassan
Ian T. Paulsen
The Acinetobacter baumannii disinfectant resistance protein, AmvA, is a spermidine and spermine efflux pump
Communications Biology
author_facet Francesca L. Short
Qi Liu
Bhumika Shah
Heather E. Clift
Varsha Naidu
Liping Li
Farzana T. Prity
Bridget C. Mabbutt
Karl A. Hassan
Ian T. Paulsen
author_sort Francesca L. Short
title The Acinetobacter baumannii disinfectant resistance protein, AmvA, is a spermidine and spermine efflux pump
title_short The Acinetobacter baumannii disinfectant resistance protein, AmvA, is a spermidine and spermine efflux pump
title_full The Acinetobacter baumannii disinfectant resistance protein, AmvA, is a spermidine and spermine efflux pump
title_fullStr The Acinetobacter baumannii disinfectant resistance protein, AmvA, is a spermidine and spermine efflux pump
title_full_unstemmed The Acinetobacter baumannii disinfectant resistance protein, AmvA, is a spermidine and spermine efflux pump
title_sort acinetobacter baumannii disinfectant resistance protein, amva, is a spermidine and spermine efflux pump
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-09-01
description Francesca Short et al. identify natural polyamines as substrates for a drug efflux pump in the clinically-relevant pathogen, Acinetobacter baumannii. Their results suggest that efflux pumps now known to be involved in drug resistance may have originated as polyamine transporters.
url https://doi.org/10.1038/s42003-021-02629-6
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