Dynamin-Related Protein 1 Inhibitors Protect against Ischemic Toxicity through Attenuating Mitochondrial Ca2+ Uptake from Endoplasmic Reticulum Store in PC12 Cells

Dynamin-Related Protein 1 Inhibitors Protect against Ischemic Toxicity through Attenuating Mitochondrial Ca2+ Uptake from Endoplasmic Reticulum Store in PC12 Cells

Intracellular calcium homeostasis disorder and mitochondrial dysfunction are involved in many acute and chronic brain diseases, including ischemic brain injury. An imbalance in mitochondrial fission and fusion is one of the most important structural abnormalities found in a large number of mitochon...

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Bibliographic Details
Main Authors: Ye Tian, Bin Li, Wen-Zhen Shi, Ming-Ze Chang, Ge-Juan Zhang, Zheng-Li Di, Yong Liu
Format: Article
Language:English
Published: MDPI AG 2014-02-01
Series:International Journal of Molecular Sciences
Subjects:
stroke
Drp-1
calcium
mitochondria
endoplasmic reticulum
Online Access:http://www.mdpi.com/1422-0067/15/2/3172

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