Citrus flavonoid improves MK-801-induced locomotive hyperactivity: Possible relevance to schizophrenia

Citrus flavonoid improves MK-801-induced locomotive hyperactivity: Possible relevance to schizophrenia

Enhanced dopaminergic activity in rodents has been shown to lead to locomotor hyperactivity. MK-801, an NMDA (N-methyl-d-aspartate) receptor antagonist, indirectly activates dopaminergic activity in humans and rodents, and has the ability to induce locomotor hyperactivity. Abnormalities in locomotor...

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Bibliographic Details
Main Authors: Satoshi Okuyama, Takahiro Fukata, Yuki Nishigawa, Yoshiaki Amakura, Morio Yoshimura, Takashi Yoshida, Mitsunari Nakajima, Yoshiko Furukawa
Format: Article
Language:English
Published: Elsevier 2013-10-01
Series:Journal of Functional Foods
Subjects:
Heptamethoxyflavone
MK-801
Schizophrenia-like behavior
Locomotion
Y-maze test
Open field test
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464613001795

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