Association Between Depression, Anxiety, and Antidepressant Use With T-Wave Amplitude and QT-Interval
Objectives: Cardiac repolarization may be affected by psychiatric disorders and/or antidepressant use, but evidence for this is inconclusive. This study examined the relationship between depressive and anxiety disorder and use of antidepressants with T-wave amplitude (TWA) and QT-interval.Methods: D...
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doaj-8e97276520d441d28c549e165d8a2ecd2020-11-25T00:09:39ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2018-06-011210.3389/fnins.2018.00375378820Association Between Depression, Anxiety, and Antidepressant Use With T-Wave Amplitude and QT-IntervalMandy X. Hu0Femke Lamers1Brenda W. J. H. Penninx2Eco J. C. de Geus3Department of Psychiatry, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, NetherlandsDepartment of Psychiatry, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, NetherlandsDepartment of Psychiatry, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, NetherlandsDepartment of Biological Psychology, VU University, Amsterdam, NetherlandsObjectives: Cardiac repolarization may be affected by psychiatric disorders and/or antidepressant use, but evidence for this is inconclusive. This study examined the relationship between depressive and anxiety disorder and use of antidepressants with T-wave amplitude (TWA) and QT-interval.Methods: Data was obtained from the Netherlands Study of Depression and Anxiety (n = 1,383). Depression/anxiety was diagnosed with the DSM-IV based Composite International Diagnostic Interview. The use of tricyclic antidepressants (TCAs), selective serotonin and noradrenalin reuptake inhibitors (SNRIs), and selective serotonin reuptake inhibitors (SSRIs) was established. T-wave amplitude and QT-interval corrected for heart rate (QTc) were obtained from an ECG measured in a type II axis configuration.Results: Compared to controls, persons with depression or anxiety disorders did not show a significantly different TWA (p = 0.58; Cohen's d = 0.046) or QTc (p = 0.48; Cohen's d = −0.057). In spite of known sympathomimetic effects, TCA use (p = 0.26; Cohen's d = −0.162) and SNRI use (p = 0.70; Cohen's d = −0.055) were not significantly associated with a lower TWA. TCA use (p = 0.12; Cohen's d = 0.225) and SNRI use (p = 0.11; Cohen's d = 0.227) were also not significantly associated with a prolonged QTc.Conclusion: We did not find evidence that either depressive/anxiety disorder or antidepressant use is associated with abnormalities in TWA or QTc. Earlier found sympathomimetic effects of TCAs and SNRIs are not evident in these measures of cardiac repolarization.https://www.frontiersin.org/article/10.3389/fnins.2018.00375/fullautonomic nervous systemcardiac repolarizationdepressionanxietyantidepressant |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mandy X. Hu Femke Lamers Brenda W. J. H. Penninx Eco J. C. de Geus |
spellingShingle |
Mandy X. Hu Femke Lamers Brenda W. J. H. Penninx Eco J. C. de Geus Association Between Depression, Anxiety, and Antidepressant Use With T-Wave Amplitude and QT-Interval Frontiers in Neuroscience autonomic nervous system cardiac repolarization depression anxiety antidepressant |
author_facet |
Mandy X. Hu Femke Lamers Brenda W. J. H. Penninx Eco J. C. de Geus |
author_sort |
Mandy X. Hu |
title |
Association Between Depression, Anxiety, and Antidepressant Use With T-Wave Amplitude and QT-Interval |
title_short |
Association Between Depression, Anxiety, and Antidepressant Use With T-Wave Amplitude and QT-Interval |
title_full |
Association Between Depression, Anxiety, and Antidepressant Use With T-Wave Amplitude and QT-Interval |
title_fullStr |
Association Between Depression, Anxiety, and Antidepressant Use With T-Wave Amplitude and QT-Interval |
title_full_unstemmed |
Association Between Depression, Anxiety, and Antidepressant Use With T-Wave Amplitude and QT-Interval |
title_sort |
association between depression, anxiety, and antidepressant use with t-wave amplitude and qt-interval |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2018-06-01 |
description |
Objectives: Cardiac repolarization may be affected by psychiatric disorders and/or antidepressant use, but evidence for this is inconclusive. This study examined the relationship between depressive and anxiety disorder and use of antidepressants with T-wave amplitude (TWA) and QT-interval.Methods: Data was obtained from the Netherlands Study of Depression and Anxiety (n = 1,383). Depression/anxiety was diagnosed with the DSM-IV based Composite International Diagnostic Interview. The use of tricyclic antidepressants (TCAs), selective serotonin and noradrenalin reuptake inhibitors (SNRIs), and selective serotonin reuptake inhibitors (SSRIs) was established. T-wave amplitude and QT-interval corrected for heart rate (QTc) were obtained from an ECG measured in a type II axis configuration.Results: Compared to controls, persons with depression or anxiety disorders did not show a significantly different TWA (p = 0.58; Cohen's d = 0.046) or QTc (p = 0.48; Cohen's d = −0.057). In spite of known sympathomimetic effects, TCA use (p = 0.26; Cohen's d = −0.162) and SNRI use (p = 0.70; Cohen's d = −0.055) were not significantly associated with a lower TWA. TCA use (p = 0.12; Cohen's d = 0.225) and SNRI use (p = 0.11; Cohen's d = 0.227) were also not significantly associated with a prolonged QTc.Conclusion: We did not find evidence that either depressive/anxiety disorder or antidepressant use is associated with abnormalities in TWA or QTc. Earlier found sympathomimetic effects of TCAs and SNRIs are not evident in these measures of cardiac repolarization. |
topic |
autonomic nervous system cardiac repolarization depression anxiety antidepressant |
url |
https://www.frontiersin.org/article/10.3389/fnins.2018.00375/full |
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